DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Cel

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_034015.1	Gene:	Cel / 12613	MGIID:	88374	Length:	599	Species:	Mus musculus

Alignment Length:	546	Identity:	153/546 - (28%)
Similarity:	242/546 - (44%)	Gaps:	95/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFAGFGVLLFVAVAVGDSLDVCLEDMGCMRG-----TLMPGYQSGEFEAFMGIPFAQPPVGPLR 60
            :||.|....|  |.|....|.....:.|.:.|     :|:.|   ...:.|.|||||....
Mouse     6 VLFLGLTCCL--AAACAAKLGAVYTEGGFVEGVNKKLSLLGG---DSVDIFKGIPFATAKT---- 61

  Fly    61 LKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAE--DKLPVMVYI 123
            |:||..:..|:|.|.|...|..|:|.:  ..:....|.|||||||::.|:.|.:  ..|||||:|
Mouse    62 LENPQRHPGWQGTLKATNFKKRCLQAT--ITQDNTYGQEDCLYLNIWVPQGRKQVSHNLPVMVWI 124

  Fly   124 HGGGFFSGSAHPMASGPEYLMD------TNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRL 182
            :||.|..||.........||.|      ...|::||.|||:||.|||||||.::|||||.:||.:
Mouse   125 YGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHM 189

  Fly   183 ALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDP 247
            |:.|::::||.|||||..:|:.|.|||..|..|..:||.:|||.:.::|.:| |.||...|.|:|
Mouse   190 AIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSG-MALSPWAIQKNP 253

  Fly   248 LSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKV----WDNMPHLTTLPVLEAP 308
            |..|:.:.|::.....:   :..:|..|:...|:.|.::. .|.|    :..:.:|..:||::..
Mouse   254 LFWAKTIAKKVGCPTED---TGKMAACLKITDPRALTLAY-KLPVKKQEYPVVHYLAFIPVIDGD 314

  Fly   309 SPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLN 373
                |:.:||::.:  .....:.:|..:::..|                         |:...::
Mouse   315 ----FIPDDPINLY--NNTADIDYIAGINNMDG-------------------------HLFATID 348

  Fly   374 LPEGTPVQMVSEILDAYDFKGDSLNNDTMLK-LAEISGDFNFYY------PIYETISSYVTYANL 431
            :|   .|....:.:...||. ..::..|:.| |......|:.|.      |..|.:..  |....
Mouse   349 VP---AVDKTKQTVTEEDFY-RLVSGHTVAKGLKGAQATFDIYTESWAQDPSQENMKK--TVVAF 407

  Fly   432 EENPLFIYIFEFAGLNSITKFFAGTTDDYG---------------LGAVHMDDGLHTIRIPVSFD 481
            |.:.||:...|.|....  |..|.:...|.               :||.|.||..:....|.: .
Mouse   408 ETDVLFLIPTEIALAQH--KAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFA-T 469

  Fly   482 DFPKDSEDAKVIQRMSSLMTDFAKTG 507
            ......:|..|.:.|.:..|:||::|
Mouse   470 PLGYRPQDRAVSKAMIAYWTNFARSG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	145/516 (28%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/111 (46%)
Cel	NP_034015.1	COesterase	26..542	CDD:278561	146/524 (28%)
		Aes	<117..>247	CDD:223730	62/130 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..599
		4 X 11 AA tandem repeats, O-glycosylated region	559..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740