DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dg and DAG1

DIOPT Version :9

Sequence 1:	NP_788363.1	Gene:	Dg / 36773	FlyBaseID:	FBgn0034072	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001159400.3	Gene:	DAG1 / 1605	HGNCID:	2666	Length:	895	Species:	Homo sapiens

Alignment Length:	1056	Identity:	247/1056 - (23%)
Similarity:	378/1056 - (35%)	Gaps:	289/1056 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 LGVPLAAEIVPDETTSAAATRATEMVKPV-----DLDEQEISVDSGAVPAIDVEASATPTPSMSA 373
            |.|.:|....|.|.:.|......::...:     ||.|        |||.:......|.....|.
Human    22 LSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHE--------AVPTVVGIPDGTAVVGRSF 78

  Fly   374 RETQKPFSPYDATSSVSSSFSPVASIASGSEA-----GEDSTSVSTPHLSPANSP------TVMP 427
            |.|       ..|..::||...:...|:|.||     ..||.|.:...| |.::.      :|..
Human    79 RVT-------IPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGL-PLDTDKGVHYISVSA 135

  Fly   428 TELDRNG--LATTSSSSSSSASPPPSS---SVPTQATQPTTSASSFSSSSSTTTTSTTATVSTTT 487
            |.|..||  :..|||..|....|...|   ||.|.:..|....||..::....|..|....:..|
Human   136 TRLGANGSHIPQTSSVFSIEVYPEDHSELQSVRTASPDPGEVVSSACAADEPVTVLTVILDADLT 200

  Fly   488 TASSTATTTTTTTTLSESPKPNTVL-------NELELSTQ--LPIDD---FEGTATATQPTGTAT 540
                           ..:||....|       :|:||...  :|:.:   |:.:|..   .|...
Human   201 ---------------KMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRLFDMSAFM---AGPGN 247

  Fly   541 ATAIASTAAAAAATAAAATATATTANASATTAGESEFH-IESTTHRTISSKEGGEPDAISSGNNS 604
            |..:....|          ..:.....|.......:.| :|:.......|.:.|.|..    ...
Human   248 AKKVVENGA----------LLSWKLGCSLNQNSVPDIHGVEAPAREGAMSAQLGYPVV----GWH 298

  Fly   605 LANNELSTP--------ATPTSSVA----TTTASTPESSSISSNFVSTDYMEPQPEENSPPIIKT 657
            :||.:...|        ||||...|    ||....|.|..:             |...||.|
Human   299 IANKKPPLPKRVRRQIHATPTPVTAIGPPTTAIQEPPSRIV-------------PTPTSPAI--- 347

  Fly   658 RLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELKANSWLQFNADKRELYGLPLDD 722
                                                                |...|....|:.|
Human   348 ----------------------------------------------------APPTETMAPPVRD 360

  Fly   723 TVSRWQYRLSATDSGNASVTETVEISVQQHRAVRTINHEISVFVRINEKPGHNIDWQLKLINAVA 787
            .|           .|..:||.....::.|...:..|..     .|::| .|..:..|::....:.
Human   361 PV-----------PGKPTVTIRTRGAIIQTPTLGPIQP-----TRVSE-AGTTVPGQIRPTMTIP 408

  Fly   788 RTLDD---STNSAVVVREIR-QTPHDPHSATFVYFNETLPTSECPEKE------LKDIIARLDAN 842
            ..::.   :|......::.| .||.....:|    :.|..|:..|.|:      :..:..::...
Human   409 GYVEPTAVATPPTTTTKKPRVSTPKPATPST----DSTTTTTRRPTKKPRTPRPVPRVTTKVSIT 469

  Fly   843 RLSDLVQPQLGIKSITGQLIGSCQKDLTQVKPTQHMTKNVP--------PMPRNQVDRVNASLGQ 899
            ||.....|                   |:::.|   |..||        |..:|.:|||:|.:|.
Human   470 RLETASPP-------------------TRIRTT---TSGVPRGGEPNQRPELKNHIDRVDAWVGT 512

