DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asph and Rp1

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_008761780.1	Gene:	Rp1 / 681377	RGDID:	1596713	Length:	2150	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	131/823 - (15%)
Similarity:	251/823 - (30%)	Gaps:	255/823 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 DDHDDHEDEEPLTEELEEELEEEEEPTEEDEPAADEEYEEDEDEENNAGENITAEDAEEEEEEED 188
            |..|.:|.:...:.:...:|..:.....:....:|::|...|:.:|...:.|..:......::||
  Rat  1382 DSIDKNESDISTSSQNVNKLSSQGIFLSKTHLDSDKDYSPLEEFQNCPPKKIVNKKKSVSSDKED 1446

  Fly   189 NDDEGTVEATVEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQEDDEDEDEEE 253
            :.......:...:.|.:...||.|.|:.|:.|.:    |..:.:.:....:...:|..:.|.|..
  Rat  1447 SRTSEEPRSITNSVTSSERNATSELESFEESESQ----DTGIFNMKVRTEEKAAKESMQKESEAR 1507

  Fly   254 QEIE-------ESVEPERSQYA-------AQSAPAK-----DNNDD------------------D 281
            ..:|       ..:|..|...|       .|..|..     |:|.:                  |
  Rat  1508 MSLELINISGRNIIEQGRRNTAFLETTGRGQVTPPSLVFCYDSNKNTEKEMSVGETKMRVKKIVD 1572

  Fly   282 DDDDQDKNDADDGDDDEFESLA----QQFENDPEDTVPAKAVESEEQDQDQADEEEPKEEGSSWL 342
            ..:::...|:....:.:..|..    ..:.:|.|...|.||:..|..|....:.|.|:
  Rat  1573 SMENESYTDSSLNCNKQHRSPGTLDWSDYGSDSESRYPCKALSYEHSDDTGQEREYPR------- 1630

  Fly   343 ASLAVKFGVGVALALVSRL---VLIRKSPNTTEDEPAPETIFRRRLTIATAEDHIPDDVEELPPL 404
                     |:....:.:|   ..|.|.|           .|...:..:....:.|.:|..:...
  Rat  1631 ---------GIVRRAIEKLYGKAEIIKPP-----------FFHGSIHKSQVCPYNPVEVPCVKKT 1675

  Fly   405 DDEYSE-EEIEIEEEIEVEISDIEEEEEEVRHDNDDNVASMA-SYVPETFEQLSAMYKYAQEPTK 467
            ....|| :.:...|::......::|.:||.:.:.|.|  .|. |:...:.|:::
  Rat  1676 HFYESECQSLVSSEQVSRSSLMLQEFQEERQSEVDAN--GMGDSFGDSSIEKVT----------- 1727

  Fly   468 DAKPEQKEKEPEKPVGHSDIYVEYEDGAIED---------------YEHDGVSDEEITDEEDEIS 517
                        ||..|..:::|.|.|.:.|               .::.|:.....|...|.:.
  Rat  1728 ------------KPSEHGRVFMEKEKGKLIDNGKWLLRENHLWRVSLDNPGMYGNADTTSVDTLM 1780

  Fly   518 DVDDADLMNRLEAKYGRLPVKEFESDPDSDDPSWTQIKPKEAAPAP--AEKEDPFEQELRKANEE 580
            |      .|.:|..|...                     .|.||.|  ||......:|:.:..|
  Rat  1781 D------KNSIEVPYSHF---------------------GELAPGPTMAELSSSEIEEMTQPLE- 1817

  Fly   581 MIRENYAQALRSFNTLTTNFAH----EPSAHLGRARLLELLAKKERSNQRLWEAIDAYKRYLAFG 641
             ::.||           .||.|    ||                                   ||
  Rat  1818 -VKCNY-----------FNFPHGSDSEP-----------------------------------FG 1835

  Fly   642 ELVASNQEFQTAGESCIENLRFLGHHRQATTIHELLINRLPEDPRLRNQLSLTYLMVNNLQQVEK 706
            |      :|..|..:.....:...||::.        .|.....|....::.|:....|  :|..
  Rat  1836 E------DFLDAQNTNCPKEKIPNHHKEE--------KRNSPSERTCTPVTQTFASAGN--KVHP 1884

  Fly   707 VAVETLKL--WPNNAVAQ--LHYGLALRQFHADYAKALPYLKYAVESGEEGTQEAFFYLSLGETM 767
            |..:.:|.  .|.:::..  |..|.:|.:.:|...:..|.|...::...| ....|.|....:..
  Rat  1885 VCSDVIKTQPLPGSSITHGALQEGDSLDKLYALCGQHCPILTVIIQPVNE-EDRGFAYRKDSDIE 1948

  Fly   768 QRLSMKSEALEVYGKGVAKGFFASLYQRSLYNEPRLRAQPF-WQPKETGYERQLEKLTLNWRAIR 831
            ..|..:. .:|:|                          || .|.|:..:..:..|:.:. :...
  Rat  1949 NSLGFQL-WMEIY--------------------------PFLLQSKKNMFTSESRKVNVG-KQFT 1985

  Fly   832 DEGLALLGRSGFFEDEAEL-------LRDKGVWQQYELYAQGR 867
            |..:..|....:|::..:|       ||::....:.:||.:.|
  Rat  1986 DNAIGNLCDRLYFKNMIDLVDKRANSLREEVNLNKVQLYLKKR 2028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	38/255 (15%)
		TPR repeat	684..714	CDD:276809	5/29 (17%)
		TPR repeat	719..748	CDD:276809	6/30 (20%)
		TPR repeat	757..782	CDD:276809	5/24 (21%)
		Asp_Arg_Hydrox	826..977	CDD:282913	9/49 (18%)
Rp1	XP_008761780.1	DCX	60..135	CDD:176357
Rp1	XP_008761780.1	DCX	182..257	CDD:176357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900