DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and ache

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_571921.1	Gene:	ache / 114549	ZFINID:	ZDB-GENE-010906-1	Length:	634	Species:	Danio rerio

Alignment Length:	541	Identity:	161/541 - (29%)
Similarity:	246/541 - (45%)	Gaps:	100/541 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQ---RSY 88
            :|.::||.:|........||:|||:|:||:|..|.|...|.:||..|.:|....::|.|   .||
Zfish    35 LGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAEPKKPWNNVFEAKEFSNACYQFVDTSY 99

  Fly    89 FAKEWGLMGV----------EDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYL 143
                .|..|:          ||||||||:.|.......|.|||:|:||||:|||:........||
Zfish   100 ----PGFPGIEMWNPNRVMSEDCLYLNVWVPPTPRPQNLTVMVWIYGGGFYSGSSSLDVYDGRYL 160

  Fly   144 MDTNKVVMVTMNYRLGPFGFLS-TGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHS 207
            ..|.|||:|:||||:|.||||: .|....|||.|..||||||||:|::|..|||:||:||:.|.|
Zfish   161 AYTEKVVVVSMNYRVGAFGFLALNGSSDAPGNVGLYDQRLALQWVQENIHFFGGNPKQVTIFGES 225

  Fly   208 AGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARR----LGKELAIDQAESLSS 268
            ||..|..:|::||:|:.||..::..:|........:..|   :|||    |||.:.....   :.
Zfish   226 AGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFD---EARRRTTKLGKLVGCTWG---ND 284

  Fly   269 QDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEA----PSPDAFLVEDPLDAHRAGRINQ 329
            .:|.:.|||..|::|:.....:..|.::...:.:||::.    .:|||.:        .:|....
Zfish   285 TELIDCLRNKHPQELIDQEWQVLPWSSLFRFSFVPVVDGVFFPDTPDAMI--------SSGNFKY 341

  Fly   330 MPWILSLSSRAGEGSLFIM---RAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEIL---D 388
            ...:|.::.  .|||.|::   ..|..........|:|||  ::.:.:|....:.:.:.||   |
Zfish   342 TQILLGVNQ--DEGSYFLLYGAPGFSKDNESLISREDFLE--SVKMGVPHANDIGLEAVILQYTD 402

  Fly   389 AYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANL---------------------- 431
            ..|......|.|.|   .:|.||.|...|:.....||..||.|
Zfish   403 WMDENNGQKNRDAM---DDIVGDQNVICPLQHFAKSYAQYAALHAQSSAAAPGTLGWGNSGPTGY 464

  Fly   432 ----EENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKD------ 486
                ....:::|:|:....|.....:.|....|.:..|.   ||            |.:
Zfish   465 NSGNSHGAVYLYLFDHRASNLAWPEWMGVIHGYEIEFVF---GL------------PLEKRLNYT 514

  Fly   487 SEDAKVIQRMSSLMTDFAKTG 507
            :|:.|:.:|:.....:||:||
Zfish   515 AEEEKLSRRIMRYWANFARTG 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	160/537 (30%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	55/104 (53%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	161/541 (30%)
ache	NP_571921.1	AChE_tetra	598..631	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840