Protein Alignment Jhedup and Nlgn2

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 606
• Identity: 161/606 - (26%)
• Similarity: 251/606 - (41%)
• Gaps: 154/606 - (25%)

  Fly    41 GEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGV------- 98
            |....|:|:|:|.||:|..|.:.|.....|.||.:|.....:|.|..:.|....::.|
  Rat    64 GPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLE 128

  Fly    99 ----------EDCLYLNVYRP-------KNRAE-------------DKLPVMVYIHGGGFFSGSA 133
                      |||||||:|.|       |.|.|             .|.|||:::|||.:..|:.
  Rat   129 AAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTG 193

  Fly   134 HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDP 198
            : |..| ..|.....|::.|:|||||..|||||||:...||:|..||..||:|:.::||.|||||
  Rat   194 N-MFDG-SVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDP 256

  Fly   199 KKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQA 263
            :::|:.|..||....:|.::|.:|:||||.:::.:||. :|:..:...||...|.|..::..|:.
  Rat   257 ERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTA-ISSWSVNYQPLKYTRLLAAKVGCDRE 320

  Fly   264 ESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMP---HLTTLPVLEAP-SPDAFLVEDPLDAHRA 324
            :   |.:..|.||....::|   ||.    |..|   |:...||::.. .||     ||....:.
  Rat   321 D---STEAVECLRRKSSREL---VDQ----DVQPARYHIAFGPVVDGDVVPD-----DPEILMQQ 370

  Fly   325 GRINQMPWILSLSSRAGEGSLFI-----------MRAFINPKLRAEFN-ENFLEHMALLLNLPEG 377
            |.......::.::.  |||..|:           ..||       :|. .||:::   |...|||
  Rat   371 GEFLNYDMLIGVNQ--GEGLKFVEDSAESEDGVSASAF-------DFTVSNFVDN---LYGYPEG 423

  Fly   378 TPVQMVSEIL-----DAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLF 437
            ..|  :.|.:     |..|.....:...|:|.|..   |..:..|...|...:..|    ::|::
  Rat   424 KDV--LRETIKFMYTDWADRDNGEMRRKTLLALFT---DHQWVAPAVATAKLHADY----QSPVY 479

  Fly   438 IYIF----------EFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPV--SFDDFPKD--SE 488
            .|.|          |:|                  .|.|.|:..:...:|:  :.|.||.:  ..
  Rat   480 FYTFYHHCQAEGRPEWA------------------DAAHGDELPYVFGVPMVGATDLFPCNFSKN 526

  Fly   489 DAKVIQRMSSLMTDFAKTG-----------VFH------EESICKVSDFKEQGMCNYLHFGGNKE 536
            |..:...:.:..|:|||||           ..|      ||.:....:.||:   .|||.|....
  Rat   527 DVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEK---QYLHIGLKPR 588

  Fly   537 KYLEDIRNSITLTAFPIWKKL 557
                 :|::........|.:|
  Rat   589 -----VRDNYRANKVAFWLEL 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	149/549 (27%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	159/601 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836