DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces1g

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	564	Identity:	155/564 - (27%)
Similarity:	250/564 - (44%)	Gaps:	95/564 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SLDVCLEDMG---------CMRGTLMPGYQSGE-----FEAFMGIPFAQPPVGPLRLKNPVPNEP 69
            ||..|| .:|         .:.|.::..|.:.|     ...|:|:|||:||:|.||...|.|.||
Mouse    10 SLTACL-SLGHPSLPPVVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEP 73

  Fly    70 WEGVLDAGAAKDSCIQR--------SYFAKEWGLMG---VEDCLYLNVYRPKNRAED-KLPVMVY 122
            |..|....:....|.|.        ..|..:..::.   .|||||||:|.|.:..:: :|||||:
Mouse    74 WSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVW 138

  Fly   123 IHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWI 187
            |||||.....|......|  |.....||:|.:.||||.:||.||.|||..||:|..||..||.|:
Mouse   139 IHGGGLVIDGASTYDGVP--LAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHWV 201

  Fly   188 QKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPL---S 249
            |.:||.|||:|..||:.|.||||.|..:.::||.:|.||..:::.:..:|        :|.   .
Mouse   202 QDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIF--------NPCLFGR 258

  Fly   250 QARRLGKEL-AIDQAESLSSQDLAEALRNVCPKKLLV--------SVDSL-KVWDNMPHLTTL-- 302
            .||.|.|:: |:...::.:|..:...||.....:||.        :||.| ...::.|.|.|:
Mouse   259 AARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVID 323

  Fly   303 PVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRA-GEGSLFIMRAFINPKLRAEFNENFLE 366
            .||...:|:..|.|.        ..|.:|:::.::... |    :|:..|::..|    :|..|:
Mouse   324 GVLLPKAPEEILAEK--------SFNTVPYMVGINKHEFG----WIIPMFLDFPL----SERKLD 372

  Fly   367 HMALLLNLPEGTPVQMVSEIL---DAYDFKGDSLNNDTMLKL-AEISGDFNFYYPIYETISSYVT 427
            .......|.:..|:..:||.|   ....:.|.:.:..||..| .::.||..|..|     |..|:
Mouse   373 QKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVP-----SVIVS 432

  Fly   428 YANLEEN-PLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKD---SE 488
            .::.:.. |.::|.:::.     ..|.:.......||. |.|:.......|     |.|:   .|
Mouse   433 RSHRDAGAPTYMYEYQYR-----PSFVSDDRPQELLGD-HADELFSVWGAP-----FLKEGASEE 486

  Fly   489 DAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFG 532
            :..:.:.:.....:||:.|..:.|.:....::.::.  .||..|
Mouse   487 EINLSKMVMKFWANFARNGNPNGEGLPHWPEYDQKE--GYLQIG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	145/517 (28%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	49/104 (47%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	150/549 (27%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	55/119 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850