DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asph and AIP5

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_116671.1	Gene:	AIP5 / 850570	SGDID:	S000001912	Length:	1233	Species:	Saccharomyces cerevisiae

Alignment Length:	961	Identity:	189/961 - (19%)
Similarity:	327/961 - (34%)	Gaps:	340/961 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RKRKDKRRK---RDDDESSHGVHITKMGNEDLHLHVHHDHGTGGHWCAKIIFFALMAVLLGL--- 66
            |::|:|::|   |....||:....|.:..:.                      .|.::|:|:
Yeast   184 RRKKNKKKKTTNRRGRNSSNPADTTDLSKQS----------------------TLDSILVGIEEY 226

  Fly    67 ------------VGLIIMENRGLEDLDTPLSESRFSKVFD-----------------GWVDEHRD 102
                        |.::..|...:|.:|.........|.||                 ..::|.:.
Yeast   227 LQEDGSKNEDIKVNIVQDEPVNVEKMDIRTRNESSDKTFDIDVPNKDNVDETSSKSENNINEEKA 291

  Fly   103 EH-------------DGHDVQ-----EPSG-EALDDHDEHDDHDDHEDEEPLTEE----LEEELE 144
            ||             :|:...     ||.| ||.|::.:....|  .:.|.||:.    .|.|.:
Yeast   292 EHTLPREENEILNVNEGNAASFKHQLEPHGLEAGDENGQASTKD--VESESLTKNGFNFKENESK 354

  Fly   145 E----EEEPTEEDEPAADE-------------------EYEEDEDE----------ENNAGENIT 176
            .    |::.||.|......                   |.::.|||          |||...|..
Yeast   355 HLKAGEKQQTESDRDGISPSVLAKNQKETEIGKEDHVFEQKDKEDEKCRKELSVNHENNMSHNFN 419

  Fly   177 AEDAEE----EEEEEDNDDE-----------------GTVEATVEATTEATTEATGEYEAEEDDE 220
            |..::.    |.|.|..|||                 ||.:.:||...|       |.|.||::|
Yeast   420 AAGSDSIIPPETERETYDDETMGPTKRISDNEKNLQHGTNDISVEVEKE-------EEEEEEEEE 477

  Fly   221 D---------------EAAADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIEESVEPERSQYAAQ 270
            :               ||..:::...:.|...||.||....:::..|..|....:|.|.|..:|:
Yeast   478 NSTFSKVKKENVTGEQEAVRNNEVSGTEEESTSKGEEIMGGDEKQSEAGEKSSIIEIEGSANSAK 542

  Fly   271 SAPAKDN---NDDDDDDDQDKN--------DADDGDDDEFESLAQQFEND--PEDTVPAKAVESE 322
            .  :|||   .|:.:...|:..        |..|...|:.| :.:..|.:  |||...||    |
Yeast   543 I--SKDNLVLEDEAEAPTQENKPTEVVGEIDIPDAPRDDVE-IVEAVEKNIIPEDLEVAK----E 600

  Fly   323 EQDQDQADEEEP-----------------------KEEGSSWLASLAVKFGVGVALALVSRLVLI 364
            :|:.:|...:||                       |:||::.|::...|..|.......:..|.:
Yeast   601 DQEGEQVKLDEPVKAMKDDKIAMRGAESISEDMKKKQEGTAELSNEKAKKEVDETARESAEGVEV 665

  Fly   365 RKSPNTTEDEPAPETIFRRRLTIATAEDHIPDDVEELPPLDDEYSEEEIEI-EEEIEVEI-SDIE 427
            .|| .|.|   :|:.:  :|.|....||      .::...|.|..:|::.: :|:::.|| :.||
Yeast   666 EKS-KTPE---SPKVV--KRCTSGRPED------LQINERDPEVLKEDVRVPDEDVKPEIATTIE 718

  Fly   428 EEEEE----------------VRHDNDDNVASMASY----VPETFEQLSAMYKYAQEPTK----D 468
            ..|||                .:.|..| |.|..|:    .|:.||......|...:.|.    :
Yeast   719 NSEEEDPKSQRVQISTEQAETTQKDMGD-VGSTTSFKEEEKPKRFEITQEGDKITGKDTNHEHGE 782

  Fly   469 AKPEQKEKEPEKPVGHSDIYVE----------YEDGAIEDYEH-------------DGVSDEEIT 510
            |.....|......||.::.|:|          .||..:|:.|.             |...:.|:|
Yeast   783 ATEAASENSKASDVGTAEKYIEPSSESVKKDTEEDAEVENSEKTEFIKVKAELENLDAPKEAEVT 847

  Fly   511 ------DEEDEISDVDDADLMNRLEAKYGRLPVKEFESDPDSDDPSWTQIKPKEAAPAPAEKEDP 569
                  :|:.|:...:||::.|                   |:...:.::| .|.....|.||..
Yeast   848 AELNKENEDVEVDTEEDAEVEN-------------------SEKTEFIKVK-AELGNLDAPKEAE 892

  Fly   570 FEQELRKANEEMIRENYAQALRSFNTLTTNFAHEP-------SAHLGRARLLELLAKKERS--NQ 625
            ...||.|.||::  |..|.:.....|..:..|..|       .|.:.: :..|.:.|::.:  |.
Yeast   893 VTAELNKENEDV--EVAATSKEDIETKCSEPAETPIEDGTCTEAEVSK-KDAEAVTKEDENMENS 954

  Fly   626 RLWEAI---------------DAYKRYLAFGELVASNQEFQTAGESCIENLRFLGHHRQATTIHE 675
            ::.||:               |.::|.:...||...:.:.....:..:|    :....:.|::.:
Yeast   955 KIAEALKDVTGDQEIDDINISDEFQRTVELPELEKQDIKDNKGEDKELE----VEETEKETSLPD 1015

  Fly   676 LLI--------NRLPEDPRLRNQLSLTYLMVNNLQQVEKVAVETLKLWPNN 718
            |::        |.:.::....:||..     |..:.:.|.|       |||
Yeast  1016 LVVEENITEEKNEIKQEEEEVSQLDF-----NETESISKEA-------PNN 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	21/134 (16%)
		TPR repeat	684..714	CDD:276809	5/29 (17%)
		TPR repeat	719..748	CDD:276809	189/961 (20%)
		TPR repeat	757..782	CDD:276809
		Asp_Arg_Hydrox	826..977	CDD:282913
AIP5	NP_116671.1	2A1904	<271..>528	CDD:273344	53/265 (20%)
AIP5	NP_116671.1	PTZ00121	<482..1082	CDD:173412	126/632 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900