DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and si:ch211-71n6.4

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_009292113.1	Gene:	si:ch211-71n6.4 / 100148657	ZFINID:	ZDB-GENE-091204-213	Length:	596	Species:	Danio rerio

Alignment Length:	580	Identity:	161/580 - (27%)
Similarity:	240/580 - (41%)	Gaps:	137/580 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFAGFGVLLFVAVA-----VGDSLDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLR 60
            |...|.||:..:.:|     |..:....:.::....|.|...::.|.: :|.|||:|.|||..||
Zfish    45 MFLIGCGVIALLTLAGYLAYVAKTSPPRVAEVQTECGWLHGQWKDGAY-SFKGIPYAVPPVDELR 108

  Fly    61 LKNPV----PNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAEDKLPVMV 121
            .|.|.    ..:.|||..||...:..|.|.....|:..:||.||||:|:|:.|.......|||||
Zfish   109 WKPPENLVDAGKCWEGKYDATHFRSICAQVQPLQKDGKVMGEEDCLHLSVWTPSLHPAKPLPVMV 173

  Fly   122 YIHGGGFFSGSAHPMASGP-EYLMDTNKVVMVTMNYRLGPFGFLST------GDEHMPGNFGFKD 179
            :||||.....|.......| |.|.:..::|.|::||||..|||::.      ...:..||:||.|
Zfish   174 WIHGGYLHMLSGQEKGYSPTEELAERTQMVYVSLNYRLNAFGFMALEMFREGSPTNSSGNYGFMD 238

  Fly   180 QRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAM--K 242
            |..||||:|::|..|||||.:||:.|.|:||.|....|:||.:||||..::.::|:...:|.  .
Zfish   239 QIQALQWVQRNIHHFGGDPGRVTIFGQSSGGTSVWTLMMSPLAKGLFHGAIDMSGSYVYNASLES 303

  Fly   243 ILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMP-----HLTTL 302
            ..||.|...||.|.:.|:    .|...::|:.|:.:             .|...|     .|..|
Zfish   304 AEKDNLEFLRRTGCKDAL----CLRRLNIAQVLQAI-------------PWQQYPSWAADDLVDL 351

  Fly   303 P---------------VLEAPSPDAFLVEDPLDA-HRAGRINQMPWIL--------------SLS 337
            |               |||||         |.:: .:.|..|.:|:::              ::|
Zfish   352 PVKGVFVGPVAVIDGHVLEAP---------PFESWEKRGAFNDVPFVVGTTEQETDFGPPYKNIS 407

  Fly   338 SRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLN----------LPEGTPVQMVSEILDAYDF 392
            :...|...:|:::.::|     |.||.......|.|          .||.....|||      |.
Zfish   408 AWIWEDYRWIVKSKLSP-----FGENVTSQALKLYNSSAPCPTSDRCPERLFTTMVS------DM 461

  Fly   393 KGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYA-NLEENPL----FIYIFEFAGLNSITKF 452
            |.....||...:.|..     ...|:|..:   |||. :.:.||.    |...|.|..|:|:. |
Zfish   462 KASCPRNDLAKRAAGA-----LKSPVYRYL---VTYTPSKQANPSSWLPFPSRFAFHLLDSLA-F 517

  Fly   453 FAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEE 512
            |.|.  :..||.:...|        :.|.:.            ::.....|||.|...||
Zfish   518 FRGL--EMALGTLSPAD--------IDFQEM------------ITKYFVYFAKEGRMPEE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	152/539 (28%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	45/110 (41%)
si:ch211-71n6.4	XP_009292113.1	Abhydrolase	75..559	CDD:304388	155/550 (28%)
si:ch211-71n6.4	XP_009292113.1	Aes	<158..>269	CDD:223730	45/110 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575493
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940