Protein Alignment Asph and Asph

DIOPT Version :9

• Sequence 1: NP_001261020.1
• Gene: Asph / 36778
• FlyBaseID: FBgn0034075
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_038965694.1
• Gene: Asph / 312981
• RGDID: 1312000
• Length: 811
• Species: Rattus norvegicus
• Alignment Length: 998
• Identity: 298/998 - (29%)
• Similarity: 443/998 - (44%)
• Gaps: 255/998 - (25%)

  Fly    21 ESSHGVHITKMGNEDLHLHVHHDHGTGGHWCAKIIFFALMAVLLGLVGLIIMENRGLEDLDTPLS 85
            |:.||.|  |.|..            ||........:.::..|||:...:.:....|.|.:..|:
  Rat    42 EAKHGGH--KNGRR------------GGISGGSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLA 92

  Fly    86 ESR-----FSKVFDGWVDEHRDEHDG-HDVQEPS---GEALDDHDEHDDHDDHEDEEPLTEELEE 141
            :::     .|:|..|.:..:..:.|| .||.:..   |...|..:|:.|            .|||
  Rat    93 KAKDFRYNLSEVLQGKLGVYDADGDGDFDVDDAKVLLGLTKDGSNENID------------SLEE 145

  Fly   142 ELEEEEEPTEEDEPAADEEYEEDEDEENNAG------ENITAEDAEEEEEEEDNDD--EGTVEAT 198
            .|      |...|.::|..|          |      :.:|..:..||||||:..|  :|..|
  Rat   146 VL------TILAEESSDWFY----------GFLSFLYDIMTPFEMLEEEEEEETADGVDGLKE-- 192

  Fly   199 VEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIEESVEPE 263
             .:|:|.|.       ..|:.|.:|..::.|.|..||      :..:||.:::.:..::|||..:
  Rat   193 -RSTSERTF-------PPEEAETQAELEEQAPEGAEA------QNVEDEVKEQIQSLLQESVHTD 243

  Fly   264 RSQYAAQSAPAKDNNDDDDDDDQDKNDADDGDDDEFESLAQQFENDPEDTVPAKAVESEEQDQDQ 328
            ....|  ..||    .:...:.:|...|.| .||.||:|      :| .||       .|..:|.
  Rat   244 HDLEA--DGPA----GEPQSEVEDFLTATD-SDDRFEAL------EP-GTV-------HEDTEDS 287

  Fly   329 ADEEEPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIATAEDH 393
            ...||                                                       ||..:
  Rat   288 YHVEE-------------------------------------------------------TASQN 297

  Fly   394 IPDDVEELPPLDDEYSEEEIEIEEEIEVEISDIEEEEEEVRHDNDDNVASMASYVPETFEQLSAM 458
            .|:|.||:      .||:|.....| .|....:::..|||||::.|
  Rat   298 HPNDAEEV------MSEQESSDHGE-AVTDDGLQQHAEEVRHEDYD------------------- 336

  Fly   459 YKYAQEPTKDAKPEQKEKEPEKPVGHSDIYVEYEDGAIEDYEHDGVSDEEITDEEDEISDVDDAD 523
                 ||..:  |.:.|:            :|..|.||:        |..|..||..::.|::
  Rat   337 -----EPVYE--PSENER------------IEISDNAID--------DSNIISEEINVASVEE-- 372

  Fly   524 LMNRLEAKYGRLPVKEFESDPDSDDPSWTQIKPK---------EAAPAPAEKEDPFEQELRKANE 579
                                 ..|.|...:.|||         :|....|||       |||
  Rat   373 ---------------------QQDTPPVKKKKPKLLNKFDKTIKAELDAAEK-------LRK--- 406

  Fly   580 EMIRENYAQALRSFNTLTTNFAHEPSAHLGRARLLELLAKKERSNQRLWEAIDAYKRYLAFGELV 644
               |....:|:.:|..|...:...|.|..|:|:..:.||:|:|||:.|..||:.|:...:..:..
  Rat   407 ---RGKIEEAVSAFEELVRRYPQSPRARYGKAQCEDDLAEKQRSNEVLRRAIETYQEAASLPDAP 468

