DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dg and Dag1

DIOPT Version :9

Sequence 1:	NP_788363.1	Gene:	Dg / 36773	FlyBaseID:	FBgn0034072	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001263410.1	Gene:	Dag1 / 13138	MGIID:	101864	Length:	893	Species:	Mus musculus

Alignment Length:	918	Identity:	212/918 - (23%)
Similarity:	355/918 - (38%)	Gaps:	234/918 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 NELELSTQLPIDDFEGTATATQPTGTATATAIASTAAAAAATAAAATATATTANASATTAGESEF 577
            |:||.|....:.||:............||....|...:......|::......:|:...|..|..
Mouse    42 NQLEASMHSVLSDFQEAVPTVVGIPDGTAVVGRSFRVSIPTDLIASSGEIIKVSAAGKEALPSWL 106

  Fly   578 HIESTTH----RTISSKEGGEPDAISSGNNSLANNELSTPATPTSSVATTTASTPESSSISSNFV 638
            |.:..:|    ..:.:.:|....::|:                 :.:....:..|::||:.|
Mouse   107 HWDPHSHILEGLPLDTDKGVHYISVSA-----------------ARLGANGSHVPQTSSVFS--- 151

  Fly   639 STDYMEPQPEENSPPIIKTRLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELKAN 703
                :|..||:::.|        .:|.:..:....|:|.. ..|::...:...:.|.|..::...
Mouse   152 ----IEVYPEDHNEP--------QSVRAASSDPGEVVPSA-CAADEPVTVLTVILDADLTKMTPK 203

  Fly   704 SWLQF-----NADKRELYGLPLDDTVSRWQYRLSATDSGNASVTETVE---------------IS 748
            ..:..     :..:.||:.:.|...|:...:.:||..:|..:..:.||               .|
Mouse   204 QRIDLLNRMQSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNS 268

  Fly   749 VQQHRAVRTINHEISVFVRI----------NEKPGHNIDWQL-KLINAVARTLDDSTNSAVVVRE 802
            |...|.|.|...|.::..::          |:||  .:..:| :.|:|....:.........::|
Mouse   269 VPDIRGVETPAREGAMSAQLGYPVVGWHIANKKP--TLPKRLRRQIHATPTPVTAIGPPTTAIQE 331

  Fly   803 ----IRQTPHDPHSATFVYFNETLPTSECPEKELKD--------------------IIARLDANR 843
                |..||..|..|         |.:|.....::|                    .:..:...|
Mouse   332 PPSRIVPTPTSPAIA---------PPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTR 387

  Fly   844 LSDL-------VQPQLGIKS-------ITGQLIGSCQKDLTQVKP-----------TQHMTK--N 881
            :|:.       ::|.|.|..       ||.....:.:..::..||           |:..||  .
Mouse   388 VSEAGTTVPGQIRPTLTIPGYVEPTAVITPPTTTTKKPRVSTPKPATPSTDSSTTTTRRPTKKPR 452

  Fly   882 VP-PMPR---------------------------------------NQVDRVNASLGQLLVYKVP 906
            .| |:||                                       |.:|||:|.:|.....|:|
Mouse   453 TPRPVPRVTTKAPITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFEVKIP 517

  Fly   907 ADTFYDAND---NQLTLTLKTRDHLELSPRHWLQFDSKNEEFYGIPKSGDIGSEEYLLVAEDSGG 968
            :|||||..|   ::|.||||.|:...:..:.|:||:|.::..||:|.|..:|..||.:.|.|.||
Mouse   518 SDTFYDNEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGG 582

  Fly   969 LSAHDALVVVVSPAPKRDFG-FFFKAYLSIKHERFNADLQRK--FVERVAKLNGDPTTGQIQIRS 1030
            |||.||..:.|...|:.|.. ..|||.|:........|:.:|  .|:::|...||.....|.:::
Mouse   583 LSAVDAFEIHVHKRPQGDKAPARFKARLAGDPAPVVNDIHKKIALVKKLAFAFGDRNCSSITLQN 647

  Fly  1031 ITTHHDSDGTIVNFYNTTLYRKHNSC-REKEVAMTRSVYLNSDLSLREAAKRALGPELNLTNFSV 1094
            ||    ....:|.:.|.||  ....| :|:.:.::|.: .:.:...|.|...||.|:....:.:|
Mouse   648 IT----RGSIVVEWTNNTL--PLEPCPKEQIIGLSRRI-ADENGKPRPAFSNALEPDFKALSIAV 705

  Fly  1095 VPFSICHHTENIDTNQLDYIPSRPEEP--------------THKSSFGEDYMITFVWPIVIIVAM 1145
            .....|.|        |.:||..|..|              ..|||..:.|:.|.: |.|::.|:
Mouse   706 TGSGSCRH--------LQFIPVAPPSPGSSAAPATEVPDRDPEKSSEDDVYLHTVI-PAVVVAAI 761

  Fly  1146 LVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKGIPVIFQDEYEE-KPEIGNKSPVILKDEKP 1209
            |:.|.||| .:.:.::|.||:.|   |::.:|..||:|:||.||.:: ||...:..|:||::||.
Mouse   762 LLIAGIIA-MICYRKKRKGKLTL---EDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKA 822

  Fly  1210 PLLPPSY------NTSNMNGDNDVDDYVP------------PPSVVVGGREVRGKSP--ATPSYR 1254
            ||.||.|      .|:.:|.|. |.:|.|            ||.......|.:|..|  .|| ||
Mouse   823 PLPPPEYPNQSMPETTPLNQDT-VGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTP-YR 885

  Fly  1255 KPPPYVSP 1262
            .|||||.|
Mouse   886 SPPPYVPP 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dg	NP_788363.1	alpha_DG_C	60..190	CDD:206765
		Dystroglycan_repeat	654..758	CDD:206636	19/123 (15%)
		Dystroglycan_repeat	885..986	CDD:206636	44/142 (31%)
		DAG1	989..1262	CDD:283181	91/310 (29%)
Dag1	NP_001263410.1	Required for laminin recognition. /evidence=ECO:0000250	28..406		65/407 (16%)
		O-glycosylated at one site. /evidence=ECO:0000250	47..69		3/21 (14%)
		Dystroglycan_repeat	60..161	CDD:206636	18/124 (15%)
		a_DG1_N2	180..302	CDD:375850	19/121 (16%)
		PRK14971	<301..>414	CDD:237874	19/123 (15%)
		Mucin-like domain. /evidence=ECO:0000250	314..483		26/177 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..498		16/118 (14%)
		O-glycosylated at seven sites with GalNAc. /evidence=ECO:0000250	461..483		0/21 (0%)
		Dystroglycan_repeat	496..600	CDD:206636	42/103 (41%)
		DAG1	604..893	CDD:310214	91/310 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..744		4/22 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	774..780		1/5 (20%)
		Required for interaction with CAV3. /evidence=ECO:0000250	817..893		28/77 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..893		26/73 (36%)
		Required for binding DMD and UTRN. /evidence=ECO:0000250	878..893		10/15 (67%)
		PPXY motif. /evidence=ECO:0000250	887..890		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833959
Domainoid	1	1.000	94	1.000	Domainoid score	I7520
eggNOG	1	0.900	-	-		E1_KOG3781
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3709
Isobase	1	0.950	-	0	Normalized mean entropy	S7583
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007442
OrthoInspector	1	1.000	-	-		oto92078
orthoMCL	1	0.900	-	-		OOG6_107583
Panther	1	1.100	-	-	O	PTHR21559
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3922
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.770