DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rho1 and RHOH

DIOPT Version :9

Sequence 1:	NP_477098.1	Gene:	Rho1 / 36775	FlyBaseID:	FBgn0014020	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_001265288.1	Gene:	RHOH / 399	HGNCID:	686	Length:	191	Species:	Homo sapiens

Alignment Length:	184	Identity:	77/184 - (41%)
Similarity:	110/184 - (59%)	Gaps:	7/184 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRP 71
            |.|:|||.|.|||.||:.|:.:.|||.|.|||:||...|:.:||.|:.|.||||||.:.:..:||
Human     6 KCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIRP 70

  Fly    72 LSYPDTDVILMCFSVDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDPNTIRDLAKMKQ 136
            |||...||:|||:||.:.:|..|:..||..|::...|..|:::|..:.|.       |::...:.
Human    71 LSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQ-------REMGPHRA 128

  Fly   137 EPVKPQEGRAMAEKINAFAYLECSAKSKEGVRDVFETATRAALQVKKRKKTRCL 190
            ..|...||:.:|:.:.|..||||||.|..||:.|||.|.|.|:...:|:..|.|
Human   129 SCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRL 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rho1	NP_477098.1	RhoA_like	5..179	CDD:206662	73/171 (43%)
RHOH	NP_001265288.1	Rho	5..169	CDD:206641	72/169 (43%)
		Effector region. /evidence=ECO:0000250	33..41		5/7 (71%)
		Interaction with ZAP70. /evidence=ECO:0000250	73..86		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810