DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8414 and Nol9

DIOPT Version :9

Sequence 1:	NP_611084.2	Gene:	CG8414 / 36774	FlyBaseID:	FBgn0034073	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_038967289.1	Gene:	Nol9 / 313744	RGDID:	1566167	Length:	715	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	141/598 - (23%)
Similarity:	258/598 - (43%)	Gaps:	111/598 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 NPQANPTE--------LSVFEN------SLKSNHVLAVIK--EDLEVYGTLVLTLLCGQISVNGY 501
            ||:.:.|.        |.|..|      .|.|..||.::.  |.....|...:|.:.||:.:.|:
  Rat   109 NPRNHSTPQSRAGRRVLKVSPNITQPTLDLGSGRVLLMLPPGEGFTFSGICRVTCIYGQLEIYGH 173

  Fly   502 RARR----QEAITIYSPKGL--NWVSIS-PTKTKKPVKDEVNWEELNKNFTRAQ----------- 548
            ..::    |:..::|:...|  |.|..| |.|:||.::.|:  ..|.|.:.:..
  Rat   174 IIKQGQPPQDVFSVYTHSYLTINGVPYSEPEKSKKGIRREI--RALLKPYMKLDDRNWVVRYFPP 236

  Fly   549 ------LDRIKT---SFQR--QTNAIVLLHRNTSAQQLVDTFGKHMAQNVFPLVNSSNRPFGQSE 602
                  |:|::|   .|.|  :..:.|||..|.    ||....:.:|.|... :....|..|
  Rat   237 LGSILILERLQTRLVDFLRTYKCASYVLLQENI----LVRDNSEFVALNKIG-IRRQKRKKG--- 293

  Fly   603 TLLHCLIQSSDQSRTLQVPQVWNKLQMHATSRIIVAGGKGVGKSSLLRYLINRNLGQFPSMLLID 667
               .||    .:|....:.::.:...:.....|::.|...:|||:..|.|||..|...|.:..::
  Rat   294 ---ICL----SESGLCALEELISVSCVDGCPVILLCGACDIGKSTFSRILINHLLNSIPGVDYLE 351

  Fly   668 LDIGQPEIFVPQTISCTVIDEPLLGPGFLYNRQPEHAIVVGHTNIVLCAEQYARAVIQLVQNIQN 732
            .|:||.|...|..||...|.||||||.:.:.|:|:..:..|.||   |..:|.. .|::|:.:..
  Rat   352 CDLGQTEFTPPGCISLLNITEPLLGPPYTHQRKPQKMVYFGKTN---CHNEYEN-YIEIVKYVFR 412

  Fly   733 DAKYSNIPWLINTMGYNKGFGIELMALLVDRIRPTDLVQIAS----PI-PINN-----FDSVLDR 787
            |.| ...|.:|||||:..|.|:.|:..|:..:.|..:||:.|    |: |:.:     .|.:..:
  Rat   413 DYK-REFPLIINTMGWVSGDGLLLLVDLIRVLSPNYVVQLTSDRSEPMQPLTSEFVELTDGLYTK 476

  Fly   788 NSLSQIK---------PIIYSAEEFKINEIPKYTLH-------KLISAVPAREKGTWSLSAKDMR 836
            :.:.:.:         .:.::.||.:.:.:|.:|.|       :.:|:...:.:|.::...:|:.
  Rat   477 SKIKRYRGFEIPEFGDSLGFAEEEKESSPVPVFTGHILLTVYSEFLSSKNEKNRGKYNRIFRDLA 541

  Fly   837 YSNLLARLSSCLTGNAKSLTDCQPLGVSLESLKILHPTSKNYSREELIRGMEANVVYLCH----- 896
            ....|::|...:|.....|....|..|...::.| ..|..:.:...::..|.|:.|.||.
  Rat   542 VLGYLSQLMLPVTEPLCPLHSLTPYQVPFNAVAI-RVTHADVAPTHILYAMNASWVGLCKIVDDM 605

  Fly   897 --HGAG--------LPQCLGIGVVRAIDYERKELYLVPAMPLQKMSLVDCLILGGEQSLPQGFLR 951
              :..|        :..|||.|:.|.||.:::..:::..:|.:::..|:||:: |..|:|....:
  Rat   606 KGYTRGPILLAQNPICDCLGFGICRGIDMDKRLYHILTPLPPEELRTVNCLLV-GTISIPHCIFK 669

  Fly   952 DQGQGVSSSVPFV 964
            :| .|...:||:|
  Rat   670 NQ-PGTEGTVPYV 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8414	NP_611084.2	HC2	41..>163	CDD:284736
		RNA_pol_3_Rpc31	<255..333	CDD:288542
		P-loop_NTPase	639..824	CDD:304359	58/210 (28%)
Nol9	XP_038967289.1	CLP1_P	323..483	CDD:406878	52/164 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353430
Domainoid	1	1.000	81	1.000	Domainoid score	I8369
eggNOG	1	0.900	-	-		E1_COG1341
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005089
OrthoInspector	1	1.000	-	-		oto96887
orthoMCL	1	0.900	-	-		OOG6_103124
Panther	1	1.100	-	-	LDO	PTHR12755
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3611
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.700