DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8414 and SPCC830.03

DIOPT Version :9

Sequence 1:	NP_611084.2	Gene:	CG8414 / 36774	FlyBaseID:	FBgn0034073	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_588473.1	Gene:	SPCC830.03 / 2539329	PomBaseID:	SPCC830.03	Length:	736	Species:	Schizosaccharomyces pombe

Alignment Length:	824	Identity:	176/824 - (21%)
Similarity:	307/824 - (37%)	Gaps:	261/824 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 VRKIKVFKSAQEETDSDEDDIDYEPEDSDDFGSEEFDSEESDSEDTSSADYDSDGDFYSEYSDME 332
            ||::.:.|:|:::.:|.              |.:...||| :|:|....:..::|:|.|
pombe    19 VRQLTLSKAARKKDNSS--------------GKKRSVSEE-ESQDKYEDEMKTEGEFPS------ 62

  Fly   333 DVSDSDSEEFGSDIFDTDDLDSTYEPPDIEGFFDHPPVGMQREPLIIEEIFDDPPVEKKQERIEQ 397
                                            :.|         .:::.:.  |.|:.:.:...:
pombe    63 --------------------------------YKH---------TLVQVVV--PGVDHRTKLHSE 84

  Fly   398 SSVMDIVVK---NLSSVPPKKESEVAIETEENDEVSLPEVVTPE--KENYLQPSDVPFYRNPQAN 457
            ||..|..:.   |.|.|.|::.||.::.:.:....|||..:..|  .||      ||  .:||::
pombe    85 SSKNDSEITPDINRSKVNPQEYSEFSVASPQTISPSLPLNLDDETVSEN------VP--HSPQSS 141

  Fly   458 PTELSVF----ENSLKSNHVLAV-IKED--LEVYGTLVLTLLCGQISVNGYRARRQEAITIYSPK 515
            ...:.|.    |||.:....|.| :.:|  |.:.||.:...:.|:..:.|         ..||..
pombe   142 NDAIPVIKITEENSFRVKDTLYVGLHKDQKLAMVGTFIFRSVRGKFQLFG---------ATYSSA 197

  Fly   516 GLNWVSI-SPTKTKKPVKDEVN----------WEE--LN-KNFTRAQLDRIKTSFQRQT------ 560
            .::|..: :|.....||...::          :||  || ::|........:..::.:.
pombe   198 CMSWFPLNAPLAFATPVFSAIDNALPAMQISEYEEDSLNLRSFAVPSYSPKEHEYELEPKDILPN 262

  Fly   561 -NAIVLLHRNTSAQQLVDTFGKHMAQNVFPLVNSSNRPFGQSETLLHCLIQSSDQSRTLQV-PQV 623
             ..::....|.:        |......|.|.   :.|.|    :..:.|..:|..|...:: |:.
pombe   263 FETVIAFRENEN--------GLSKIARVLPF---AKRLF----SFKNLLQDASSISNNFEITPES 312

  Fly   624 W----NKLQMHATS-------RIIVAGGKGVGKSSLLRYLINRNLGQFPSMLLIDLDIGQPEIFV 677
            |    |:| :.:||       |::|.|.||.||||..||:.||.|.|:..:..:|||.||||:..
pombe   313 WCSFSNQL-LFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPGQPEVVP 376

  Fly   678 PQTISCTVIDEPLLGPGF---LY--------------NRQPEHAIVVGHTNIVLCAEQYARAVIQ 725
            ...||...|:.||.||.|   |:              .:.|:|.|.        |..:.......
pombe   377 SGHISLYYINSPLQGPVFARMLFPTYMLRLHLGDISPQKDPDHYIA--------CVTRLFAEYKD 433

  Fly   726 LVQNIQNDAKYSNIPWLINTMGYNKGFGIELMALLVDRIRPTDLVQIASPIPINNFDSVLDRNSL 790
            .:.| |..::...||.:||..|:.:|.|.||::.:||..:||::|.::..          |..|.
pombe   434 YIFN-QEISQKEIIPLIINCPGWIRGGGAELLSSIVDICQPTEVVYMSRE----------DMKSS 487

  Fly   791 SQIKPIIYSAEEFK---INEIPKYTLHKLISAVPAREKGTW---------SLSAKDMRYSNLLAR 843
            .:.|..||..:|:.   ::...::.|..|        :.||         .:::.|.|...||:.
pombe   488 HREKKSIYQHKEYMPDFLSSRDEFQLTLL--------ESTWQYLPDPNVNKVTSADNRMLGLLSY 544

  Fly   844 L-SSCLTGNAK------SLTDCQPLGVSLESLKILHPTSKNYSREELIRGMEANV---------- 891
            | .:|   |.:      |||.|||:..:.:.      :||......:| |...||
pombe   545 LYFNC---NLQRWDFTTSLTACQPIATAFKG------SSKGIDAVNII-GEPLNVNDVAKTINGT 599

  Fly   892 ---VYLCHHGA----------------------GLP------QCLGIGVVRAIDYERKELYLVPA 925
               :|.|...:                      |||      .|||:.|:|.||.:|.|.:.|..
pombe   600 LMALYACDTASLDNSNTQRIVSSPEGIPLIINDGLPLDPNTSHCLGLIVLRTIDLKRNEFHFVGP 664

  Fly   926 MPLQKM-----SLVDCLILGGEQSLPQGFLRDQGQGVSSSVPFV 964
            :.|:.:     ..:..::..|...||...:.|......|.:|::
pombe   665 LNLELIKDAYAKSLKIVLERGRLELPVYAMLDHRLAQYSELPYL 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8414	NP_611084.2	HC2	41..>163	CDD:284736
		RNA_pol_3_Rpc31	<255..333	CDD:288542	14/64 (22%)
		P-loop_NTPase	639..824	CDD:304359	57/204 (28%)
SPCC830.03	NP_588473.1	Grc3	245..713	CDD:224260	117/517 (23%)
SPCC830.03	NP_588473.1	CLP1_P	338..>483	CDD:293183	49/163 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2710
eggNOG	1	0.900	-	-		E1_COG1341
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005089
OrthoInspector	1	1.000	-	-		oto101158
orthoMCL	1	0.900	-	-		OOG6_103124
Panther	1	1.100	-	-	LDO	PTHR12755
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R523
SonicParanoid	1	1.000	-	-		X3611
TreeFam	1	0.960	-	-
	11	10.800