Protein Alignment CG8414 and GRC3

DIOPT Version :10

• Sequence 1: NP_611084.2
• Gene: CG8414 / 36774
• FlyBaseID: FBgn0034073
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: NP_013065.1
• Gene: GRC3 / 850624
• SGDID: S000003958
• Length: 632
• Species: Saccharomyces cerevisiae
• Alignment Length: 608
• Identity: 133/608 - (21%)
• Similarity: 241/608 - (39%)
• Gaps: 110/608 - (18%)

  Fly   377 LIIEEIFDDPPVEKKQERIEQSSVMDIVVKNLSSVPPKKESEVAIETEENDEVSLPEVVTPEKEN 441
            ::|:...|.|...|.......|...:..:....|:|..|.:.|.:.:||.::         ::.:
Yeast     1 MVIDSKQDLPQYTKDSGSESDSDSSNNFIVESPSIPSSKSATVVLNSEEYED---------DEGD 56

  Fly   442 YLQPSDVPFYRNPQANPTELSVFENSLKSNHVLAVIKEDLEVYGTLVLTLLCGQISVNG--YRAR 504
            .|...|.....|......|.......||.       |:.|.:.|...|.::.|.|..|.  |.|.
Yeast    57 DLNGLDAELIDNITYEGDEDETMFVGLKE-------KQKLHLSGVFRLQVVKGGIVYNNVHYNAS 114

  Fly   505 RQEAITIYSPKGLNWVSISPTKTKKPVKDEVNWEELNKNFTRAQLDRIKTSFQR-QTNAIVLLHR 568
            | |.:|.:.|       :|.:...........|::   .|...:.:|.|...:. ::...||...
Yeast   115 R-EILTFWHP-------LSQSIPTIDFSHFAGWQD---TFFMPRNNRFKIRDEEFKSFPCVLRVF 168

  Fly   569 NTSAQQLVDTFGKHMAQNVFPLVNSSNRPFGQSETLLHCLIQSSDQSRTLQVPQVWN----KLQM 629
            |::...|::  ..|:.::|..|.......|..:|...:.|:..||:.::|.||..|:    ||.:
Yeast   169 NSNHTGLLE--AGHLYRDVNYLWKPKEPYFPLNERTTYHLLHESDRIQSLSVPGYWSTPLEKLYL 231

  Fly   630 -HAT----SRIIVAGGKGVGKSSLLRYLINR-------NLGQFPSMLLIDLDIGQPEIFVPQTIS 682
             |..    :||:|.|||..|||:.||.|:.:       :......::.:|||.||||..:|.:||
Yeast   232 SHKNAAYDTRIMVIGGKNSGKSTFLRLLLEKFTQDIRDSTTSQEELVYLDLDPGQPEYSLPDSIS 296

  Fly   683 CT-VIDEPL-LGPGFLY--NRQPEHAIVVGH-------TNIVLCAEQYARAVIQLVQNIQNDAKY 736
            .. ::..|: ||.....  |.|.......|.       |:.:.||:       :|:.:::..|.:
Yeast   297 LNKILSSPISLGQHLCQGSNFQTLLQFYAGSSSPQDEPTSYLNCAD-------KLIDHLEEQAFF 354

  Fly   737 SNIPWLINTMGYNKGFGIELMALLVDRIRPTDLVQIASPIPINNFDSVLDRNSLSQIKPIIYSAE 801
            ...  |:|..|:.||||::::..::.:.:||.|:.:.:.....:.|.:....|.|......|:.|
Yeast   355 GTS--LLNLPGWIKGFGMQILNHIIRKYKPTHLLFLETANSKRHLDELTIPQSFSTSLRDAYAPE 417

  Fly   802 EFKINEIPKYTL-HKLISAVPAREKGTWSLSAK-------DMRYSNLLARLSSCLT-GNAKS--- 854
               :..:|.::| |.|.|...|.:..|:.:.|.       |..::.||......:: |..||
Yeast   418 ---VVRVPAHSLNHTLSSRFHASQLRTFKILALFHKITQFDYDFAPLLKSAPLQISYGKGKSGIK 479

  Fly   855 -------LTDCQPLGV--SLESLKILHPTSKNYSREELIRGMEANVVYLCHHGAGLPQC------ 904
                   ..|..|..:  :||...|...|   ||.|:.:.....|...:      |..|
Yeast   480 GIQFPMEFQDLNPQDIKSALEGTVIGIYT---YSGEDSLEVKSLNTFPI------LQSCTSSSKN 535

  Fly   905 -LGIGVVRAIDYERK--ELYLVP 924
             :.:|::.:||..::  .:|:.|
Yeast   536 FITLGLIHSIDTSQQIMNIYVPP 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8414	NP_611084.2	MSCRAMM_ClfA	<29..354	CDD:468110
		HC2	30..>163	CDD:369339
		P-loop containing Nucleoside Triphosphate Hydrolases	639..824	CDD:476819	51/203 (25%)
GRC3	NP_013065.1	CLP1_P	246..449	CDD:406878	53/214 (25%)