DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asph and IBSP

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_004958.2	Gene:	IBSP / 3381	HGNCID:	5341	Length:	317	Species:	Homo sapiens

Alignment Length:	310	Identity:	75/310 - (24%)
Similarity:	116/310 - (37%)	Gaps:	95/310 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 LEEEEEPTEEDEPAADEEYEEDEDEENNAGENITAEDAEEEEEEEDNDDEGTVEATVEATT---- 203
            ::...:.:||:...:.|| ||:|:|.:|.|||     .||..|:||::.|.|   |:.|||
Human    60 VQGSSDSSEENGDDSSEE-EEEEEETSNEGEN-----NEESNEDEDSEAENT---TLSATTLGYG 115

  Fly   204 EATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIEES-VEPERSQY 267
            |..|..|| |......:....|.|...::|     |.:|.:::|:|:||..|.||| .|.:.::
Human   116 EDATPGTG-YTGLAAIQLPKKAGDITNKAT-----KEKESDEEEEEEEEGNENEESEAEVDENE- 173

  Fly   268 AAQSAPAKDNNDDDDDDDQDKNDADDGDDDEFESLAQQFENDPEDTVPAKAVESEEQDQDQADEE 332
              |.......|..:.::....:..|:|:                        |.||:....|:.|
Human   174 --QGINGTSTNSTEAENGNGSSGGDNGE------------------------EGEEESVTGANAE 212

  Fly   333 EPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIATAEDHIPDD 397
            :..|.|         :.|.|.:....        |||...:...|..::|     .|:
Human   213 DTTETG---------RQGKGTSKTTT--------SPNGGFEPTTPPQVYR-----TTS------- 248

  Fly   398 VEELPPLDDEYSEEEIEIEEEIE----------VEISDIEEEEEEVRHDN 437
                ||..   ....:|.|.|.|          .||  .|.|..|.|.||
Human   249 ----PPFG---KTTTVEYEGEYEYTGANEYDNGYEI--YESENGEPRGDN 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533
		TPR repeat	684..714	CDD:276809
		TPR repeat	719..748	CDD:276809
		TPR repeat	757..782	CDD:276809
		Asp_Arg_Hydrox	826..977	CDD:282913
IBSP	NP_004958.2	BSP_II	17..314	CDD:283165	75/310 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..254		63/271 (23%)
		cell-attachment tripeptide	286..288		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900