Protein Alignment Dg and Dag1

DIOPT Version :10

• Sequence 1: NP_788363.1
• Gene: Dg / 36773
• FlyBaseID: FBgn0034072
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_446149.1
• Gene: Dag1 / 114489
• RGDID: 621890
• Length: 893
• Species: Rattus norvegicus
• Alignment Length: 997
• Identity: 238/997 - (23%)
• Similarity: 369/997 - (37%)
• Gaps: 288/997 - (28%)

  Fly   384 DATSSVSSSFS---PVASIASGSE------AGEDSTSVSTPHLSP-ANSPTVMPTELDRNGLATT 438
            |.|:.|..||.   |...|||..|      ||:::.. |..|..| ::....:|.:.|: |:...
  Rat    67 DGTAVVGRSFRVSIPTDLIASSGEIIKVSAAGKEALP-SWLHWDPHSHILEGLPLDTDK-GVHYI 129

  Fly   439 SSSS----SSSASPPPSSSV------PTQATQPTTSASSFSSSSSTTTTSTTATVSTTTTASSTA 493
            |.|:    ::.:..|.::||      |...::| .|..:.||......:|..|.....|..:...
  Rat   130 SVSAARLGANGSHVPQTASVFSIEVYPEDHSEP-QSVRAASSDPGEVVSSACAADEPVTVLTVIL 193

  Fly   494 TTTTTTTTLSESPKPN-TVLNELELSTQLPIDD-----------FEGTATATQPTGTATATAIAS 546
            ....|..|    ||.. .:||.::..:::.:::           |:.:|....|..       |.
  Rat   194 DADLTKMT----PKQRIDLLNRMQSFSEVELNNMKLVPVVNNRLFDMSAFMAGPGN-------AK 247

  Fly   547 TAAAAAATAAAATATATTANASATTAGESEFHIESTTHRTISSKEGGEPDAISSGNNSLANNELS 611
            ......|..:.....:...|:.....|     :|:.......|...|.|..    ...:||.:.:
  Rat   248 KVVENGALLSWKLGCSLNQNSVPDIRG-----VETPAREGTMSAHLGYPVV----GWHIANKKPT 303

  Fly   612 TP--------ATPTSSVA---TTTA---------STPESSSISSNFVSTDYMEPQPEENSP---- 652
            .|        ||||...|   .|||         .||.|.:|:.   .|:.|.|...:..|
  Rat   304 LPKRIRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAP---PTETMAPPVRDPVPGKPT 365

  Fly   653 ----------------PIIKTRLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELK 701
                            ||..||:.:...|         :|         |.:|..||.....|..
  Rat   366 VTIRTRGAIIQTPTLGPIPPTRVSEAGTT---------VP---------GQIRPTLTIPGYVEPT 412

  Fly   702 ANSWLQFNADKRELYGLPLDDTVSRWQYRLS----ATDSGNASVTETVEISVQQHRAVRTINHEI 762
            |               :....|.:..:.|:|    ||.|.::|.|.|
  Rat   413 A---------------VVTPPTTTTKKPRVSTPKPATPSTDSSTTTT------------------ 444

  Fly   763 SVFVRINEKPGHNIDWQLKLINAVARTLDDSTNSAVVVREIRQTPHDPHSATFVYFNETLPTSEC 827
                                                  |...:.|..|.....|       |::.
  Rat   445 --------------------------------------RRPTKKPRTPRPVPRV-------TTKA 464

  Fly   828 PEKELKDIIARLDANRLSDLVQPQLGIKSITGQLIGSCQKDLTQVKPTQHMTKNVPPMPRNQVDR 892
            |       |.||:.      ..|...|::.|..:             .:....|..|..:|.:||
  Rat   465 P-------ITRLET------ASPPTRIRTTTSAV-------------PRGGEANQRPELKNHIDR 503

  Fly   893 VNASLGQLLVYKVPADTFYDAND---NQLTLTLKTRDHLELSPRHWLQFDSKNEEFYGIPKSGDI 954
            |:|.:|.....|:|:|||||..|   ::|.||||.|:...:..:.|:||:|.::..||:|.|..:
  Rat   504 VDAWVGTYFEVKIPSDTFYDNEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHV 568

  Fly   955 GSEEYLLVAEDSGGLSAHDALVVVVSPAPKRDFG-FFFKAYLSIKHERFNADLQRK--FVERVAK 1016
            |..||.:.|.|.|||||.||..:.|...|:.|.. ..|||.|:........|:.:|  .|:::|.
  Rat   569 GKHEYFMHATDKGGLSAVDAFEIHVHKRPQGDKAPARFKAKLAGDPAPVVNDIHKKIALVKKLAF 633

  Fly  1017 LNGDPTTGQIQIRSITTHHDSDGTIVNFYNTTLYRKHNSC-REKEVAMTRSVYLNSDLSLREAAK 1080
            ..||.....|.:::||    ....:|.:.|.||  ....| :|:.|.::|.: .:.:...|.|..
  Rat   634 AFGDRNCSSITLQNIT----RGSIVVEWTNNTL--PLEPCPKEQIVGLSRRI-ADENGKPRPAFS 691

  Fly  1081 RALGPELNLTNFSVVPFSICHHTENIDTNQLDYIPSRPEEP--------------THKSSFGEDY 1131
            .||.|:....:.:|.....|.|        |.:||..|..|              ..|||..:.|
  Rat   692 NALEPDFKALSVAVAGSGSCRH--------LQFIPVAPPSPGTSAAPATEVPDRDPEKSSEDDVY 748

  Fly  1132 MITFVWPIVIIVAMLVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKGIPVIFQDEYEE-KPE 1195
            :.|.: |.|::.|:|:.|.||| .:.:.::|.||:.|   |::.:|..||:|:||.||.:: ||.
  Rat   749 LHTVI-PAVVVAAILLIAGIIA-MICYRKKRKGKLTL---EDQATFIKKGVPIIFADELDDSKPP 808

  Fly  1196 IGNKSPVILKDEKPPLLPPSY------NTSNMNGDNDVDDYVP------------PPSVVVGGRE 1242
            ..:..|:||::||.||.||.|      .|:.:|.|. |.:|.|            ||.......|
  Rat   809 PSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDT-VGEYTPLRDEDPNAPPYQPPPPFTAPME 872

  Fly  1243 VRGKSP--ATPSYRKPPPYVSP 1262
            .:|..|  .|| ||.|||||.|
  Rat   873 GKGSRPKNMTP-YRSPPPYVPP 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dg	NP_788363.1	alpha_DG_C	60..190	CDD:473046
		Dystroglycan_repeat	654..758	CDD:206636	20/107 (19%)
		Dystroglycan_repeat	885..986	CDD:206636	42/103 (41%)
		DAG1	989..1262	CDD:461655	92/310 (30%)
Dag1	NP_446149.1	Dystroglycan_repeat	60..161	CDD:206636	24/95 (25%)
		a_DG1_N2	180..302	CDD:465761	21/141 (15%)
		PRK12323	<311..>402	CDD:481241	24/111 (22%)
		Dystroglycan_repeat	496..600	CDD:206636	42/103 (41%)
		DAG1	604..893	CDD:461655	92/310 (30%)