DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8414 and nol9

DIOPT Version :9

Sequence 1:	NP_611084.2	Gene:	CG8414 / 36774	FlyBaseID:	FBgn0034073	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_002933893.2	Gene:	nol9 / 100145740	XenbaseID:	XB-GENE-984093	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	607	Identity:	148/607 - (24%)
Similarity:	261/607 - (42%)	Gaps:	122/607 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 KSNHVLAVIKED------------LEVYGTLVLTLLCGQISVNGYR-ARRQEAITIYSPKGLNWV 520
            |...:.||:.||            |...|...||.|.|.:.|.|.. .:.|:|..::||...:.:
Frog    59 KPQGLTAVLDEDGVCVVLLEPGQKLTFTGKCSLTCLHGSVQVFGLTIIKNQKAYDLFSPHTHSCL 123

  Fly   521 SISPTKTKKPV--KDEVNWE---------------ELNKNFTRAQ----LDRIKTSFQRQTNAIV 564
            ||...|.|||:  |.||..|               .:.|:||.:.    |:|::.|    |.:.:
Frog   124 SIEGLKYKKPLKTKKEVRMEVRALLRGYLSIEYRRTVMKSFTSSSSVILLERLEDS----TTSFI 184

  Fly   565 LLHRNTSAQQLVDTFGKHMAQNVFPL-VNSSNRPFGQSETLLHCLIQSSDQSRTLQVPQVW-NKL 627
            |.|.:.:              |||.. |...|..|..:..|....:::.|.....::.:.| :::
Frog   185 LSHPDYA--------------NVFSTKVKERNSSFTNNAVLYSVGVENRDPENGFKMSEEWHSEV 235

  Fly   628 QM---------HATSRIIVAGGKGVGKSSLLRYLINRNLGQFPSMLLIDLDIGQPEIFVPQTISC 683
            |.         :....|:|.|.|.||||:.:|||:|:.|....|:..:|.|:||.|...|..||.
Frog   236 QTLVNACLEEDNGCPIILVCGSKNVGKSTFIRYLMNQLLNHISSVGYLDCDLGQTEFTPPGCISL 300

  Fly   684 TVIDEPLLGPGFLYNRQPEHAIVVGHTNIVLCAEQYARAVIQLVQNIQNDAKYSNIPWLINTMGY 748
            ..|.||:|||.|.:.::.:..:..|.|:.....|::..:|..::.:.:.|.     |.||||||:
Frog   301 LSITEPVLGPPFTHQQEAQKMVYFGETSCEQDMERFVESVKYVITSYKRDE-----PLLINTMGW 360

  Fly   749 NKGFGIELMALLVDRIRPTDLVQI-------ASPIP---INNFDSVLDR-NSLSQIKPIIY-SAE 801
            .||||:.|:..::..:.|:.::||       ..|:.   :.|....|.: ||.::.|...: |:|
Frog   361 VKGFGLLLLIDIIRLLSPSHIIQINAKDSDDMEPLTQNYVQNAPGFLTKGNSTARRKAREFDSSE 425

  Fly   802 EFKINEIPKYTL------HKLISA----VPAREKGT---WSLSAKDMRYSNLLARLSSCLTGNAK 853
            :.::.:..:|..      |:|::.    :.|.|.|.   .|...:|:.....|::|.........
Frog   426 DEQLQDSSEYLCFHSHPGHQLVALEADFIGAGEAGNVRCHSGILRDLAMLGYLSKLQHFHPEKVI 490

  Fly   854 SLTDCQPLGVSLE--SLKILHPTSKNYSREELIRGMEANVVYLC------HHGAGLP-------- 902
            .:....|..|...  ::::.|   .:.:...::..:.|:.|.||      |.....|
Frog   491 PINSLIPYEVPFNAVAVRVAH---SDVAPSHIMYSVNASWVGLCRILDDIHSDNDGPVILTQTPI 552

  Fly   903 -QCLGIGVVRAIDYERKELY-LVPAMPLQKMSLVDCLILGGEQSLPQGFLRDQGQGVSSSVPFV- 964
             .|||.|:||.::.|:|..| |.|.:| :.:.:|:||:: |..|:|....::| .|....:|:|
Frog   553 CDCLGFGIVRGVNMEKKVYYVLTPLLP-ESLRVVNCLLV-GNISIPHAIFKNQ-PGAKGEIPYVT 614

  Fly   965 ----FILDDSKSSKSIQQIYHR 982
                |.:..:...|..:|:..|
Frog   615 SEYDFTVSGAGKMKRNKQLKRR 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8414	NP_611084.2	HC2	41..>163	CDD:284736
		RNA_pol_3_Rpc31	<255..333	CDD:288542
		P-loop_NTPase	639..824	CDD:304359	59/206 (29%)
nol9	XP_002933893.2	CLP1_P	256..>382	CDD:379861	45/130 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7754
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005089
OrthoInspector	1	1.000	-	-		oto103581
Panther	1	1.100	-	-	LDO	PTHR12755
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010