DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and CES1

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001020366.1	Gene:	CES1 / 1066	HGNCID:	1863	Length:	568	Species:	Homo sapiens

Alignment Length:	564	Identity:	159/564 - (28%)
Similarity:	252/564 - (44%)	Gaps:	111/564 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMG------------- 97
            |:|||||:||:||||...|.|.|||..|.:|.:....|.|.   .|...|:.
Human    51 FLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQD---PKAGQLLSELFTNRKENIPLK 112

  Fly    98 -VEDCLYLNVYRP-----KNRAEDKLPVMVYIHGGGFFSGSAHP---MASGPEYLMDTNKVVMVT 153
             .|||||||:|.|     |||    |||||:|||||...|:|..   :|     |.....||:||
Human   113 LSEDCLYLNIYTPADLTKKNR----LPVMVWIHGGGLMVGAASTYDGLA-----LAAHENVVVVT 168

  Fly   154 MNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMI 218
            :.||||.:||.||||||..||:|..||..||:|:|.:||:|||:|..||:.|.||||.|..:.::
Human   169 IQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVL 233

  Fly   219 SPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQ-AESLSSQDLAEALRNVCPKK 282
            ||.:|.||..::|.:|....|.:....|    .:.|.:::||.. .::.:|..:...||....::
Human   234 SPLAKNLFHRAISESGVALTSVLVKKGD----VKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEE 294

  Fly   283 LLVSVDSLKVW---------DNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSS 338
            ||.:...:|..         ::.|.|.|  |::.    ..|::.|.:.......:.:|:::.::.
Human   295 LLETTLKMKFLSLDLQGDPRESQPLLGT--VIDG----MLLLKTPEELQAERNFHTVPYMVGINK 353

  Fly   339 RAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPV-----QMVSEILDAYDFKGDSLN 398
            :. .|.|..|:....|     .:|..|:....:..|.:..|:     :::.|..:.| ..|   .
Human   354 QE-FGWLIPMQLMSYP-----LSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKY-LGG---T 408

  Fly   399 NDTMLK---LAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTT--D 458
            :||:.|   ..::..|..|..|      |.:...|..:.....|::||....|.:......|  .
Human   409 DDTVKKKDLFLDLIADVMFGVP------SVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIG 467

  Fly   459 DYG------LGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESICKV 517
            |:|      .||..:.:|              ...|:.::.:.:.....:||:.|..:.|.:...
Human   468 DHGDELFSVFGAPFLKEG--------------ASEEEIRLSKMVMKFWANFARNGNPNGEGLPHW 518

  Fly   518 SDFKEQGMCNYLHFGGNKE--KYLEDIRNSITLTAFPIWKKLFA 559
            .::.::.  .||..|.|.:  :.|:|..     .||  |..|||
Human   519 PEYNQKE--GYLQIGANTQAAQKLKDKE-----VAF--WTNLFA 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	145/509 (28%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	55/111 (50%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	155/557 (28%)
CES1	NP_001020366.1	Aes	<122..>240	CDD:223730	61/126 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850