DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rho1 and RHOBTB2

DIOPT Version :9

Sequence 1:	NP_477098.1	Gene:	Rho1 / 36775	FlyBaseID:	FBgn0014020	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_001153508.1	Gene:	RHOBTB2 / 23221	HGNCID:	18756	Length:	749	Species:	Homo sapiens

Alignment Length:	196	Identity:	73/196 - (37%)
Similarity:	107/196 - (54%)	Gaps:	26/196 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLVIVGDGACGKTCLL------IVFSKDQFPEVYVPTVF--ENYVADIE--------VDGKQVEL 55
            |.|:|||.|.|||.|:      ...::.|....:||||:  :.|....|        ||...|.|
Human    38 KCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSL 102

  Fly    56 ALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 120
            .||||.|  |:.:.|..:|..:||:::|||:.:|:||.::...|.||:|||||..|:||||.:.|
Human   103 RLWDTFG--DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVGCQLD 165

  Fly   121 LR-NDPNTIRDLAKMKQEPVKPQE------GRAMAEKINAFAYLECSAKSKEGVRDVFETATRAA 178
            || .|...:....:....|:||.|      ||.:|::: ...|.|.|..::.|::|||:.|.|||
Human   166 LRYADLEAVNRARRPLARPIKPNEILPPEKGREVAKEL-GIPYYETSVVAQFGIKDVFDNAIRAA 229

  Fly   179 L 179
            |
Human   230 L 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rho1	NP_477098.1	RhoA_like	5..179	CDD:206662	71/194 (37%)
RHOBTB2	NP_001153508.1	RhoBTB	35..229	CDD:133275	70/193 (36%)
		RHO	39..230	CDD:197554	70/193 (36%)
		BTB	280..>327	CDD:295341
		BTB	<443..492	CDD:197585
		BTB	<443..490	CDD:295341
		BTB	513..615	CDD:279045
		BTB	523..615	CDD:197585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810