DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dg and dag1

DIOPT Version :9

Sequence 1:	NP_788363.1	Gene:	Dg / 36773	FlyBaseID:	FBgn0034072	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_775381.1	Gene:	dag1 / 286829	ZFINID:	ZDB-GENE-021223-1	Length:	866	Species:	Danio rerio

Alignment Length:	810	Identity:	187/810 - (23%)
Similarity:	312/810 - (38%)	Gaps:	245/810 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   667 GKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELKANSWLQFNADKRELYGLPLDDTVSRWQYRL 731
            |:.|...| |   ..|:|.|:: :.:|:.....|.|  ||.::|:...|.||||:  ..:..:.:
Zfish    88 GRVFRLQV-P---IKAKDSGSI-VKITEASKDVLPA--WLHWDAESGTLQGLPLE--TDKGVHYI 143

  Fly   732 SATDSGNASVTE-----TVEISVQQHRAV--------RTINHEISVFVRINEKP----------- 772
            |.:.|..:.|::     ::|:..::|...        ::.:::...|:..||:|
Zfish   144 SVSVSNESKVSQSPDVFSIEVHPEEHAETDPFQLAIQQSASNDAQPFICGNEEPVTVLTVILDAD 208

  Fly   773 --------------------------------------------------------GHNIDWQLK 781
                                                                    |..:.|:|.
Zfish   209 LTKMSSKQRVELLAKMKKFSGMGLQHMKILPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLG 273

  Fly   782 L---------INAVARTLDDSTNSA-----VVVREI-RQTPHDPHSATFVYFNET-------LPT 824
            .         |::|.....:.|.||     ||...| .:.||.|.... ...|.|       ||.
Zfish   274 CSLDQSSIPDISSVQVPAKEGTMSAQLGYPVVGWHIANKKPHVPKRVR-RQLNNTPTPIPSLLPP 337

  Fly   825 SECPEKELKDI--------------------------IARLDANRLSDLVQPQLGIKSITGQLIG 863
            :..||..::.:                          :.....||.|....|.||....|..::.
Zfish   338 TTYPEPPIRIVPTPTSPSIAPTSESSAPPVRGPVPLPVKPTIRNRDSAPSTPTLGPPLPTRVMVT 402

  Fly   864 ----SCQKDLTQV---------------KPTQHMTK----------------------------- 880
                :.|..:|:.               |||:...|
Zfish   403 TSTIAIQPTMTRPVYVGASVTPATPTTRKPTKRPPKKPKTTPIPREPKTTTTKPPRRSTPAVIGD 467

  Fly   881 -NVPPMPRNQVDRVNASLGQLLVYKVPADTFYDAND---NQLTLTLKTRDHLELSPRHWLQFDSK 941
             |:.|..||.:|:|||.:|.....|||:|||:|..|   ::|.|||:..:.: ::...|:||:|.
Zfish   468 SNIKPELRNPIDQVNAYVGTYFEVKVPSDTFFDKEDGTTDKLRLTLRKGNDV-VADDSWIQFNST 531

  Fly   942 NEEFYGIPKSGDIGSEEYLLVAEDSGGLSAHDALVVVVS--------PAPKRDFGFFFKAYLSIK 998
            ::..||:|.....|..||.:.|.|.|||.|.||..|.||        |.       .|.|.....
Zfish   532 SQLLYGLPDQEHAGKHEYFMQATDKGGLYAMDAFEVRVSMWGNSVKPPV-------LFTAVFDGD 589

  Fly   999 HERFNADLQRK--FVERVAKLNGDPTTGQIQIRSITTHHDSDGTIVNFYNTTLYRKHNSCREKEV 1061
            ......|:.:|  .|:::::..||..:..|.::|||    ....||.:.|.:|  :.:.|.:.::
Zfish   590 ARTVTNDIHKKILLVKKLSQSFGDRNSSTITLKSIT----KGSIIVEWTNNSL--QQSPCPKDQI 648

  Fly  1062 AMTRSVYLNSDLSLREAAKRALGPELNLTNFSVVPFSICHHTENIDTNQL-DYIPS--RPEEPTH 1123
            ........:.:.......|..:.|:...:|.:|...:.|.:...:...:: |..||  .|.....
Zfish   649 QQLSKKISDPEGKPSSIFKFTMEPDFRPSNITVRGTASCRNYMFVPLGEIPDPTPSPGTPAVGAG 713

  Fly  1124 KSSFGEDYMITFVWPIVIIVAMLVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKGIPVIFQD 1188
            :.|..:.|:.|.: |.|::.|:|:.|.||| .:.:.::|.||:.:   |::.:|..||:|:||.|
Zfish   714 RQSTDDVYLHTVI-PAVVVAAILLIAGIIA-MICYRKKRKGKLTI---EDQATFIKKGVPIIFAD 773

  Fly  1189 EYEE-KPEIGNKSPVILKDEKPPLLPPSY------NTSNMNGD--------NDVD----DYVPPP 1234
            |.:: ||...:..|:||::|||||.||.|      .|:.:|.|        :|.|    .|.|||
Zfish   774 ELDDSKPPPSSSMPLILQEEKPPLPPPEYPNMATPETTPLNQDLLGEYTPLHDEDPNAPPYQPPP 838

  Fly  1235 --SVVVGGREVRGKSPATPSYRKPPPYVSP 1262
              |..:.|:..|.|: .|| ||.|||||.|
Zfish   839 PFSTPMEGKGSRPKN-MTP-YRSPPPYVPP 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dg	NP_788363.1	alpha_DG_C	60..190	CDD:206765
		Dystroglycan_repeat	654..758	CDD:206636	23/103 (22%)
		Dystroglycan_repeat	885..986	CDD:206636	41/111 (37%)
		DAG1	989..1262	CDD:283181	83/298 (28%)
dag1	NP_775381.1	Dystroglycan_repeat	79..171	CDD:206636	23/91 (25%)
		alpha_DG_C	192..314	CDD:206765	14/121 (12%)
		CADG	476..570	CDD:214795	37/94 (39%)
		DAG1	580..866	CDD:283181	83/305 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576664
Domainoid	1	1.000	89	1.000	Domainoid score	I7801
eggNOG	1	0.900	-	-		E1_KOG3781
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007442
OrthoInspector	1	1.000	-	-		oto40823
orthoMCL	1	0.900	-	-		OOG6_107583
Panther	1	1.100	-	-	O	PTHR21559
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3922
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.770