Protein Alignment Dg and Dg

DIOPT Version :10

• Sequence 1: NP_788363.1
• Gene: Dg / 36773
• FlyBaseID: FBgn0034072
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_061501533.1
• Gene: Dg / 1274848
• VectorBaseID: AGAMI1_006735
• Length: 1661
• Species: Anopheles gambiae
• Alignment Length: 1688
• Identity: 548/1688 - (32%)
• Similarity: 777/1688 - (46%)
• Gaps: 478/1688 - (28%)

  Fly    15 LFLLLDFVVWIHGERDFNVNDSQVPVIEP--KDVPAYKQDPYVTEL-MSCQNTPSEIVLSLLLKK 76
            :|||...:..   ..||:....|...:||  .:.|.....|.:::. :.|..|.|.|.|||:|:.
Mosquito    12 IFLLCTSITL---AEDFDFVPEQNDDVEPIAAEPPKVDSQPKLSKAGVRCLPTESTIQLSLILRA 73

  Fly    77 HDWSELTATKRAHVQAKLAKFFAIPKEFISLDSVSKRELRSMHKLAMRKGGKGNKNIETLNRRLG 141
            ..|..:..:.:....:|||::|.:|:|.|.:...:..:|..|.:.|::.|.|.::   |:.:.||
Mosquito    74 KSWKHVQTSLKQRTISKLAEYFLVPEESIIVRDATSNDLHKMVEKALQHGKKPSR---TVGKSLG 135

  Fly   142 RASFMIGCGPSYFVMGEPIAKQIAHQMKDGTIGALTEENFGLWFIWRKELKSRSNRKRRQSEGSG 206
            ...|.:|||.......:...:.:..|:.:  :..||..:||.|.||:::....:...:|......
Mosquito   136 WIGFPVGCGEKMSSSAKETVRNVNTQLAE--LRDLTGMDFGCWVIWKEQTGGAAASDKRIKREVD 198

  Fly   207 ADEDDYDYGDDDEEVAE-----PSTEVPPVTTHAHRHHHGALE---------------------- 244
            .|:|.|||  ||:|.||     .:||||    ||||||||:.|
Mosquito   199 PDDDYYDY--DDDEAAEDDDEGETTEVP----HAHRHHHGSSEQYSTKAEHHSSPTHATNKHTTN 257

  Fly   245 -----------------------------------------VSEKIVSPESVSSSA--------- 259
                                                     ..|...||..||.:|
Mosquito   258 NPDHTVETHHHQQHHHHHQQQHRHHANAEKQAEPWPRGGAATGEHRKSPVMVSLTAPSITAATTQ 322

  Fly   260 -----------------------------------------------VPLVPDVEEEIEESVSKL 277
                                                           |.:.|....::.||||:|
Mosquito   323 PSQPKRKHNHGLYDQVKERSAKKQAAALLAHTHQSDRAFQPATEPSHVAVHPFTPPDLRESVSQL 387

  Fly   278 ESVISKTIENTKNIK------------------------ELPVLGEADDGEDE--------EEV- 309
            ||.|||||.|.:.:|                        || :|.|.:..:||        |:|
Mosquito   388 ESTISKTIANNEQLKKDEETLLARKAKHKRIDIERIVETEL-LLPEIERLQDEVFRDDYVIEDVV 451

  Fly   310 ------------ELQQLGVPLAAE-------IVPDETTSAAATRATEMVKPVDLDEQEISVDSGA 355
                        :|.:. |||..|       ..|..|..|:..|:...|||     |.::|:...
Mosquito   452 RGPKFYDFSTQPQLDRF-VPLEPEPEKRQPATSPTTTLPASVNRSPTTVKP-----QYVTVEKTT 510

  Fly   356 VPAIDVEASATP--TPSMSARETQKPFSPYDATSSVS--------SSFS------PVASIASGSE 404
            .|.:...:...|  ||:...|.     ||..|.|:::        |.|:      .:..:.|..:
Mosquito   511 TPPMPTTSKQVPATTPNSKLRT-----SPTQAVSTLTVPRRHTDESLFTTKLPHPAITPVVSSID 570

