DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asph and CG34417

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster

Alignment Length:	1281	Identity:	228/1281 - (17%)
Similarity:	409/1281 - (31%)	Gaps:	467/1281 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KDKRRKRDDDESSHGVHITKMGNEDLHLHVHHDHGTGGHWCAKIIFFALMAVLLGLVGLIIMENR 75
            ::|:|:.|...||:||     |..|       ::|                  |.|.|:     |
  Fly  2824 RNKQREEDSITSSYGV-----GPTD-------ENG------------------LPLFGI-----R 2853

  Fly    76 GLEDLDTPLSESRFSKVFDGWVDEHRDEHDGHDVQEPSGEALDDHDEHDDHDDHEDEEPL----T 136
            .|:...||.:|...         |.:.|..|:.::|      ..:.::.....||.:|.:    .
  Fly  2854 ALKKKATPPAEEPC---------ETKQEVTGYVIEE------QFYSDNKSPPRHERKELIYSSNA 2903

  Fly   137 EEL---EEELEEEEEPTEEDEPAAD----EEYEEDEDEE-------------------------- 168
            :||   :::|::|:   :...|..|    .|:::.|.::
  Fly  2904 DELAAIKQQLQDED---DSSPPLLDARVVREFKKVESQQSLPEDARYVRRGSVKELSEKFIRKES 2965

  Fly   169 --------NNAGENITAEDAEEEEEEEDNDDEGTVEATV----EATTEATTEA--TGEYEAEEDD 219
                    ::..:::...:.|.|::.|.||....:||..    ::.|.:||.:  |..:.....|
  Fly  2966 SSSTHSTHSSIAQSLVRHEDETEDDSESNDVCSVIEAPQMRQNQSHTMSTTRSSNTRSFLNSSAD 3030

  Fly   220 EDEAAADDDAVESTEAPLSKAE--EQEDDEDEDEEE--------------QEIEESVEP------ 262
            :.:..:.||.:|.    :..|:  |:..|..||.|.              |.:|..:.|
  Fly  3031 QRQVTSVDDVLER----MRNADNVEEPGDSSEDREARALLNKFLGASVIMQGVESMLPPTATGQR 3091

  Fly   263 ------------------------------ERSQYAAQSAPAKDNNDDDDD--DDQ--------- 286
                                          ..::.::.|||......|.::  |:|
  Fly  3092 LNSQGVKTTRITNTYSKSGNSTSTTNNTSNTTNKVSSSSAPVTRTTCDIEEIWDEQVLKQLLEQA 3156

  Fly   287 ----------------------DKN--DADDGDDDEFESLAQQFE---------NDPEDTVP--- 315
                                  .||  .|...:.:|.||.|.::|         :|.|:.||
  Fly  3157 STYEERRKIRARLRELMAEREEQKNLKQAPKEEKEEEESSASEYEEIIEEVTDYSDEEEEVPPKK 3221

  Fly   316 ------------------------------AKAVESEEQDQDQADEEEPKE-------------- 336
                                          .|.||..|....||.|...|:
  Fly  3222 EEPKKEEVTKKEVTKKEVTTKQQEEIQQKAVKKVEKTETKTSQATESVSKKLAKVELASSSSSST 3286

  Fly   337 ------EGSSWLASLAVKFG-VGVALALVSRLVLIRKSPNTT----------EDEPAPETI---- 380
                  :|.| |.:.|.|.| .|.|..:.|..:..|||.:.:          .|:..||.:
  Fly  3287 TDGVQVQGES-LPAKATKTGATGAAGPVSSSSIGSRKSSSLSSSQVSTVVRARDKAKPEMMPVAG 3350

  Fly   381 ---------------FRRRLTIATAEDHIPDDVEELPPL------------DDEYSEEEIEIEEE 418
                           ...||::.:.||...:..|:|..|            ..:.||....:.||
  Fly  3351 TGSGSESVPGSGAPNTGSRLSVPSKEDSGTESGEDLRLLAAGLRDTLQQQSGSDASEANRSLVEE 3415

  Fly   419 IEVEISDIE---EEEEEVRHDNDDNVASMASYVPETFEQLSAMYKYAQEPTKDAKPEQKEKEPE- 479
            :...:|.:|   ::.:|:..|.....| :...|......|||..|.|:    |.|.::.:||.|
  Fly  3416 VTDALSRLESSLKQGKELAVDGGQRQA-LLGLVARLQSGLSAPEKLAE----DRKTDECQKEVET 3475

