Protein Alignment Asph and ASPHD2

DIOPT Version :9

• Sequence 1: NP_001261020.1
• Gene: Asph / 36778
• FlyBaseID: FBgn0034075
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_065170.2
• Gene: ASPHD2 / 57168
• HGNCID: 30437
• Length: 369
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 88/340 - (25%)
• Similarity: 130/340 - (38%)
• Gaps: 93/340 - (27%)

  Fly   683 EDPRLRNQLSLTYLMVNNLQQVEKV-----------AVETLKLWPNNAVAQLHYGLALRQFH--A 734
            |.||       .|:.||:|.|....           :.|.::...|.       ||..:.:|  .
Human    81 EQPR-------PYVSVNSLMQAADANGLQNGYVYCQSPECVRCTHNE-------GLNQKLYHNLQ 131

  Fly   735 DYAKALPYLKYAVESG----EEGTQEAFFYLSLGETMQRLSMKSEALEVYGKGVAKGFFASLYQR 795
            :|||...:      ||    .:|.:|...||:...::|:..:               ||.
Human   132 EYAKRYSW------SGMGRIHKGIREQGRYLNSRPSIQKPEV---------------FFL----- 170

  Fly   796 SLYNEPRLRAQPFWQPKETGYERQLEKLTLNWRAIRDEGLALLGRSGFFEDEAELLRD------- 853
                 |.|...|::  .....:..:|.|..|::.|..|          ||...:...:
Human   171 -----PDLPTTPYF--SRDAQKHDVEVLERNFQTILCE----------FETLYKAFSNCSLPQGW 218

  Fly   854 ------KGVWQQYELYAQGRRVKDNCRRAPITCSLLEEFPESAGCR-RGQVKFSVMQAKTHVWPH 911
                  .|.|..:.|..||..|..|||:.|.|..||.......|.. .|....||:...|.:..|
Human   219 KMNSTPSGEWFTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEH 283

  Fly   912 CGPTNCRLRAHLTLAAPEPEKASLRVAEQERTWREGELFIFDDSFEHEVWHNGSQS---RLVLIL 973
            .||||.|:|.||.|..  |....|.|..:.:.|.||...:|||||.|..:|.||..   |:|.::
Human   284 YGPTNIRIRCHLGLKT--PNGCELVVGGEPQCWAEGRCLLFDDSFLHAAFHEGSAEDGPRVVFMV 346

  Fly   974 DMWHPQLSAAQRRSL 988
            |:|||.::||:|::|
Human   347 DLWHPNVAAAERQAL 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	35/200 (18%)
		TPR repeat	684..714	CDD:276809	8/40 (20%)
		TPR repeat	719..748	CDD:276809	6/30 (20%)
		TPR repeat	757..782	CDD:276809	3/24 (13%)
		Asp_Arg_Hydrox	826..977	CDD:282913	51/167 (31%)
ASPHD2	NP_065170.2	Asp_Arg_Hydrox	192..351	CDD:398678	52/170 (31%)
		2-oxoglutarate binding. /evidence=ECO:0000250	292..294		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3555
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700