DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8405 and Tmem259

DIOPT Version :9

Sequence 1:	NP_001286475.1	Gene:	CG8405 / 36772	FlyBaseID:	FBgn0034071	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	XP_038934570.1	Gene:	Tmem259 / 299608	RGDID:	1311136	Length:	598	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	275/588 - (46%)
Similarity:	352/588 - (59%)	Gaps:	82/588 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PGGLGGGG-------------QNNMMNMRDRLFHAIYFRAAATYAELVPRKVQLTIEFLLLAKAL 86
            |.|.||||             .|.::|:|||||||::|:.|.||:.|.|...:...||.:|.|||
  Rat    12 PNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKAL 76

  Fly    87 LFFFTLIYVHNSFIKNPCTCLQDVKN-WPREGVIRVEIIPHLAEKRAIWQGIKRDQEIVRSLKDS 150
            ...|.|.|:|..|.::|..||:.|:: ||||||:|||:..:.:....|.|           ..|.
  Rat    77 FVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQ-----------FCDG 130

  Fly   151 YYYGI-----GPQTRQNHETLKRYESILGKLGLPVRP-TFAYSNESLYYYFDAINILDTYDHPNA 209
            ...|:     |.:..:...:::.:.:...|..|.:.| .|.....:     ||:|  |:.|.|..
  Rat   131 GLGGLDLEPGGLELEEEELSVEMFTNSSIKFELDIEPKVFKPPGGA-----DALN--DSQDFPFP 188

  Fly   210 IQLKNEEDDEEQYIVEYSLEYGHLRLSSSTRKRLRIPVLTVQLDPNTDKCFGDSLTRYLLKRLLG 274
             :...:...:::||||||||||.||||.:||:||.|||:.|.|||..::||||..:|.||...||
  Rat   189 -ETPAKAWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTREQCFGDRFSRLLLDEFLG 252

  Fly   275 YDDLLMASVRTIAEQEENKGYLRNVITGEHYRFVSMWWAAWSSYPAAFCVMLLFTFSVSMLLRYS 339
            |||:||:||:.:||.|||||:||||::||||||||||.|. :||.|||.:|::||.|||||||||
  Rat   253 YDDVLMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMAR-TSYLAAFVIMVIFTLSVSMLLRYS 316

  Fly   340 HHQIFVFI------------------------VDLLQMLEYNVSARFPIAPLLTVILALVGMEAI 380
            ||||||||                        ||||||||.|::..||.||||||||||||||||
  Rat   317 HHQIFVFIGESQPAGGGVGSPQALMGGRPVPAVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAI 381

  Fly   381 MSEFFNDTTTAFYIILIVWIADQYDAICCHTSITKRHWLRFFYLYHFAFYAYHYRFSGQYRTLAL 445
            |||||||||||||||||||:|||||||||||:.:||||||||||||||||||||||:|||.:|||
  Rat   382 MSEFFNDTTTAFYIILIVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLAL 446

  Fly   446 LSSYLFTQHSMVFFFHRYELPAIMAQ---HQVFIITRNQGAAAAAA----------AAAAGAGGA 497
            ::|:||.||||::|||.||||||:.|   .::.:.|...|.....|          :.|......
  Rat   447 VTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSP 511

  Fly   498 EAAGGGAGAGAAAGGQQGDGGAGGGGIGAGQQAS--MQRARLIVTRLF-SQLAAQRHQQEPRPPG 559
            ..|.|.:.:.|..||..|.|..|.|...:|....  .:.|.:|....| |.|:|.  ..|.||..
  Rat   512 PLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSAS--LLERRPAA 574

  Fly   560 PTA 562
            |:|
  Rat   575 PSA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8405	NP_001286475.1	Membralin	44..416	CDD:286789	199/402 (50%)
Tmem259	XP_038934570.1	Membralin	34..417	CDD:401625	199/402 (50%)
Tmem259	XP_038934570.1	KLF9_13_N-like	<479..596	CDD:425361	25/101 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338630
Domainoid	1	1.000	302	1.000	Domainoid score	I1361
eggNOG	1	0.900	-	-		E1_KOG2092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1439
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006624
OrthoInspector	1	1.000	-	-		oto97966
orthoMCL	1	0.900	-	-		OOG6_108561
Panther	1	1.100	-	-	LDO	PTHR21650
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5625
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.790