DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asph and Rp1

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_035413.1	Gene:	Rp1 / 19888	MGIID:	1341105	Length:	2095	Species:	Mus musculus

Alignment Length:	852	Identity:	144/852 - (16%)
Similarity:	246/852 - (28%)	Gaps:	304/852 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 GEALDD------HDEHDDHDDHEDEEPLTEELE--EELEEEEEPTEEDEPAADEEYEED------ 164
            |..|.|      .|.|..|..|..|...|::||  |||:..::..:.....||..|:.|
Mouse  1296 GACLSDETHIPIRDCHTIHSVHSKENKCTDDLESTEELKTVDKVPKGLSILADSMYKNDSNVSTF 1360

  Fly   165 ---------------------------EDEEN-------NAGENITAEDAEEEEEEEDNDDEGTV 195
                                       |:.:|       |..::|:::..|....||.
Mouse  1361 QNVNKLSSQRTLLSKTYLDSDKDYSPLEEFQNCPRKKIVNKKKSISSDKEESRTSEEP------- 1418

  Fly   196 EATVEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIE--- 257
            .:...:.|.:...|..|.|:.|:.|.:    |.::.:......|...:|..:.:.|.....|
Mouse  1419 RSITNSMTSSERNAISELESFEELESQ----DTSIFNMNVRAEKKSTKETMQKQSEARMSSELIN 1479

  Fly   258 ----ESVEPERSQYAAQSAPAK------------DNNDDDDDDDQD-------KNDADDGDDDEF 299
                :.:|.||...|.....|:            |:|.:.:.:..:       |...|..:::.:
Mouse  1480 VSGRKIIEQERRNTAILETTARGQVTPPSLAFCYDSNKNTEKEISEGETKMRVKKMVDSMENESY 1544

  Fly   300 ESLAQQFE---------------NDPEDTVPAKAVESEEQDQDQADEEEPKEEGSSWLASLAVKF 349
            ...:..|:               :|.|...|.|| .|...:.|...|:||..
Mouse  1545 SESSLNFKKHHRSPGTLDWSDYGSDSESGYPCKA-SSNSHNDDSGQEKEPTR------------- 1595

  Fly   350 GVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIATAEDHIPDDVEELPPLDDEYSEEEIE 414
                  .:|.|.:               |.::.:...|.....|......::.|    |:..|::
Mouse  1596 ------GIVKRAI---------------EKLYGKAEIIKPPFFHGSIHKSQVCP----YNSVEVQ 1635

  Fly   415 IEEE---IEVEISDIEEEEEEVRHDNDDNVASMASYVPETFEQLSAMYKYAQEPTKDAKPEQKEK 476
            ..::   .|.|...:...|:          .|.:|.:.:.|.|:.|      ....|:..:...:
Mouse  1636 CAKKTNFYESECQSLVSSEQ----------VSRSSLIFQEFPQVDA------NGMGDSFGDSSIE 1684

  Fly   477 EPEKPVGHSDIYVEYEDGAIED---------------YEHDGVSDEEITDEEDEISDVDDADLMN 526
            ...|...|..::.|.|:|.:.|               .::.|:.....|...|.:.|      .|
Mouse  1685 NVTKSSAHDRVFTEKENGKLIDNGKWLLRENHLWRVSSDNPGMYGNADTTSVDTLID------KN 1743

  Fly   527 RLEAKYGRLPVKEFESDPDSDDPSWTQIKPKEAAPAP--AEKEDPFEQELRKANEEMIRENYAQA 589
            .:|..|...                     .|.||.|  ||......:|:.:..|  ::.||
Mouse  1744 SIEVPYSHF---------------------GELAPGPTMAELSSSEIEEMTQPLE--VKCNY--- 1782

  Fly   590 LRSFNTLTTNFAH----EPSAHLGRARLLELLAKKERSNQRLWEAIDAYKRYLAFGELVASNQEF 650
                    .||.|    ||                                   |||      :|
Mouse  1783 --------FNFPHGSDSEP-----------------------------------FGE------DF 1798

  Fly   651 QTAGESCIENLRFLGHHRQATTIHELLINRLPEDPRLRNQLSLTYLMVNNLQQVEKVAVETLKLW 715
            ..|........:...||.:....:          |..|...|:|...|:...:|..|..:.:|..
Mouse  1799 PDAQNKTCPKEKIPNHHTEEKGNY----------PSERLCTSVTQAFVSAGNKVHPVCSDAIKTQ 1853

  Fly   716 P----NNAVAQLHYGLALRQFHADYAKALPYLKYAVESGEEGTQEAFFYLSLGETMQRLSM---- 772
            |    |.....|..|.:|.:.:|...:..|.|...::...|.:: .|.|....:....|..
Mouse  1854 PLPGSNITHGALQEGDSLDKLYALCGQHCPILTVIIQPVNEESR-GFAYRKDSDIENSLDFQLWM 1917

  Fly   773 ---------KSEALEVYGKGVAKG-FFA---------SLYQRSLYNEPRLRAQPFWQPKETGYER 818
                     |.......|:.|:.| .||         .||.:|:.:....||      ...|.|.
Mouse  1918 KIYPFMPQSKKHVFRSDGRNVSVGEEFAGNVIGDLCDQLYFKSMIDLVDQRA------NSLGKEI 1976

  Fly   819 QLEKLTL 825
            .|:|..|
Mouse  1977 NLKKFQL 1983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	43/243 (18%)
		TPR repeat	684..714	CDD:276809	7/29 (24%)
		TPR repeat	719..748	CDD:276809	6/28 (21%)
		TPR repeat	757..782	CDD:276809	4/37 (11%)
		Asp_Arg_Hydrox	826..977	CDD:282913	144/852 (17%)
Rp1	NP_035413.1	DCX	35..110	CDD:176357
		DCX	157..232	CDD:176357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..379
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..887
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1400..1430		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1595		8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900