Protein Alignment Asph and leo1

DIOPT Version :9

• Sequence 1: NP_001261020.1
• Gene: Asph / 36778
• FlyBaseID: FBgn0034075
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_996950.1
• Gene: leo1 / 404599
• ZFINID: ZDB-GENE-040426-2435
• Length: 696
• Species: Danio rerio
• Alignment Length: 695
• Identity: 130/695 - (18%)
• Similarity: 212/695 - (30%)
• Gaps: 280/695 - (40%)

  Fly    94 DGWVD-EHRDEHDG----HDVQEP--------SGEALDDHDEHDDHDDHEDEEPLTEELEEELEE 145
            ||..| |.||...|    .|.:.|        |..|..|.| |||.:|.:..:|..:||..:..|
Zfish    11 DGDSDNEQRDSGSGSGSDSDHERPRSASNASGSESAQSDRD-HDDDEDEDGGKPSNKELFGDDSE 74

  Fly   146 EEEPTE---EDEPAADEEYEEDEDEENNAGENITAEDAEEEEEEEDNDDEGTVEATVEATTEATT 207
            :|..::   .....:...........::...:..::.:..:.|...|..:.|:.:..|   .:.:
Zfish    75 DEHGSQHSGSQHSGSRHSGSRHSGSRHSGSRHSGSQHSGSQSERSGNQSDATMHSDNE---HSMS 136

  Fly   208 EATGEYEAEEDDEDEAAADDDAVESTE-------------------------APLSKA------- 240
            ||   :..|:||||    |||....::                         :|.|:|
Zfish   137 EA---HRGEQDDED----DDDRGHRSDVGSPASGAGSRRSDRGSGSPGSEAGSPRSEAGSGHSDP 194

  Fly   241 --------------------------EEQEDDEDEDEEEQEIEESVEPERSQYAAQSAPAKDNND 279
                                      .:|.:|||:.:...:..|..:.|..:..::|....|:.|
Zfish   195 GTPHTDGEGSGKDAHSGDEKWGGDGKSDQSEDEDKQQNSDDERERSDEEGERQKSESIKGSDSED 259

  Fly   280 D-----------DDDDDQD-------KNDADD--GDDDEFESLAQQFENDPEDTV-PAKAVESEE 323
            |           |.|.|.|       |..|:|  |:.|:..|     ::|.|..: |.:.:::::
Zfish   260 DFTRKKKKKIASDSDSDSDAETQGGKKPAANDLFGEADDISS-----DSDAEKPLTPGQPLDADD 319

  Fly   324 QDQDQADEEEPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIA 388
            ..:....||||..|....:....|...:|..|..|       |.||....||.
Zfish   320 GMEGDQPEEEPAPETRIEVEIPKVSTDLGSDLYFV-------KLPNFLSVEPR------------ 365

  Fly   389 TAEDHIPDDVEELPPLDDEYSEEEIEIEEEIEVE---------------ISDIEEEEEEVRHDN- 437
                          |.|.:|.|:|.|.||.::.|               .|..:||..||:..|
Zfish   366 --------------PFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRSRRDEEGNEVKESNA 416

  Fly   438 ----------------------------DDN---------------------------------- 440
                                        |.|
Zfish   417 RIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRK 481

  Fly   441 ----------------VASMASYVPETFEQLSAMYKYAQEPTK------DAKPEQKEKEPEKPVG 483
                            :..||...||:  |.:.|.|..:|..:      ..:...:||:.::.:.
Zfish   482 MTLSLADRCSKTQKIRILPMAGRDPES--QRNEMIKKEEERLRASIRRESQQRRMREKQHQRGLN 544

  Fly   484 ----HSDIYVEYEDG-------AIED-YEHDGVSDEE----ITDEEDEISDVDDADLMNRLEAKY 532
                ..|.|.|.|:|       ||:. |:..|...||    .:.:.||.||.|.|..:
Zfish   545 AGYLEPDRYDEDEEGEESISLAAIKSKYKGGGGLREERARIYSSDSDEGSDEDKAQRL------- 602

  Fly   533 GRLPVKEFESDPD---------SDDPSWTQIKPKEAAPAPAEKED 568
              :..|..:||.:         .:|......|||:...:..|.||
Zfish   603 --MKAKRLDSDEEGENSGKRKAEEDEESASKKPKKYVISDEEDED 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533
		TPR repeat	684..714	CDD:276809
		TPR repeat	719..748	CDD:276809
		TPR repeat	757..782	CDD:276809
		Asp_Arg_Hydrox	826..977	CDD:282913
leo1	NP_996950.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..336		67/340 (20%)
		PHA02664	<161..260	CDD:177447	11/98 (11%)
		Leo1	352..510	CDD:281933	27/192 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..560		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..696		16/71 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900