  Fly   480 ---KPVGHSDIYVEYEDGAIEDYEHD-GVSDEEITDEEDEISD---VDDADLMNRLEAKYGRLPV 537
               :|.|.|. ...:......:..|. |||.||:.|....:.|   ::..|...........:||
  Fly  3476 GSPEPDGDSR-QSRFAKRRQRNSRHTVGVSREELADARRYMEDMLILEGKDFALSKTPSSSAVPV 3539

  Fly   538 KEFESD---PDSDDPSWTQIKPKEAAPAPAEKEDPFEQELR--KANEEMIRENYAQALRSF--NT 595
            :.:..:   ..|..|.....:|......|.:.    :.:||  .:|...:..:||.:..|:  |.
  Fly  3540 QLYRPNQFVAQSQQPQSVNNQPNATQALPTQN----QSQLRPNTSNRRPLSGDYAVSFASYEANQ 3600

  Fly   596 LTTNFAHEPSAHL-------------------GRARLLELLAKKERSNQRLWEAID---AYKRYL 638
            .:.|.:.|.:.:.                   |:..|:      :|:|     .||   |..:|:
  Fly  3601 NSQNSSPEGNGNSASNSQSNSNSSSNSSRFGGGKKHLM------KRAN-----TIDIPKAKAKYM 3654

  Fly   639 AFGELVASNQEFQTAGESCIENLR--FLGHHRQA-TTIHELLINRLPE-DPRLRNQLSLTYLMVN 699
            |           ....:|.:|:..  .||..|.. .::...:.|.:|. :|:..|....
  Fly  3655 A-----------DCDSDSDLEDDHGPHLGLKRAVQVSVKRRVHNAVPPFEPKTENDHKF------ 3702

  Fly   700 NLQQVEKVAVETLKLWPNNAVAQLHYGLALRQFHADYAKALPYLKYAVESGEEGT---------- 754
             |..:.|.:.:|...|.......:          :::......:|:..|:|...|
  Fly  3703 -LAFINKQSHQTGLGWSGGGGRSV----------SNWTHKFGNIKHTFETGAAATVTKGKPPPVP 3756

  Fly   755 --------QEAFFYLSL-GETMQRLSMKSEALEVYGKGVAKGFFASLYQRSLYNEPRLRAQPFWQ 810
                    ||...:..| .|.|||..|:.|.                |||    |.|.|.|
  Fly  3757 GHVPGWAKQEQLHHQQLQREQMQREQMQREQ----------------YQR----EQRQREQ---- 3797

  Fly   811 PKETGYERQLEKLTLNWRAIRDEGLALLGRSGFFEDEAELLRDKGVWQQYELYAQGRRVKDNCRR 875
             :|...:.|.|:.... ::.||:....|.:...|:.| :|.|::   .|.|...:.:..::..:|
  Fly  3798 -RELREQLQREQYQRE-QSQRDQNQRELSKREQFQRE-QLQREQ---LQREQLQREKLQREQLQR 3856

  Fly   876 APITCSLLE-EFPESAGCRRGQVKFSVMQAKTHVWPHCGPTNCRLRAHLTLAAPEPEKASLRVAE 939
            ..:....|: |..:....:|.|::...:|                |..|.|...:...|::::..
  Fly  3857 EQLQREQLQREQLQREQLQREQLQREQLQ----------------RDQLQLQQQQQAAAAVQIER 3905

  Fly   940 QERTWREGELFIFDDS-FEHEVWHNGSQSRLVLILDMWHPQLSAAQ 984
            |.|...|.:|.:..:: ||.|       .|..|..:.:..||...|
  Fly  3906 QRRQELERQLRLEQEARFERE-------ERTRLEREYYEQQLQRQQ 3944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	51/269 (19%)
		TPR repeat	684..714	CDD:276809	5/29 (17%)
		TPR repeat	719..748	CDD:276809	1/28 (4%)
		TPR repeat	757..782	CDD:276809	7/25 (28%)
		Asp_Arg_Hydrox	826..977	CDD:282913	28/152 (18%)
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290	6/48 (13%)
		GBP_C	<3810..3882	CDD:303769	14/76 (18%)
		coiled coil	3857..3868	CDD:293879	1/10 (10%)
		CH	5076..5179	CDD:237981
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900