Protein Alignment Jhedup and AADACL3

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001096640.2
• Gene: AADACL3 / 126767
• HGNCID: 32037
• Length: 407
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 86/427 - (20%)
• Similarity: 134/427 - (31%)
• Gaps: 145/427 - (33%)

  Fly   104 LNVYRPKNRAEDKLPVMVYIHGGGFFSGSA---HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLS 165
            :.:|:||.......|.:||.||||...||.   |.:.|   .|...:..|::.:.||..|
Human    99 VKLYQPKASTCTLKPGIVYYHGGGGVMGSLKTHHGICS---RLCKESDSVVLAVGYRKLP----- 155

  Fly   166 TGDEH---MPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQ 227
               :|   :|    .:|..:|.....|.:..:|.||.:|.|.|.|.||..|
Human   156 ---KHKFPVP----VRDCLVATIHFLKSLDAYGVDPARVVVCGDSFGGAIA-------------- 199

  Fly   228 NSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVD---- 288
                                           |:...:.:...||......:....:|.::|
Human   200 -------------------------------AVVCQQLVDRPDLPRIRAQILIYAILQALDLQTP 233

  Fly   289 SLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFIN 353
            |.:...|:|.||...:.      .|..::                |..||...|   .||:   .
Human   234 SFQQRKNIPLLTWSFIC------YFFFQN----------------LDFSSSWQE---VIMK---G 270

  Fly   354 PKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFK-GDSLNNDTMLKLAEI--------- 408
            ..|.||..|.:.:.:.     ||..|.:....   .|..| .:.:|....|:::.:
Human   271 AHLPAEVWEKYRKWLG-----PENIPERFKER---GYQLKPHEPMNEAAYLEVSVVLDVMCSPLI 327

  Fly   409 -SGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAV--HMDDG 470
             ..|.....|  ||......|..|.:|.|               .:....:|.|:...  ||:||
Human   328 AEDDIVSQLP--ETCIVSCEYDALRDNSL---------------LYKKRLEDLGVPVTWHHMEDG 375

  Fly   471 LHTI--RIPVSFDDFPKDSEDAKVIQRMSSLMTDFAK 505
            .|.:  .|.:||..||       ...|:.|.:..|.|
Human   376 FHGVLRTIDMSFLHFP-------CSMRILSALVQFVK 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	86/427 (20%)
AADACL3	NP_001096640.2	Abhydrolase_3	115..378	CDD:400284	72/375 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/1 (100%)