Protein Alignment CG8414 and LOC1274845

DIOPT Version :10

• Sequence 1: NP_611084.2
• Gene: CG8414 / 36774
• FlyBaseID: FBgn0034073
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: XP_314054.4
• Gene: LOC1274845 / 1274845
• VectorBaseID: AGAMI1_012224
• Length: 1064
• Species: Anopheles gambiae
• Alignment Length: 1115
• Identity: 288/1115 - (25%)
• Similarity: 480/1115 - (43%)
• Gaps: 233/1115 - (20%)

  Fly    21 ELASGRRKPEKPQHPPAVPKKKVISKVASNPAKISETMIQKAQMESPKKSKKNKTAGAKRPLSNN 85
            ::.:|.||          |.|:..:..|....::....::.|.|||.||..|:....:|....|.
Mosquito    25 DVKTGMRK----------PAKEATNSKAKTVYQMQGVKVESATMESKKKQDKDACLASKYTPVNG 79

  Fly    86 VSNPDSSPSQKRLKK----DNTLPKKNPVNKSSNVAAKKS---AATSKSAKLPIPKVHSINELAP 143
            .||.:::.:::..|:    :....||....:::||..:.|   :|:..|||    :..::::.:|
Mosquito    80 NSNANNAAAEENGKETARAEKKRSKKRAKKRNANVMDEDSLGGSASDVSAK----RDPTVDDGSP 140

  Fly   144 KKTKVK-------TPNKTKEASLS--------KKHKV----NGNKSSMKVVQN-GK--------- 179
            .|...|       |.|...:.|.|        ||:.|    :|.|.:.|...: ||
Mosquito   141 AKRSRKLDSDSSDTRNNNGKCSKSPIANDSSKKKNIVGKVASGAKVNPKAAHSAGKPSGEDPVPH 205

  Fly   180 ---VVEIIGTA-AETSDIEMNSLDDWSEEDDYLIESDSENDVVEEIDETFLKDPKIFKVKCKGPE 240
               |::.:|.. ..|||...:     |:||||:.:...|....:|     .|..:..|.|.:..:
Mosquito   206 KVPVLQCVGMEDGATSDSNTD-----SDEDDYIEQFFDEQPEAKE-----KKGSQSNKPKKRAKK 260

  Fly   241 YKLSDILP---PFEHD----EYQPLLLDGDGSG---------TVRKIKVFKSAQ-----EETDSD 284
            ....::.|   ..|::    ||.| ..|.:.:|         :.:|:..||..:     :|.|.|
Mosquito   261 ATAQNVSPGGWVVENNDCSLEYGP-SSDEEPTGKPSASRATESPKKVVAFKRKEPPAEAQEIDED 324

  Fly   285 EDDIDYEPEDSDDFGSEEFDSEESDSEDTSSADYDSDGDFYSEYSDMEDVSD--------SDSEE 341
            :||      |.||:  :.|||||.||:.|...:.....:||....||.:.|:        .||:.
Mosquito   325 DDD------DDDDY--DTFDSEEDDSDWTDDDEDPEVTEFYDNIYDMSNESEYDDYLQKGYDSDS 381

  Fly   342 F-----GSDIFD---------------------------TDDLDSTYEPPDIEGFFDHPPVGMQR 374
            |     |:|.:|                           ||..|..||||  ||   ...|.:.|
Mosquito   382 FDGNMNGADSYDDDYESSADECRSPRNSYSRFTSGQPYETDSDDEDYEPP--EG---DDTVYIPR 441

  Fly   375 EPLIIEEIFDDPPV--------------------EKKQERIEQSSVMDIVVKNLSSVPPKKESEV 419
            ...::.::.||..|                    ||:...::||.      |.......:|...|
Mosquito   442 GAAVLRDLDDDSIVHFDASGKYAQIVELPADYGMEKEGSDLDQSD------KQGEKQEERKSENV 500

  Fly   420 AIETEE--NDEVSLPEVVTPEKENYLQPSDVPFYRNPQANPTELSVFENSLKSNHVLAVIKEDLE 482
            ..|..|  :||.......:|..|...:|:...||              :::.....|.|:|..|.
Mosquito   501 VQEEAEAVDDEAESDRSCSPLLEISPKPTTYTFY--------------DAVDLRMSLVVLKAPLY 551

