Protein Alignment Asph and LEO1

DIOPT Version :9

• Sequence 1: NP_001261020.1
• Gene: Asph / 36778
• FlyBaseID: FBgn0034075
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001310832.1
• Gene: LEO1 / 123169
• HGNCID: 30401
• Length: 688
• Species: Homo sapiens
• Alignment Length: 792
• Identity: 164/792 - (20%)
• Similarity: 291/792 - (36%)
• Gaps: 208/792 - (26%)

  Fly   108 DVQEPSGEALDDHDEHDDHDDHEDEEPLTEELEEELEEEEEPTEEDEPAADEEYEEDEDEENNAG 172
            |:::..|...|...|..|.|...|.           :.::|.......|:..  |.|:||..::|
Human     3 DMEDLFGSDADSEAERKDSDSGSDS-----------DSDQENAASGSNASGS--ESDQDERGDSG 54

  Fly   173 E----NITAEDAEEE-----------EEEEDNDDEGTVEATVEATTEATTEATGEYEAEEDDEDE 222
            :    .:..:|:|:|           .|..||..|.:..:..|....:..:.....||..|||||
Human    55 QPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE 119

  Fly   223 AAADDDAVESTEAPLSKAEEQED------DEDEDEEEQEIEESVEPERSQYAAQSAPAKDNNDDD 281
            ....|.....:||..|:....:|      |:.:..::::|:.|.:.||:|.:.:.   |..|.||
Human   120 GHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDED---KLQNSDD 181

  Fly   282 DDDDQDKNDAD--DGDDDEFESLAQQFENDPEDTVPAKAVESEEQDQDQADEEEPK---EEGSSW 341
            |:..|:.:|.:  ...|||.:.|:::.:.:.:|..|. |.:::::.|:..|||:|:   ||
Human   182 DEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPV-ASDNDDEKQNSDDEEQPQLSDEE---- 241

  Fly   342 LASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIATAEDHIPDDVEELPPLDD 406
                                    |..|:.::.|.           |:.|:|...|.||    :.
Human   242 ------------------------KMQNSDDERPQ-----------ASDEEHRHSDDEE----EQ 267

  Fly   407 EYSEEEIEIEEEIEVEISDIEEEEEEVRHDN---DDNVASMASYVPETFEQLSAMYKYAQEPTKD 468
            ::..|        ....||.|:|...::..|   .|:.|...:.||:.......::..|.:.:..
Human   268 DHKSE--------SARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSG 324

  Fly   469 AKPEQKEKEPEKPVGHSDIYVEYEDGAIEDYEHDGVSDEEITDEEDEISDVDDADLMNRLEAKYG 533
            :..|.|...|.:||.        |:|..:|.:.:....|  |..|.||..| :.||.|.|  .:.
Human   325 SDGEDKPPTPGQPVD--------ENGLPQDQQEEEPIPE--TRIEVEIPKV-NTDLGNDL--YFV 376

  Fly   534 RLP---------------VKEFESDPDSDDPSWTQIKPKEAAPAPAEKEDPFEQELRKANE-EMI 582
            :||               ..|||.:...|:...|::|.|        .|:.....:|:..| ..|
Human   377 KLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLK--------VENTIRWRIRRDEEGNEI 433

  Fly   583 RENYAQALR-SFNTLTTNFAHEPSAHLGRARLLELLAKKERSNQRLWEAIDAYKR---------Y 637
            :|:.|:.:: |..::        |.|||.                  |..|.||.         :
Human   434 KESNARIVKWSDGSM--------SLHLGN------------------EVFDVYKAPLQGDHNHLF 472

  Fly   638 LAFGELVASNQEFQTAGESCIENLRFLGHHRQATTIHEL---LINRLPEDPRLRNQLSLTYLMVN 699
            :..|..:.....|:|       .|.|..|...:.|..::   |.:|..:..::|     ...|..
Human   473 IRQGTGLQGQAVFKT-------KLTFRPHSTDSATHRKMTLSLADRCSKTQKIR-----ILPMAG 525

  Fly   700 ---NLQQVEKVAVETLKLWPNNAVAQLHYGLALRQFHADYAKALPYL---KYAVESGEEGTQEAF 758
               ..|:.|.:..|..:|  ..::.:......:|:.......:..||   :|..|  |||.:.
Human   526 RDPECQRTEMIKKEEERL--RASIRRESQQRRMREKQHQRGLSASYLEPDRYDEE--EEGEES-- 584

  Fly   759 FYLSLGETMQRL--SMKSEALEVYGKGVAKGFFASLYQRSLYNEPRLRAQPFWQPKETGYERQLE 821
              :||.....|.  .::.|...:|.....:|......||      .|:|:.....:|:| :|:..
Human   585 --ISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQR------LLKAKKLTSDEESG-KRERP 640

  Fly   822 KLTLNWRAIRDE 833
            ||...||..:.|
Human   641 KLKETWRQWKGE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asph	NP_001261020.1	TPR	610..854	CDD:223533	45/244 (18%)
		TPR repeat	684..714	CDD:276809	5/32 (16%)
		TPR repeat	719..748	CDD:276809	4/31 (13%)
		TPR repeat	757..782	CDD:276809	5/26 (19%)
		Asp_Arg_Hydrox	826..977	CDD:282913	3/8 (38%)
LEO1	NP_001310832.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..357		90/431 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..583		8/37 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900