DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces1d

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	152/540 - (28%)
Similarity:	236/540 - (43%)	Gaps:	81/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGE-----FEAFMGIPFAQPPVGPLRLKNPVPN 67
            |.||:|.............:..::|.::..|.:.|     ...|:|||||:||:|.||...|.|.
  Rat     7 VWLFLAACTAWGYPSSPPVVNTVKGKVLGKYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPA 71

  Fly    68 EPWEGVLDAGAAKDSCIQRSYFAKEWG-----------LMGVEDCLYLNVYRPKNRAED-KLPVM 120
            |||..|.:..:....|.|.:...:...           |...|||||||||.|.:..:: :||||
  Rat    72 EPWNFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVM 136

  Fly   121 VYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQ 185
            |:|||||...|.|.....  :.|.....||:||:.||||.:||.||||||..||:|..||..||.
  Rat   137 VWIHGGGLVVGGASTYDG--QVLSAHENVVVVTIQYRLGIWGFFSTGDEHSQGNWGHLDQVAALH 199

  Fly   186 WIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQ 250
            |:|.:||.|||:|..||:.|.||||.|....::||.:|.||..::|.:|.:..||: |..|....
  Rat   200 WVQDNIANFGGNPGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSAL-ITTDSKPI 263

  Fly   251 ARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVW---------DNMPHLTTL--PV 304
            |..:.   .:...::.:|..:...||.....:||.:...|.::         ::.|.|.|:  .|
  Rat   264 ANLIA---TLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGV 325

  Fly   305 LEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRA-EFNENFLEHM 368
            :...:|:..|.|.        ..|.:|:|:.::.:.        ..:|.|.|.. ..:|..|:..
  Rat   326 VLPKTPEEILTEK--------SFNTVPYIVGINKQE--------FGWIIPTLMGYPLSEGKLDQK 374

  Fly   369 ALLLNLPEGTPVQMVSE-----ILDAYDFKG--DSLNNDTMLKLAEISGDFNFYYPIYETISSYV 426
            .....|.:..|...:||     :.:.| |.|  |......:.:  ::..|..|..|     |..|
  Rat   375 TAKSLLWKSYPTLKISEKMIPVVAEKY-FGGTDDPAKRKDLFQ--DLVADVMFGVP-----SVMV 431

  Fly   427 TYANLEEN-PLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKD---S 487
            :.::.:.. |.|:|.||:.     ..|.:.......:|. |.|:.......|     |.||   .
  Rat   432 SRSHRDAGAPTFMYEFEYR-----PSFVSAMRPKTVIGD-HGDELFSVFGSP-----FLKDGASE 485

  Fly   488 EDAKVIQRMSSLMTDFAKTG 507
            |:..:.:.:.....:||:.|
  Rat   486 EETNLSKMVMKYWANFARNG 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	148/517 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/104 (50%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	148/523 (28%)
		Aes	<121..>239	CDD:223730	58/119 (49%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950