  Fly   900 LLVYKVPADTFYDAND---NQLTLTLKTRDHLELSPRHWLQFDSKNEEFYGIPKSGDIGSEEYLL 961
            ....|:|:|||||..|   ::|.||||.|:...:..:.|:||:|.::..||:|.|..:|..||.:
Human   513 YFEVKIPSDTFYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFM 577

  Fly   962 VAEDSGGLSAHDALVVVVSPAPKRDFGFFFKAYLSIKHERFNA-----------DLQRK--FVER 1013
            .|.|.|||||.||..:.|...|:.|..          ..||.|           |:.:|  .|::
Human   578 HATDKGGLSAVDAFEIHVHRRPQGDRA----------PARFKAKFVGDPALVLNDIHKKIALVKK 632

  Fly  1014 VAKLNGDPTTGQIQIRSITTHHDSDGTIVNFYNTTLYRKHNSCREKEVAMTRSVYLNSDLSLREA 1078
            :|...||.....|.:::||    ....:|.:.|.||  ....|.::::|.........|...|.|
Human   633 LAFAFGDRNCSTITLQNIT----RGSIVVEWTNNTL--PLEPCPKEQIAGLSRRIAEDDGKPRPA 691

  Fly  1079 AKRALGPELNLTNFSVVPFSICHHTENIDTNQLDYIPSR------PEEPTHKSSFGEDYMITFVW 1137
            ...||.|:...|:.:|.....|.|.:.|.......:||.      |:....|||..:.|:.|.:
Human   692 FSNALEPDFKATSITVTGSGSCRHLQFIPVVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVI- 755

  Fly  1138 PIVIIVAMLVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKGIPVIFQDEYEE-KPEIGNKSP 1201
            |.|::.|:|:.|.||| .:.:.::|.||:.|   |::.:|..||:|:||.||.:: ||...:..|
Human   756 PAVVVAAILLIAGIIA-MICYRKKRKGKLTL---EDQATFIKKGVPIIFADELDDSKPPPSSSMP 816

  Fly  1202 VILKDEKPPLLPPSY------NTSNMNGDNDVDDYVP------------PPSVVVGGREVRGKSP 1248
            :||::||.||.||.|      .|:.:|.|. :.:|.|            ||.......|.:|..|
Human   817 LILQEEKAPLPPPEYPNQSVPETTPLNQDT-MGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRP 880

  Fly  1249 --ATPSYRKPPPYVSP 1262
              .|| ||.|||||.|
Human   881 KNMTP-YRSPPPYVPP 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dg	NP_788363.1	alpha_DG_C	60..190	CDD:206765
		Dystroglycan_repeat	654..758	CDD:206636	10/103 (10%)
		Dystroglycan_repeat	885..986	CDD:206636	42/103 (41%)
		DAG1	989..1262	CDD:283181	89/312 (29%)
DAG1	NP_001159400.3	Required for laminin recognition	30..408		93/510 (18%)
		Dystroglycan_repeat	62..163	CDD:206636	27/108 (25%)
		O-glycosylated at one site	169..200		6/30 (20%)
		a_DG1_N2	182..304	CDD:408221	23/153 (15%)
		PRK14971	<303..>404	CDD:237874	28/185 (15%)
		Mucin-like domain	316..485		41/279 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..460		14/88 (16%)
		O-glycosylated at seven sites with GalNAc	463..485		5/43 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..498		5/22 (23%)
		Dystroglycan_repeat	498..602	CDD:206636	42/103 (41%)
		DAG1	606..895	CDD:398879	89/301 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..746		5/21 (24%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:20512930	776..782		1/5 (20%)
		Required for interaction with CAV3. /evidence=ECO:0000269\|PubMed:10988290	819..895		27/77 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..895		25/73 (34%)
		Required for binding DMD and UTRN	880..895		10/15 (67%)
		PPXY motif	889..892		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143729
Domainoid	1	1.000	102	1.000	Domainoid score	I6908
eggNOG	1	0.900	-	-		E1_KOG3781
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7583
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007442
OrthoInspector	1	1.000	-	-		oto88509
orthoMCL	1	0.900	-	-		OOG6_107583
Panther	1	1.100	-	-	O	PTHR21559
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3922
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.720