Protein Alignment CG8405 and TMEM259

DIOPT Version :10

• Sequence 1: NP_725521.1
• Gene: CG8405 / 36772
• FlyBaseID: FBgn0034071
• Length: 960
• Species: Drosophila melanogaster
• Sequence 2: XP_005259732.1
• Gene: TMEM259 / 91304
• HGNCID: 17039
• Length: 661
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 277/648 - (42%)
• Similarity: 354/648 - (54%)
• Gaps: 160/648 - (24%)

  Fly    35 PGGLGGGG--------------QNNMMNMRDRLFHAIYFRAAATYAELVPRKVQLTIEFLLLAKA 85
            ||..||||              .|.::|:|||||||::|:.|.||:.|.|...:...||.:|.||
Human    12 PGPNGGGGGPAPARGPRTPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKA 76

  Fly    86 LLFFFTLIYVHNSFIKNPCTCLQDVKN-WPREGVIRVEI---------------------IPHLA 128
            |...|.|.|:|..|.::|..||:.|:: |||||::|||:                     .|.|
Human    77 LFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGL- 140

  Fly   129 EKRAIWQGIKRDQEIVRSLKDSYYYGIGPQTRQNHETLKRYESILGKLGLPVRPTFAYSNESLYY 193
               |:..|...|.|               ...:...|::.:.:  ..:.:|.||.|....|.
Human   141 ---AVEPGSNLDME---------------DEEEEELTMEMFGN--SSIKVPGRPQFELDIEP--- 182

  Fly   194 YFDAINILDTYDHPNAIQLKNEEDD------------EEQYIVEYSLEYGHLRLSSSTRKRLRIP 246
                    ..:..|::.:..|:..:            :::||||||||||.||||.:||:||.||
Human   183 --------KVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIP 239

  Fly   247 VLTVQLDPNTDKCFGDSLTRYLLKRLLGYDDLLMASVRTIAEQEENKGYLRNVITGEHYRFVSMW 311
            |:.|.|||..|:||||..:|.||...|||||:||:||:.:||.|||||:||||::||||||||||
Human   240 VMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMW 304

  Fly   312 WAAWSSYPAAFCVMLLFTFSVSMLLRYSHHQIFVFIVDLLQMLEYNVSARFPIAPLLTVILALVG 376
            .|. :||.|||.:|::||.|||||||||||||||||||||||||.|::..||.||||||||||||
Human   305 MAR-TSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVG 368

  Fly   377 MEAIMSEFFNDTTTAFYIILIVWIADQYDAICCHTSITKRHWLRFFYLYHFAFYAYHYRFSGQYR 441
            |||||||||||||||||||||||:||||||||||||.:||||||||||||||||||||||:|||.
Human   369 MEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYS 433

  Fly   442 TLALLSSYLFTQ-----------------------------------HSMVFFFHRYELPAIMAQ 471
            :|||::|:||.|                                   |||::|||.||||||:.|
Human   434 SLALVTSWLFIQVRPGRQAGGRPAVPFQAGEAAAGEDALWGRPKRAEHSMIYFFHHYELPAILQQ 498

  Fly   472 ---HQVFI----------------ITRNQGAAAAA-------------AAAAAGAGGAEAAGGGA 504
               .::.:                :..|.||.|.|             :..|:|:.|..||...:
Human   499 VRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPGASGSPGPVAAAPSS 563

  Fly   505 GAGAAAGGQQGDGGAGGGGIGAGQQASMQRARLIVT--RLFSQLAAQRHQQEPRPP-GPTAAV 564
            ...|||    ....|.||.:|     .|.....|:|  ...|.|:|...::.|..| ||...:
Human   564 LVAAAA----SVAAAAGGDLG-----WMAETAAIITDASFLSGLSASLLERRPASPLGPAGGL 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8405	NP_725521.1	Membralin	44..416	CDD:462877	199/405 (49%)
TMEM259	XP_005259732.1	Membralin	35..408	CDD:462877	199/405 (49%)
		PRK14959	<516..>661	CDD:184923	27/111 (24%)