  Fly   483 VYGTLVLTLLCGQISVNGYRARRQEAITIYSPKGLNWVSISP---TKTKKPVKDEVNWEELNKNF 544
            ::|.|.:..|.|::.:.||:....|..|:::..|.|.::::|   ..|......|....:|:::|
Mosquito   552 IHGHLSVQALFGKVDIFGYQLDMAEKRTVFASGGYNALNLTPLPSPDTYSTATFERILNKLSRHF 616

  Fly   545 TRAQLDRIKTSFQRQTNAIVLLHRNT-SAQQLVDTFGKHMAQ-NVFP---LVNSSNRPFGQSETL 604
            ..|.:..:...|....:|:|||..:: .|...|....:.:.: ::||   .:|.::.||..:|||
Mosquito   617 VEADMRELVREFNPADSALVLLRADSFDANDTVPMVCRLLPEFDLFPTALTLNQTSSPFRTTETL 681

  Fly   605 LH--CLIQSSDQSRTLQVPQ-----VWNKLQMHATSRIIVAGGKGVGKSSLLRYLINRNLGQFPS 662
            |.  ..:.|...:|: .|||     ||:.:.:.|.||::|.|||..|||:|.:|||||.:.||..
Mosquito   682 LEVAMFVPSQPTARS-AVPQFQPNPVWDTVPVSANSRLMVVGGKSSGKSTLCQYLINRYIKQFGR 745

  Fly   663 MLLIDLDIGQPEIFVPQTISCTVIDEPLLGPGFLYNRQPEHAIVVGHTNIVLCAEQYARAVIQLV 727
            :||:|||||||.:|||:|:|.:|::||:||.|...|.||....:.|..|:|.....|.:.|..||
Mosquito   746 VLLLDLDIGQPLLFVPETLSVSVLEEPILGVGCFANAQPRQCKLFGSLNVVSSPLVYVQNVRSLV 810

  Fly   728 QNIQNDAKYSNIPWLINTMGYNKGFGIELMALLVDRIRPTDLVQIASPIPINNFDSVLDRNSLSQ 792
            |....|....:|||:||||||..|||.||...:|..::||||:|::  .|.|.     .::|...
Mosquito   811 QYCNEDPALQDIPWIINTMGYVVGFGEELTMAIVRLLQPTDLIQLS--FPKNG-----KKSSTPF 868

  Fly   793 IKPIIYS----------------AEEFKINEIP-KYTLHKLISAVPAREKGTWSLSAKDMRYSNL 840
            :||..|:                .||.::...| .|..|. |..|  .|....|......|...:
Mosquito   869 LKPENYANQLTAELVNGFNFNILREEVQLQSAPANYRFHP-IDVV--YEPNKTSFLPPKRRTIAM 930

  Fly   841 LARLSSCLTGNAKSLTDCQPLGVSLESLKILHPTSKNYSREELIRGMEANVVYLCHH-GAGLPQC 904
            :|:|:..|:..|::.||.:|....|:.|.|:.......|:|.:.|.:...:||||.. .|....|
Mosquito   931 MAQLARILSDTAETFTDVKPHMAHLDDLSIISTGEDCTSKEMMKRALNGTLVYLCEKLAADQYNC 995

  Fly   905 LGIGVVRAIDYERKELYLVPAMPLQKMSLVDCLILGGEQSLPQGFLRDQGQGVSSSVPFVFILDD 969
            .|:|:||::|.:...:||:.::..::::..:.|.: |..|||..........:..::|::
Mosquito   996 FGVGIVRSVDEKENNVYLLHSLSSEQLAKTNVLAM-GSTSLPSQVYLHCSPKIEGTIPYL----- 1054

  Fly   970 SKSSKSIQQI 979
              .:.||.|:
Mosquito  1055 --QNMSIVQV 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8414	NP_611084.2	MSCRAMM_ClfA	<29..354	CDD:468110	93/425 (22%)
		HC2	30..>163	CDD:369339	32/154 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	639..824	CDD:476819	79/201 (39%)
LOC1274845	XP_314054.4	None