DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and nlgn1

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_017213657.1	Gene:	nlgn1 / 100002610	ZFINID:	ZDB-GENE-090918-1	Length:	867	Species:	Danio rerio

Alignment Length:	706	Identity:	166/706 - (23%)
Similarity:	260/706 - (36%)	Gaps:	231/706 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GVLLFVAVAVGDSLD----VCLEDMGCMRG--------TLMPGYQSGEFEAFMGIPFAQPPVGPL 59
            |:.|...:|..:.||    :.....|.:||        .|.|..|      |:|:|:|.||.|..
Zfish    36 GLALHAQLAASEKLDETDPIVTTTYGKVRGFKKELNNEILGPVIQ------FLGVPYAAPPTGER 94

  Fly    60 RLKNPVPNEPWEGVLDAGAAKDSCIQ-----------------------RSYFAKEWGLMGVEDC 101
            |.:.|.|...|..:.:|......|.|                       .||...:     .|||
Zfish    95 RFQPPEPPISWSEIRNATQFAPVCPQTLLEGRLPDVMLPVWFTNSIEVVSSYVQDQ-----SEDC 154

  Fly   102 LYLNVYRP------------------------------------KNRAEDK--------LPVMVY 122
            |:||:|.|                                    .:.|||:        .||||:
Zfish   155 LFLNIYVPTEDVKRISKECARKPGKKICRKGGPLSKKQNDDLADNDGAEDEDIRESGSPKPVMVF 219

  Fly   123 IHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWI 187
            :|||.:..|:.: |..| ..|.....|:::|:|||||..|||||||:...||:|..|...||:|.
Zfish   220 VHGGSYMEGTGN-MFDG-SILASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWT 282

  Fly   188 QKHIATFGGDPKKVTVLGHSAGGISAHLHMI---------SPNSKGLFQNSMSLTGTMFLSAMKI 243
            .::||.|||||.::||.|..||....:|..:         |.::|||||.:::.:||. ||:..:
Zfish   283 SENIAFFGGDPLRITVFGSGAGASCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTA-LSSWAV 346

  Fly   244 LKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMP---HLTTLPVL 305
            ...|...||.|.|::..:..:::   ::.|.|:....|:|:..       |..|   |:...||:
Zfish   347 SFQPAKYARMLAKKVGCNLKDTV---EMVECLQKKHYKELVEQ-------DIQPARYHIAFGPVI 401

  Fly   306 EAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNE------NF 364
            :..    .:.:||......|..  :.:.:.|....|||..|: ...::.:...:.|:      :|
Zfish   402 DGD----VIPDDPQILMEQGEF--LNYDIMLGVNQGEGLKFV-ELIVDNENGVQANDFDYAVSSF 459

  Fly   365 LEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLK-----------------LAEISGDF 412
            ::.   |...|||..: :...|...|....|..|.:|..|                 .|::...|
Zfish   460 VDD---LYGYPEGKDI-LRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSSF 520

  Fly   413 ---NFYYPIY-----ETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDD 469
               .::|..|     |.:..:...|:.:|.|   |:|   ||..|     |.|:.:
Zfish   521 GSPTYFYAFYHHCQTEQVPPWADAAHGDEIP---YVF---GLPMI-----GPTELF--------- 565

  Fly   470 GLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTG-----------VFHEESICKVSDFKEQ 523
                   |.:|     ...|..:...:.:..|:|||||           ..|    .|.:.|:|.
Zfish   566 -------PCNF-----SKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH----TKPNRFEEV 614

  Fly   524 GMCN-------YLHFGGN---KEKY-----------------LEDIRNSITLTAFP 552
            ....       |||.|..   ||.|                 |.::...|:.|..|
Zfish   615 AWTRYNQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHSLNEVSQIISTTKLP 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	145/605 (24%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	48/147 (33%)
nlgn1	XP_017213657.1	COesterase	53..647	CDD:306613	157/664 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740