DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asph and CG43340

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001246184.1	Gene:	CG43340 / 35698	FlyBaseID:	FBgn0263077	Length:	3213	Species:	Drosophila melanogaster

Alignment Length:	779	Identity:	144/779 - (18%)
Similarity:	248/779 - (31%)	Gaps:	242/779 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 VDEHRDEHDGHDVQEPSGEALDDHDEHDDHDDHEDEEPLTEELEE-------------------- 141
            |:|.:...|.....:.|.:......||..|.:.|..|.:...|:.
  Fly  1454 VEEVKPIEDSTAAIDKSPQISPIEGEHSQHSEKETPESVEVGLDSPNVADVITTSVEVIPTSTTA 1518

  Fly   142 ---------ELEEEEEPTEEDEPAADEEYEEDEDEE-------NNAGENITAEDAEEEEEEE--- 187
                     |:.|..:...|..|.|.||.|::|..|       ....|.|.::|...|..|:
  Fly  1519 VTTSDGASTEMPEPPKIYCETAPPAAEEIEQNETVETLSVSADTTLPEEIVSQDGNLEASEQTAS 1583

  Fly   188 ----------DNDDEGTVEATVEATTEATTEATGE------------------YEAEEDDEDEAA 224
                      :.:.:|.||..|:.......|...|                  .|....:.:||.
  Fly  1584 IDVTFQANLNNMESKGCVEVAVDVRESKEDETLMEPIAVDVAVPVEVVPQCAGVELGVSEPEEAT 1648

  Fly   225 ADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIEESVEPERSQYAAQSAPAKDNNDDDDDDDQDKN 289
            ...:.:.|.|.|..:..|..|.|..:..|:...:|.|.: ||.::.:....::|...::......
  Fly  1649 PATNNLTSGENPPEEVSELVDVEPRNPHEEIHTDSFEKD-SQKSSDAVALHEDNTKSEEKVDPPQ 1712

  Fly   290 DADDGDDD-------------------------------EFESLAQQ------------FENDP- 310
            .|::...|                               |.||:..:            .|:||
  Fly  1713 VAEEVAPDIITLDPPSLVELSPDTQAMAIGNIAPFDIILEPESIVIEQPVPVVKPETIVVESDPE 1777

  Fly   311 --------EDTVPAKAVESEEQDQDQADEEEPKEEGSSWLASLAVKFGV-GVALAL--------V 358
                    |.:|.|:..:..|..|.|..|.:..||.     ||.|..|. |..:::        |
  Fly  1778 AIDHTALLEPSVSAEVQDKVESAQQQVSENKSVEED-----SLKVSIGERGEIISMDPITPADAV 1837

  Fly   359 SRLVLIRKSPNTTEDEPAPETIFRRRLTIA----------TAEDHIPDDVEELPPLDDEYSE--- 410
            |......:.|.|:.:..|.|.|....:...          |.||..|::|.:...::...:|
  Fly  1838 SEQNFRVEDPITSTESTAVEVIASESINTVVEPVSVAQSPTIEDSTPEEVTQCSAVNSTDTEVAS 1902

  Fly   411 -EEIEIEEEI---------EVEISDIEEEEEEVRHDNDDNVASMASYVPETFEQLSAMYKYAQEP 465
             ..|:::::|         ::|.||::|..::......|:|..      ....|:|.......||
  Fly  1903 AAPIQVDQKIQPVHVELVSQIEASDLQESPKDTAQVESDSVDQ------AILTQVSETDSIVVEP 1961

  Fly   466 TKDAKPEQKEKEPEKPVGHSDIY----VEYEDGAIEDY-EHDGVSDEEITDEEDEISDV------ 519
            :...| :.::.:.|.|....::.    ||.:..|.|:. |.|.|:.|.....|:|:.:|
  Fly  1962 SSPVK-QSEDSQGEPPGSAQNVLDVGPVEMDQSAPEEVPETDPVAVEPSVPVEEEVIEVIQPAPK 2025

  Fly   520 DDADLMNRLEAKYGRLPVKEFESDPDSDDPSWTQIKPKEAAPAPAEKEDPFEQELRKANEEMIRE 584
            :.:|.:.|.....|...:                :...|:...|||...| |....:..:|::
  Fly  2026 EISDSVERTLDSLGNTDL----------------VAEAESVDTPAENAGP-EIGTSELEKELL-- 2071

  Fly   585 NYAQALRSFNTLTTNFAHEPSAHLGRARLLELLAKKERSNQRLWEAIDAYKRYLAFGELVASNQE 649
                      .::|....:|||.|   ..|.|:.:.|.:|      :|
  Fly  2072 ----------VVSTTIDEQPSAVL---EPLVLICQAESTN------LD----------------- 2100

  Fly   650 FQTAGESCIENLRFLGHHRQATTIHELLINRLPEDPRLRNQLSLTYLMVNNLQQVEKVAVETLK 713
                 ....|||...|....|:....|.|...|.|  |..|.|:..::     |.|.|..|.:|
  Fly  2101 -----HELPENLVPQGQSVPASLPTNLTIQTQPTD--LETQPSMELIL-----QTETVDAEMVK 2152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	22/104 (21%)
		TPR repeat	684..714	CDD:276809	9/30 (30%)
		TPR repeat	719..748	CDD:276809
		TPR repeat	757..782	CDD:276809
		Asp_Arg_Hydrox	826..977	CDD:282913
CG43340	NP_001246184.1	FYVE_BSN_PCLO	63..119	CDD:277290
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900