  Fly   405 AGED-------STSVSTPHLSP-ANSPTVMPTELDRNGLATTSSSSS----------------SS 445
            |.||       :|::.|  ::| |.|..|.||:||.....||::.||                ::
Mosquito   571 ADEDAPSRSDTTTTIGT--INPTAQSRLVPPTKLDPTTTTTTTTLSSTPARSAAKTTTMTTTTAT 633

  Fly   446 ASPPPSSSVPTQ--------ATQPTTSASSFSSSSSTTT----TSTTATVSTTTT--ASSTATTT 496
            |:...:.::||:        ||.|.|:.::.:|::|||.    |:.|||.:||||  |||.:.|.
Mosquito   634 ATSTRAKTIPTELIELQTSPATMPLTTTTTTASTTSTTVSEEPTNPTATTTTTTTTPASSASATN 698

  Fly   497 TTTTTL---------------SESPKPNTVLNELELSTQLPIDDFEGTATATQPTGTATATAIAS 546
            |.:|.|               |.|....|::.|........|..|......:.|:.|.||||..:
Mosquito   699 TRSTNLFASVPLVKSDDEPAASSSSTIKTIVPEATTEKSSTISSFSSAVEYSTPSSTTTATATTT 763

  Fly   547 TAAAAAATAAAATA-------------------------TATTANASA---------TTAGESEF 577
            .||..:.|:..|::                         .:|.||:.|         ||.|..:.
Mosquito   764 IAALPSITSTPASSWHLGMDEDEEASYESKEFFDEIDSKPSTFANSEAVSISSSTTTTTHGSEDQ 828

  Fly   578 HIESTTHRTIS--------------------------------------------------SKEG 592
            .....|..|:|                                                  .:|.
Mosquito   829 GTSDYTTTTVSYVPLTTTPTTQEELSRYATNLDRSPFGRKINDEDISADQEEEDQEEGEDIDEEE 893

  Fly   593 GEPDAISSG----------------NNSLANNEL------------------------------- 610
            .|.|..|.|                :|...:.||
Mosquito   894 EEEDYFSQGPTSTQRSVSTFTTPKQDNEEEDKELEYENYDDEYDDEEEGAIELTTQPDPRVLSST 958

  Fly   611 ---------------------------------------STPATPTSSVATTTASTPESSSISSN 636
                                                   :|..|.||:..|||.:|.|:|:.:|.
Mosquito   959 TTTERPMPSSTEPSTTPTTVTMPTTTPSTTTTTTTEAPTTTTTTTTSTTTTTTTTTTEASTTTST 1023

  Fly   637 FVSTDYMEPQPEENSPPIIKTRLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELK 701
            .::|:..||   .|.||||:.|:.|.|:.:||.|.:.|..|||:|.||..||.|.|.|.....||
Mosquito  1024 MLTTELDEP---TNLPPIIRNRIPKQAIPAGKVFRYQVPLETFHDNEDGNNLSLELLDARDQPLK 1085

  Fly   702 ANSWLQFNADKRELYGLPLDDTVSRWQYRLSATDSGNASVTETVEISVQQHRAVRTINHEISVFV 766
            .:||:|||.|.:|:|||||:..||||.|:|.||||||.:|||.|:|.||||::.|::|||||:.:
Mosquito  1086 PSSWIQFNEDTKEIYGLPLEKDVSRWPYKLRATDSGNLTVTEKVDIQVQQHKSHRSLNHEISLAL 1150

  Fly   767 RINEKPGHNIDWQLKLINAVARTLDDSTNSAVVVREIRQTPHDPHSATFVYFNETLPTSECPEKE 831
            |:|.|...|:||.::....::..|.|.|.|.::||:||.:..||..|||||.|||||...|||::
Mosquito  1151 RLNRKFASNVDWHIETARGISVVLGDVTLSNIIVRDIRNSIQDPSLATFVYTNETLPKDRCPEEK 1215

