DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asph and DMP1

DIOPT Version :9

Sequence 1:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_011530007.1	Gene:	DMP1 / 1758	HGNCID:	2932	Length:	542	Species:	Homo sapiens

Alignment Length:	531	Identity:	106/531 - (19%)
Similarity:	198/531 - (37%)	Gaps:	133/531 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 EHRDEHDGHDVQEPSGEALDDHDEHDDHDDHEDEEPLTEELEEELEEEEEPTEEDEPAADEEY-- 161
            |..:|..||..|.|:...       :..:..|..:..:||...|...:...:||...:.|.:|
Human    57 EDSEEWKGHLAQAPTPPL-------ESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIY 114

  Fly   162 --------------EEDEDEENNAGENITAED-----AEEEEE--------EEDNDDEGTVEATV 199
                          ::.:|:|:::|::...:|     .::.:|        :||:||  |::|:.
Human   115 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDD--TIQASE 177

  Fly   200 EATTEATTEA--TGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQ-----EDDE---------D 248
            |:..:....|  |.....|.|:||...:..:..:||:.  |::||.     .|.|         |
Human   178 ESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQE--SESEEHWVGGGSDGESSHGDGSELD 240

  Fly   249 EDEEEQEIEESVEPERSQYAAQSAPAKDNNDDDDDDDQDKNDADDGDDDEFESLAQQFENDPEDT 313
            ::..:.:..||:..||......||..|  :.:..::.:..|..|.|        ..|....|...
Human   241 DEGMQSDDPESIRSERGNSRMNSAGMK--SKESGENSEQANTQDSG--------GSQLLEHPSRK 295

  Fly   314 VPAKAVESEEQDQDQADEEEPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPE 378
            :..|:..|||.|:.:.|:....||..|                            ::||:..:.:
Human   296 IFRKSRISEEDDRSELDDNNTMEEVKS----------------------------DSTENSNSRD 332

  Fly   379 TIFR--RRLTIATAEDHIPDDV--EELPPLDDEYSEEEIEIEEEIEVEISDIEEEEEEVRHDNDD 439
            |...  ||.:...:::...:::  ||...:|...||.  ..|..:..:.:..|.:||.|.....|
Human   333 TGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSES--SQEANLSSQENSSESQEEVVSESRGD 395

  Fly   440 NVASMASYV----------PETFEQLSAMYKYAQEPTKDAKPEQ----KEKEPEKPV---GHSDI 487
            |.....|||          .::...||.....::|...|::..:    .|:.||.|.   ..|..
Human   396 NPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQE 460

  Fly   488 YVEYEDGAIEDYEHDGVSDEEITDEED-------------EISDVDDADLMNRLEAKYGRLPVKE 539
            .::....:.|....:..|:|:.:|.:|             :.|..:|..|.| :|.:..:|.|..
Human   461 GLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN-IEIESRKLTVDA 524

  Fly   540 FESDP--DSDD 548
            :.:.|  |.||
Human   525 YHNKPIGDQDD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533
		TPR repeat	684..714	CDD:276809
		TPR repeat	719..748	CDD:276809
		TPR repeat	757..782	CDD:276809
		Asp_Arg_Hydrox	826..977	CDD:282913
DMP1	XP_011530007.1	DMP1	30..542	CDD:284637	106/531 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900