DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asph and Dmp1

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_006250684.1	Gene:	Dmp1 / 25312	RGDID:	2508	Length:	504	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	110/533 - (20%)
Similarity:	190/533 - (35%)	Gaps:	118/533 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 EHRDEHDGHDVQEP-------SGEALDDHDEHDDHDDHEDEEPLTEELEEELEEEEEPTEEDEPA 156
            |..:|..|:..|.|       |.|......|...:.||.|.....|||..: ..:..|......:
  Rat    28 ESSEERTGNLAQSPPPPMNSESSEESKVSPEGQANSDHTDSSESGEELGSD-RSQYRPAGGLSKS 91

  Fly   157 ADEEYEEDEDEENNAGENITAED---AEEEEE-------EEDNDDEGTVEATVEATTEATTEATG 211
            |..:.:::|||:::..:....||   ..||.:       :.|.|...|.:::.::|::..:....
  Rat    92 AGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDT 156

  Fly   212 EYEAEEDDEDEAAADDDAVESTEAPLSKAEEQE------------DDEDEDEEEQEIEE--SVEP 262
            ..::::...|||.:..:|.:||:.  |::||..            |..:.|:|..:.::  |...
  Rat   157 PSDSKDHHSDEADSRPEAGDSTQD--SESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRS 219

  Fly   263 ERSQYAAQSAPAKDNNDDDDDDDQDKNDADDGDDDEF---ESLAQQFENDPEDTVPAKAVESEEQ 324
            :|......||..:......|.:.....|:||..|.||   :|..:...::.:|........|.|.
  Rat   220 DRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRET 284

  Fly   325 DQDQADEEEPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIAT 389
            ..|..::...|||..|                            .|.||               |
  Rat   285 QSDSTEDFRSKEESRS----------------------------ETQED---------------T 306

  Fly   390 AEDHIPDDVEELPPLDDEYSEEEIEIEEEIEVEISDIEEEE---EEVRHDNDDNVASMASYVPET 451
            ||....:|..|......|.|||..|..:|     |..|.:|   .|.|.||.||.:       :|
  Rat   307 AETQSQEDSPEGQDPSSESSEEAGEPSQE-----SSSESQEGVASESRGDNPDNTS-------QT 359

  Fly   452 FEQLSAMYKYAQEPTKDAKPEQKEKEPEKPVGHSDIYVEYEDGAIEDYEHDGVSDEEITDEEDEI 516
            .:|            :|:  |..|::.......|:.....|.|..|..|...:|:|.....:||.
  Rat   360 GDQ------------RDS--ESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQDED 410

  Fly   517 SDVDDADLMNRLEAKYGRLPVKEFES--------DPDSDDPSWTQIKPKEAAPAPAEKEDPFEQE 573
            |...:. |.::..::..|....:.|.        |.||.|.|.::.:........:.:||...:.
  Rat   411 SSSQEG-LQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSSSEEDNHPKN 474

  Fly   574 LRKANEEMIRENY 586
            :...|.::|.:.|
  Rat   475 IEADNRKLIVDAY 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533
		TPR repeat	684..714	CDD:276809
		TPR repeat	719..748	CDD:276809
		TPR repeat	757..782	CDD:276809
		Asp_Arg_Hydrox	826..977	CDD:282913
Dmp1	XP_006250684.1	DMP1	1..504	CDD:284637	110/533 (21%)
Dmp1	XP_006250684.1	PHA02664	<112..195	CDD:177447	17/84 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900