DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dg and dgn-1

DIOPT Version :9

Sequence 1:	NP_788363.1	Gene:	Dg / 36773	FlyBaseID:	FBgn0034072	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001366742.1	Gene:	dgn-1 / 181283	WormBaseID:	WBGene00000961	Length:	584	Species:	Caenorhabditis elegans

Alignment Length:	666	Identity:	129/666 - (19%)
Similarity:	260/666 - (39%)	Gaps:	150/666 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   654 IIKTRLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELKANSWLQFNADKRELYGL 718
            ::.|.:....|..|:.|. |.|.:.:..|          |.||...|.  |||...  .:.|.|:
Worm    12 LVTTAISDTRVFIGELFE-HNLGDNYTIA----------TGKDSGPLP--SWLMVR--DQTLTGI 61

  Fly   719 PLDDTVSRW-------------------QYRLSATDSGNASVTETVEISVQQHRAVRTINHEISV 764
            |.::.|.|.                   :..:|...:.|....||      .|....::.:.|:.
Worm    62 PTENDVGRHTVMIKSRGRKPVYLYLNVEEETISPCGANNTFWMET------YHEQEASLANRINT 120

  Fly   765 FVRINEKPGHNIDWQLKLINAVARTLDDSTNSAVVVREI----RQTPHDPHSATFVY----FNET 821
            .:.:||.   .:|.::|.:...      |.|.:::.||:    ::..|..:.|.:..    |:|.
Worm   121 ALAMNEL---ELDPEIKTVRIY------SFNFSLINRELEEINQEAVHGQYMAIWKVACEDFDEA 176

  Fly   822 LPTSECPEKELKDIIARLDANRLSDLVQPQLGI----------KSITGQLIGSCQKDLTQ-VKPT 875
            |       ..:.|.:.|.|.:  .|.::...|.          |...........:..|: ::.|
Worm   177 L-------NYMDDFVDREDVD--YDSIKLAKGFFKPGMAPKPTKEAEDPTTAEYLRTTTELIRTT 232

  Fly   876 QHMTKNVPPMPRNQVDRVNASLGQLLVYKVPADTFYDANDN---QLTLTLKTRDHLELSPRHWLQ 937
            :.:|.| .|:..|::.....:.|::...::|::||.||.|.   ::.|::...|:.|:    |:
Worm   233 RRITDN-KPILLNRLPSFTCTRGEMCDLRIPSETFKDAEDGDTFKMKLSVLALDNAEV----WM- 291

  Fly   938 FDSKNEEFYGIP-KSGDIGSEEYLLVAEDSGGLSAHDALVVVVSPAPKRDFGFFFKAYLSIKHER 1001
            .:..|:...|:| ::|:.   .|.|.|.|..|..|.....|.|.||            |...| |
Worm   292 INESNKGLIGVPMRTGEF---NYRLEARDKAGQLASAPFQVNVKPA------------LPTNH-R 340

  Fly  1002 FNADLQRKFVERVAKLNGDPTTGQIQIRSITTH--------------HDSDGTIVNFYNTTLYRK 1052
            ...::.:...:::|.   :|:...:.:|::...              :.::.|:|.|.|.::  .
Worm   341 VQLEMDQPTPQQMAT---NPSKRNLLVRALARSLKAPVNSFTIQEIGYKNNKTMVAFSNNSI--P 400

  Fly  1053 HNSCREKEV-AMTRSVYLNSDLSLREAAKRALGPELNLTNFSVVPFSICHHTENIDTNQLDYIPS 1116
            :..|.|..: ||...:.:...:..:....:.:|.:..:...:::....|..|..|.|.
Worm   401 YKVCDEAAINAMASKMIIKQKMRTKTEFVKTMGNQFYVRTATMIRHGNCDETVEISTT------- 458

  Fly  1117 RPEEPTHKSSFGEDYMITFVWPIVIIVAMLVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKG 1181
               .||.:|....|..:..:..::.::.::..|.||.|.   |.::|||.:....|    :.:||
Worm   459 ---APTVESIQEADSQLLLICVLLFLLLLIAVAIIIYCA---CIKKSGKKKSTSTE----YVSKG 513

  Fly  1182 IPVIFQDEYEEKPEIGNKSPVILKDEKPPLLPPSYNTSNMNGDNDVDDYVPPPSVVVGGREVRGK 1246
            :||:|.||.||.......:|::.::|:|||....:       :|.:  |.|||.:......: |.
Worm   514 LPVVFPDEVEENDPTHAGTPMLAREERPPLKVSQH-------ENPL--YKPPPPIASNSPRL-GH 568

  Fly  1247 SPATPSYRKPPPYVSP 1262
            :.::.:.:...|::.|
Worm   569 ASSSSNQKLQSPFIPP 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dg	NP_788363.1	alpha_DG_C	60..190	CDD:206765
		Dystroglycan_repeat	654..758	CDD:206636	24/122 (20%)
		Dystroglycan_repeat	885..986	CDD:206636	26/104 (25%)
		DAG1	989..1262	CDD:283181	53/287 (18%)
dgn-1	NP_001366742.1	CADG	14..>72	CDD:214795	19/72 (26%)
		CADG	244..337	CDD:214795	27/112 (24%)
		DAG1	359..584	CDD:398879	48/253 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3781
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7583
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007442
OrthoInspector	1	1.000	-	-		oto18307
orthoMCL	1	0.900	-	-		OOG6_107583
Panther	1	1.100	-	-	LDO	PTHR21559
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3922
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.720