  Fly   645 ASNQEFQTAGESCIENLRFLGHHRQATTIHELLINRLPEDPRLRNQLSLTYLMVNNLQQVEKVAV 709
            ....:......|  |..:||||.|.:....:.|:...|.|..|:|.|.:.||::.:....:||..
  Rat   469 TDLVKLSLKRRS--ERQQFLGHMRGSLLTLQRLVQLFPSDTTLKNDLGVGYLLMGDNDSAKKVYE 531

  Fly   710 ETLKLWPNNAVAQLHYGLALRQFHADYAKALPYLKYAVESGEEGTQEAFFYLSLGETMQRLSMKS 774
            |.|.:.||:..|::|||..|:..:. .|:::||||..:|||:.||.:..||..||:.|||:..|
  Rat   532 EVLNVTPNDGFAKVHYGFILKAQNR-IAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNK- 594

  Fly   775 EALEVYGKGVAKGFFASLYQRSLYNEPRLRAQPFWQPKETGYERQLEKLTLNWRAIRDEGLALLG 839
            ||.:.|..|..:|.|||::||||||...|:|||:|.|:||||...::.|..||:.||||||.::.
  Rat   595 EAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPRETGYTELVKSLERNWKLIRDEGLMVMD 659

  Fly   840 RS-GFFEDEAELLRDKGVWQQYELYAQGRRVKDNCRRAPITCSLLEEFPESAGCRRGQVKFSVMQ 903
            :: |.|..|.|.||:||.|.|:.|:.|||:.::.|:.||.||:|||:|.|:.||||||:|:|:|.
  Rat   660 KAKGLFLPEDENLREKGDWSQFTLWQQGRKNENACKGAPKTCTLLEKFSETTGCRRGQIKYSIMH 724

  Fly   904 AKTHVWPHCGPTNCRLRAHLTLAAPEPEKASLRVAEQERTWREGELFIFDDSFEHEVWHNGSQSR 968
            ..||||||.||||||||.||.|..|: |...:|.|.:.|:|.||::.|||||||||||.:.|..|
  Rat   725 PGTHVWPHTGPTNCRLRMHLGLVIPK-EGCKIRCANETRSWEEGKVLIFDDSFEHEVWQDASSFR 788

  Fly   969 LVLILDMWHPQLSAAQRRSLSPI 991
            |:.|:|:|||:|:..|||||..|
  Rat   789 LIFIVDVWHPELTPQQRRSLPAI 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	94/244 (39%)
		TPR repeat	684..714	CDD:276809	10/29 (34%)
		TPR repeat	719..748	CDD:276809	10/28 (36%)
		TPR repeat	757..782	CDD:276809	11/24 (46%)
		Asp_Arg_Hydrox	826..977	CDD:282913	82/151 (54%)
Asph	XP_038965694.1	Asp-B-Hydro_N	61..376	CDD:191249	71/331 (21%)
		PEP_TPR_lipo	<394..>580	CDD:274350	35/194 (18%)
		TPR repeat	394..422	CDD:276809	5/27 (19%)
		TPR repeat	427..461	CDD:276809	10/33 (30%)
		TPR repeat	511..535	CDD:276809	7/23 (30%)
		TPR repeat	540..570	CDD:276809	2/29 (7%)
		TPR repeat	578..601	CDD:276809	8/31 (26%)
		Asp_Arg_Hydrox	644..798	CDD:398678	51/153 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350708
Domainoid	1	1.000	190	1.000	Domainoid score	I3193
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2091
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006478
OrthoInspector	1	1.000	-	-		oto97600
orthoMCL	1	0.900	-	-		OOG6_104569
Panther	1	1.100	-	-	LDO	PTHR12366
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4726
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890