  Fly   832 LKDIIARLDANRLSDLVQPQLGIKSITGQLIGSCQKDLT--QVKPTQHMTKNVPPMPRNQVDRVN 894
            |.:::|.|....|:|.:.|.:.:||:.||.|..|.| :|  :|||||.:.:|..|..|||||:||
Mosquito  1216 LDELVALLTEEALNDALNPDITVKSVQGQQIAQCTK-VTPPKVKPTQSIQRNYAPQTRNQVDQVN 1279

  Fly   895 ASLGQLLVYKVPADTFYDAND-NQLTLTLKTRDHLELSPRHWLQFDSKNEEFYGIPKSGDIGSEE 958
            |::|.|||:|||.|||||..| |:|.:.|.|.|...|.|.|||||||||:||||:|::.|||.:|
Mosquito  1280 ATVGHLLVFKVPVDTFYDPEDGNELKMKLLTTDRNTLDPNHWLQFDSKNQEFYGVPRTNDIGRKE 1344

  Fly   959 YLLVAEDSGGLSAHDALVVVVSPAPKRDFGFFFKAYLSIKHERFN-ADLQRKFVERVAKLNGDPT 1022
            |||:|||..||:|.|||||||:|..|||:...|:..|.|.||:|| |.:||:|:||:|::.||.:
Mosquito  1345 YLLMAEDREGLTATDALVVVVNPHHKRDYSVLFELTLDISHEQFNTAQVQRRFIERLAQVFGDAS 1409

  Fly  1023 TGQIQIRSITTHHDSDGTIVNFYNTTLYRKHNSCREKEVAMTRSVYLNSDLSLREAAKRALGPEL 1087
            |..|:|..|...|.:....|:|:||||.|:|..|.::|:...|::.|:.|.::|...:..||.|.
Mosquito  1410 THYIKIHHIRPIHHTGQVQVSFFNTTLSRQHQRCPQEEIETLRNILLHQDSTIRAKVREILGQEF 1474

  Fly  1088 NLTNFSVVPFSICHHTENIDTNQLDYIPSRPEEPTHKSSFGEDYMITFVWPIVIIVAMLVAASII 1152
            :|.|.|:||...||   ..||..  :..|.||:...|....:||::|||.|.|||:.||:.|:||
Mosquito  1475 SLQNVSLVPLDNCH---GFDTPH--HATSEPEKAAPKPISKDDYLLTFVLPSVIIIVMLLIAAII 1534

  Fly  1153 ACCLHWCRQRSGKMEL-----------------GDEEERKSFRAKGIPVIFQDEYEEKPEIGNKS 1200
            ||.| :.|:.:|||||                 |.:|||||||:||||||||||.:|||||||||
Mosquito  1535 ACIL-YKRRLTGKMELEYINFKPIASSSSSNPQGTDEERKSFRSKGIPVIFQDELDEKPEIGNKS 1598

  Fly  1201 PVILKDEKPPLLPPSYNTSNMNGDN-DVDDYVPPPSVVVGGREVRGKSPATPSYRKPPPYVSP 1262
            ||||||||||||||||:::|.:||| |||:||||..|:|||||.|||||.|||||:|||||||
Mosquito  1599 PVILKDEKPPLLPPSYSSTNHDGDNEDVDEYVPPQPVIVGGRESRGKSPVTPSYRRPPPYVSP 1661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dg	NP_788363.1	alpha_DG_C	60..190	CDD:473046	36/129 (28%)
		Dystroglycan_repeat	654..758	CDD:206636	56/103 (54%)
		Dystroglycan_repeat	885..986	CDD:206636	64/101 (63%)
		DAG1	989..1262	CDD:461655	149/291 (51%)
Dg	XP_061501533.1	None