DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces2a

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	521	Identity:	164/521 - (31%)
Similarity:	250/521 - (47%)	Gaps:	69/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTL--MPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYF- 89
            |.:||:.  :...:|| ..||:|||||:||||.||...|...|||.||.|..:....|:|....
Mouse    39 GQVRGSFVHVKDTKSG-VHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQPDIMN 102

  Fly    90 ---AKEWGLM-----GVEDCLYLNVYRPKNRAE-DKLPVMVYIHGGGFFSGSAHPMASGPEYLMD 145
               |||..|:     ..|||||||:|.|.:..| ..|||||:|||||...|||  ..:....|..
Mouse   103 LEDAKEMNLILPPISMSEDCLYLNIYTPTHAQEGSNLPVMVWIHGGGLVVGSA--SMNDVSKLAA 165

  Fly   146 TNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGG 210
            |.::|:|.:.||||..||.||||:|..||:|:.||..||:|:||:||.|||:..:||:.|.||||
Mouse   166 TEEIVIVAIQYRLGVLGFFSTGDQHARGNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGG 230

  Fly   211 ISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARR-LGKELA-IDQAESLSSQDLAE 273
            .|...|::||.|||||.      |.:..|.:.:|.|.:|.... :.|.:| :...|:..|:.|..
Mouse   231 TSVSSHILSPMSKGLFH------GAIMQSGVALLPDLISDTSEVVYKTVANLSGCEATDSEALIH 289

  Fly   274 ALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSS 338
            .||....:::|......|            ::.|.....||.:.|.:...:...:.:|.|:.:::
Mouse   290 CLRAKSKQEILAINQVFK------------MIPAVVDGEFLPKHPQELLTSMDFHPVPSIIGVNT 342

  Fly   339 -RAGEG-SLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDT 401
             ..|.| .:|:....|...:..|.....|::.|..:.||......:|.|      :.||:.:.:|
Mouse   343 DECGWGVPMFMGLDHIIKNITRETLPAVLKNTAARMMLPPECSHLLVEE------YMGDTEDPET 401

  Fly   402 M-LKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAV 465
            : .:..|:.|||.|..|..:.       |:.:.:...:|.:||..|:|..|....:    .:.|.
Mouse   402 LQAQFREMLGDFMFVIPALQV-------AHFQRSQAPVYFYEFQHLSSFIKHVRPS----HVKAD 455

  Fly   466 HMDDGLHTIRIPVSFDDFPKD-----SEDAKVIQR-MSSLMTDFAKTGVFHEESI--CKVSDFKE 522
            |.||      :...|..:..|     :|:.::::| |.....:||:.|..:.|.:  ..|.|..|
Mouse   456 HGDD------VAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPNSEGLPSWPVLDHDE 514

  Fly   523 Q 523
            |
Mouse   515 Q 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	157/499 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/104 (49%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	164/521 (31%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	51/104 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840