DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and ache

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	161/532 - (30%)
Similarity:	244/532 - (45%)	Gaps:	75/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEG 72
            :||..|:...|...:.....|.:||...| ..|....||:|||||:|||..:|.:...|.:||..
Frog    16 LLLVPALTQSDGGLLVSTRSGKVRGLRQP-VLSTHVSAFLGIPFAEPPVDKMRFRRSEPKKPWTD 79

  Fly    73 VLDAGAAKDSCIQRSYFAKEW-GLMGV----------EDCLYLNVYRPKNRAEDKLPVMVYIHGG 126
            |.||.|..::|.|  ||...: |..|:          |||||||::.|..|..: ..|||:|:||
Frog    80 VWDATAYPNACYQ--YFDTLYPGFPGMEMWNPNRPMSEDCLYLNIWVPHPRPSN-ATVMVWIYGG 141

  Fly   127 GFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGF--LSTGDEHMPGNFGFKDQRLALQWIQK 189
            ||:|||:........||.....|::|:||||:|.|||  |:.|....|||.|..||||||||:|.
Frog   142 GFYSGSSSLDVYDGRYLCHAENVIVVSMNYRVGAFGFLTLTPGSVDAPGNVGLFDQRLALQWVQD 206

  Fly   190 HIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARR- 253
            :||.|||||:.||:.|.|||.:|..:|::||.|..||..:...:|:.......|..   .:|||
Frog   207 NIAFFGGDPRTVTIFGESAGAVSVGMHVLSPGSHHLFSKAALQSGSPNTPWATITP---QEARRR 268

  Fly   254 ---LGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDA-FL 314
               |||.|   .....:..:|...||...|::|:....|:     :|..:.......|.||| |.
Frog   269 TELLGKFL---DCRMGNDTELLNCLRVKQPQELIDHEFSV-----LPAPSVFRFAFVPVPDADFF 325

  Fly   315 VEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALL----LNLP 375
            .|.|......||....|.|:.::.  .|||.|::  :..|.. ::.||:.:.....|    :::|
Frog   326 PEPPEILMNMGRFKPCPLIMGVNQ--NEGSYFLL--YGAPGF-SKNNESLITREEFLGGVKMSVP 385

  Fly   376 EGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTY--ANLEE--NPL 436
            :...:.:.:.::...|:..:.........:.::.||.|...|:        ||  ..:.|  |.:
Frog   386 QANDIALEAVVMQYTDWADEHAGVKNREAMDQLVGDHNVICPL--------TYFAGKVAETGNRV 442

  Fly   437 FIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDS------EDAKVIQR 495
            :.|.|:....|.....:.|....|.:..|.   ||            |.|:      ::..:.:|
Frog   443 YTYFFDHRASNLAWPQWMGVPHGYEIEFVF---GL------------PLDANLNYTPQEEALSRR 492

  Fly   496 MSSLMTDFAKTG 507
            |.....:||:||
Frog   493 MMRYWANFARTG 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	156/509 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/105 (50%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	157/517 (30%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910