DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP2353 and egflam

DIOPT Version :9

Sequence 1:	NP_001286474.1	Gene:	SP2353 / 36771	FlyBaseID:	FBgn0034070	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_009299464.1	Gene:	egflam / 799405	-ID:	-	Length:	1056	Species:	Danio rerio

Alignment Length:	1239	Identity:	279/1239 - (22%)
Similarity:	443/1239 - (35%)	Gaps:	448/1239 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 ALSAAQSASPAGNEN-----GEDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVN 188
            |::|...:.|:...|     |..::|| || ||   :..|||:.::            :.:..::
Zfish   227 AVNAHGISPPSAINNPVRTLGSVDTGS-GD-YD---VYISNSDNKD------------EDKLDID 274

  Fly   189 SNDYYISAESINF-NSESEGQEQQ---DVADFKAASTMLPSSVPPTPSRSTTRATAS--TTTTTT 247
            .:||....|.:.| :|:..|:..|   .:......:.:.....|.:|:.|.|..|||  ||||||
Zfish   275 DSDYDFFIEEMKFPSSKKSGRRSQLRSRIGTPGNGNVIYRMRTPVSPNISFTPTTASIWTTTTTT 339

  Fly   248 TTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNT 312
            ||....|.:                                                 :|:.|..
Zfish   340 TTVTMTTTS-------------------------------------------------RTTATPI 355

  Fly   313 AKNRRKYPNVTSNKVQMHITR-ETNRLENISAAEPAVVGAAMTTDRSTPTCNLDCGSDGICALEA 376
            .:.....|.|.|:...|...: |..|:.::...|..                  |.:|..|..:.
Zfish   356 VRTATPPPAVPSSSPSMTPWKGERARVYDVPCEETV------------------CPADSFCINDY 402

  Fly   377 TAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLS 441
            ....|||.|..|:.|:.|.|.:..:.|:|...|.:.|..|..:|:..|:.:||:.|:.||::|..
Zfish   403 DTGGSRCHCNLGRQGDFCSEGLTINFPKFYGYSHMTFEPLKNSYQSFQISLEFKAEAEDGLLLYC 467

  Fly   442 GERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTK 506
            ||.:...|||.:|.|.:|.:.:.|:||:|...:.|..:|::.:|::|.|:|...:.||.|::.|.
Zfish   468 GENEHGRGDFTSLALIRGKLHYRFNCGTGAAQIISDSSIVIGQWHTVTIFRDGMNGWLRLDNDTP 532

  Fly   507 VQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHPLGDVIN 571
            |..||.|.:::||||..:||||..|...|.:.:....||.||::....|.........|.|:.::
Zfish   533 VSSRSQGQYTKITFRTALFLGGAPNGYWLVRAVGTNRGFQGCMQSLTVNSKAIDIRPWPKGNALS 597

  Fly   572 GFDIQDCSTDKCVRYPCQHGGKCLPS-DQGAICLCPIGFVGDLCEIRMDLQVPAFNGSSF-LRYA 634
            |.||.:||...|.:..|.:||.|..: ..|.|||||:|:.|.|||....|.:|.||.|.| ...|
Zfish   598 GADIGECSNSVCEKVTCANGGICFANRADGFICLCPLGYKGFLCEESFLLSLPQFNQSMFSYASA 662

  Fly   635 PLGDSA---LIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSE 696
            |...|:   |.::|.:||.:|...||.:||:......||:::.|..|:|||.||.|||..::|||
Zfish   663 PWPQSSHNYLSFMEFEVTFQPTSPDGTLLYTDDATSRDFLSISLVAGYVEFRFDCGSGATVIRSE 727

  Fly   697 HSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYK 761
            .::::..||.:::||||:..:|:||..:.|..::...|..:.....|::|||.:.|..      |
Zfish   728 EAIAMNVWHELRVSRTAKNGILQVDNQRPVEGMAEGAFTQIKCSSPLYIGGVPNYDIT------K 786

  Fly   762 PF------FVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESYECRCS 820
            |.      :.|.:|:|.:|...:.:......|.|:.|..|.||..||.....|..:.:.|:|.|:
Zfish   787 PSAGILRPYSGSVQKITLNDRGIELNPGQAFGVNVLNAAHPCVDNPCANGGTCRAKWDEYDCDCA 851

  Fly   821 IHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTT 885
            :                                             .:..||
Zfish   852 L---------------------------------------------GYDGKH------------- 858

  Fly   886 TSTTSTTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATST 950
                                                        .|||.......|.|
Zfish   859 --------------------------------------------CQKECGNYCLNTVT------- 872

  Fly   951 TSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTS 1015

Zfish   873 ----------------------------------------------------------------- 872

  Fly  1016 LQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDM 1080

Zfish   873 ----------------------------------------------------------------- 872

  Fly  1081 KRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTS 1145
                                                                   |.:::.|.|.
Zfish   873 -------------------------------------------------------ESIEIPQFTG 882

  Fly  1146 STPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRI 1210
            .                                       ||..|::.|.:.::.....:|.:|.
Zfish   883 R---------------------------------------SYLTYDNRDILKRISGSRTNLFMRF 908

  Fly  1211 KTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAI 1275
            |:.|::|::||.| :.....:.||||||::.|.|.|.|:||||...:..||| .|||.||||:|:
Zfish   909 KSTSKDGLLLWRG-ESPMRANSDYLSLGLQDGSLIFSYNLGSGAATVVINGT-FSDGKWHRVKAV 971

  Fly  1276 RNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGE 1340
            |:.|.|.|.||.....|.|:|||:||||.:..||:|||.::...|:::|..|:|||||...||.:
Zfish   972 RDGQSGKLTVDDYGAQTGRSPGKMRQLNINGDLYIGGMKEIALHTNRQYMRGLVGCISHFTLATD 1036

  Fly  1341 MKLN 1344
            ..|:
Zfish  1037 YHLS 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_001286474.1	FXa_inhibition	53..82	CDD:291342
		LamG	404..555	CDD:238058	52/150 (35%)
		EGF	583..612	CDD:278437	12/29 (41%)
		LamG	625..774	CDD:238058	52/158 (33%)
		LamG	1205..1340	CDD:214598	63/134 (47%)
egflam	XP_009299464.1	FN3	35..142	CDD:238020
		FN3	151..237	CDD:238020	2/9 (22%)
		LamG	431..581	CDD:238058	52/149 (35%)
		EGF_CA	600..642	CDD:238011	18/41 (44%)
		LamG	658..805	CDD:238058	48/152 (32%)
		EGF	828..858	CDD:278437	8/74 (11%)
		Laminin_G_2	908..1033	CDD:280389	59/126 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17288at33208
OrthoFinder	1	1.000	-	-		FOG0007196
OrthoInspector	1	1.000	-	-		oto39036
orthoMCL	1	0.900	-	-		OOG6_107971
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820