DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8405 and Tmem259

DIOPT Version :9

Sequence 1:	NP_001286475.1	Gene:	CG8405 / 36772	FlyBaseID:	FBgn0034071	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001346561.1	Gene:	Tmem259 / 216157	MGIID:	2177957	Length:	598	Species:	Mus musculus

Alignment Length:	585	Identity:	271/585 - (46%)
Similarity:	348/585 - (59%)	Gaps:	82/585 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PGGLGGGG-------------QNNMMNMRDRLFHAIYFRAAATYAELVPRKVQLTIEFLLLAKAL 86
            |.|.||||             .|.::|:|||||||::|:.|.||:.|.|...:...||.:|.|||
Mouse    12 PNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKAL 76

  Fly    87 LFFFTLIYVHNSFIKNPCTCLQDVKN-WPREGVIRVEIIPHLAEKRAIWQ-------GIKRDQEI 143
            ...|.|.|:|..|.::|..||:.|:: ||||||:|||:..:.:....|.|       |::.:..
Mouse    77 FVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPG- 140

  Fly   144 VRSLKDSYYYGIGPQTRQNHETLKRYESILGKLGLPVRPTFAYSNESLYYYFDAINILDTYDHPN 208
                        |.:..:...|::.:.:...|..|.:.|.........    ||:|  |:.|.|.
Mouse   141 ------------GLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGA----DALN--DSQDFPF 187

  Fly   209 AIQLKNEEDDEEQYIVEYSLEYGHLRLSSSTRKRLRIPVLTVQLDPNTDKCFGDSLTRYLLKRLL 273
            . :...:...:::||||||||||.||||.:||:||.|||:.|.|||..|:||||..:|.||...|
Mouse   188 P-ETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFL 251

  Fly   274 GYDDLLMASVRTIAEQEENKGYLRNVITGEHYRFVSMWWAAWSSYPAAFCVMLLFTFSVSMLLRY 338
            ||||:||:||:.:||.|||||:||||::||||||||||.|. :||.|||.:|::||.||||||||
Mouse   252 GYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMAR-TSYLAAFVIMVIFTLSVSMLLRY 315

  Fly   339 SHHQIFVFI------------------------VDLLQMLEYNVSARFPIAPLLTVILALVGMEA 379
            |||||||||                        ||||||||.|::..||.|||||||||||||||
Mouse   316 SHHQIFVFIGESQPAGGGVGSPQALMGGRPVPAVDLLQMLEMNMAIAFPAAPLLTVILALVGMEA 380

  Fly   380 IMSEFFNDTTTAFYIILIVWIADQYDAICCHTSITKRHWLRFFYLYHFAFYAYHYRFSGQYRTLA 444
            |||||||||||||||||.||:|||||||||||:.:||||||||||||||||||||||:|||.:||
Mouse   381 IMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLA 445

  Fly   445 LLSSYLFTQHSMVFFFHRYELPAIMAQ---HQVFIITRNQGAAAAAA----------AAAAGAGG 496
            |::|:||.||||::|||.||||||:.|   .::.:.|...|.....|          :.|.....
Mouse   446 LVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPS 510

  Fly   497 AEAAGGGAGAGAAAGGQQGDGGAGGGGIGAGQQAS--MQRARLIVTRLF-SQLAAQRHQQEPRPP 558
            ...|.|.:.:.|..||..|.|..|.|...:|....  .:.|.:|....| |.|:|...::.|..|
Mouse   511 PPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAP 575

Fly 559 558
Mouse 576 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8405	NP_001286475.1	Membralin	44..416	CDD:286789	198/403 (49%)
Tmem259	NP_001346561.1	Membralin	35..417	CDD:313042	197/402 (49%)
Tmem259	NP_001346561.1	Herpes_ICP4_C	484..>596	CDD:332854	21/92 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835037
Domainoid	1	1.000	302	1.000	Domainoid score	I1403
eggNOG	1	0.900	-	-		E1_KOG2092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1459
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006624
OrthoInspector	1	1.000	-	-		oto94453
orthoMCL	1	0.900	-	-		OOG6_108561
Panther	1	1.100	-	-	LDO	PTHR21650
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5625
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750