DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and ush2a

DIOPT Version :9

Sequence 1:NP_001286474.1 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:XP_009291422.1 Gene:ush2a / 568982 ZFINID:ZDB-GENE-060503-794 Length:5243 Species:Danio rerio


Alignment Length:1570 Identity:290/1570 - (18%)
Similarity:488/1570 - (31%) Gaps:534/1570 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 FQGHCGHTSPCEQLCYEIHDGMYECD-CIEGYE-LNKNGY-SC------------QVINATSNSL 92
            |.|.| |....:.||.....| .:|| |:||.. ::.|.| .|            :|:|:|:..|
Zfish  1024 FNGTC-HPQTGQCLCKPFVTG-DKCDACVEGASFMDPNNYLGCSKDPQQQPPPLGRVLNSTTIEL 1086

  Fly    93 DGRGKS-------------DEDVLYQKGAS------------------FSAKLANDDGGKSMAKS 126
            ..|...             |..:::...:.                  :|.:|...:...:.:.|
Zfish  1087 SWRTPDSPNSNALMYTLLRDTQIIHVSHSQHPFGTMHFIDTALSPYTLYSYQLITSNIRSNTSSS 1151

  Fly   127 TFALSAAQSASPAGNE----------------NGEDESGSEG--DSYDYGELEDSNSE------- 166
            ...|... ||.|...|                |..:...:.|  |:|....::|.:.|       
Zfish  1152 VVTLRTL-SAVPEQEELQLTLVGRAKPNSASFNWTEPLNTTGPIDNYTLSSIQDLSGEKRIYYTG 1215

  Fly   167 -----TQEQKQ--------------------KSLNLQ-----QQQQQQQKVNS------------ 189
                 |.|:.|                    :||.:|     .:||...|:.:            
Zfish  1216 LQTEATAEELQPFTRYNFSLKACTDGGCARSESLVVQTAQIPPEQQPAPKITTLGSSQLKVDWEP 1280

  Fly   190 ----NDYYISAE-------SINFNSESEGQEQQDVADFKAASTMLPSS-VPPTPSRSTTRATAST 242
                |...|..|       .:..|:.|.|.||:         ..|.|. :.|.||.|:....|.|
Zfish  1281 PVLPNGIIIRYELFMQLLNELQRNASSYGTEQR---------VFLSSGWLNPRPSLSSANENALT 1336

  Fly   243 --TTTTTTTRRSPTRAPKQRVDV---------DYGEG---DGSDDY----------------SYS 277
              .:|...:...|....:.||..         |:..|   :|..:|                |:.
Zfish  1337 PPESTVVVSNLQPFSTYRFRVLTVNMAGSVLSDWAVGRTAEGVPEYMAPPQVSAVSSSSLRVSWE 1401

  Fly   278 YKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYPNVT----SNKVQMHITRETNRL 338
            ...|..|..:|...::||.:...|..|..             |.||    |...|.|    :...
Zfish  1402 TPRDKDVRGEVTEYRVNLHQEQMSNPYAP-------------PIVTQVLYSGSAQEH----SYTA 1449

  Fly   339 ENISAAE-----------PAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTG- 391
            ..:.|.|           ...|.::..:.|:.|:......:.|:..|..||.:.....|....| 
Zfish  1450 GGLKAYEEYSFTVTVCNRQGCVSSSPASGRTLPSAPAGLRAPGLRPLNMTAMNVFWDAPAELNGP 1514

  Fly   392 ---------NGCQEDIRAHV---PRFAKRSWLAFPA----LHGAYKHVQLRIEFRPESFDGIILL 440
                     :....|.:..|   .||....:..||:    ::..:..:||  .||..:.:|::|.
Zfish  1515 PPLYHVERTDVSLSDAQGQVIRGRRFTGSGFFRFPSATLPVNADFTGLQL--SFRTRAEEGLLLF 1577

  Fly   441 S---GERDDLTGDFMALLLNKGFVEFWFDCGSGV--------GSVRSRETILLNEWNSVIIYRHR 494
            :   ||::    :::||.::.|...|.||..:..        |..|..:    |:|:.:|..|.:
Zfish  1578 AVSPGEQE----EYVALQIHNGRPYFLFDPQASAVALSPRNDGGRRYND----NQWHHLIATRKQ 1634

  Fly   495 WDAWLVLNH----------GTKVQGRSNGLFSRITFREPVFLGGI-GNIT------GLAKRLPLA 542
            ....:::::          |:.:.|::.|          ||:||| .|.|      |.||.  :.
Zfish  1635 AVGTIIVDNQYSGSASATSGSTIIGQNTG----------VFIGGIPENFTILRQDAGQAKL--VQ 1687

  Fly   543 EGFAGCIRRFV------ANEHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGA 601
            :|||||:|..:      |||     ...|| |..:..:..:       .|....|...: |:.||
Zfish  1688 QGFAGCLRDVLVQKSSGANE-----AWEPL-DWESALETHE-------TYESWEGCPAV-SENGA 1738

  Fly   602 ICLCPIGFVGDLCEIRMDLQVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEH 666
            .                      |.|..||:..|...:...:.|:....|.:|.:.|:|::....
Zfish  1739 Y----------------------FLGHGFLKVKPEILTGGNYFEISFEFKTDQLNALLLFAYDID 1781

  Fly   667 RGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSL----------GQWHTIKISRTARLAVLKVD 721
            ..|||...|..|.:.:....|        |.::.|          |.|:|:.:.:...||...::
Zfish  1782 GKDFILAELQGGVLFWVLRWG--------EQTVELSVWVGLSYCDGGWNTLSVLKRGHLASAGLN 1838

  Fly   722 KHQE--------VLTISSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYKPF--FVGCIQRIDI-NG 775
            ...|        .|||||          .|::|||......|...|:...  |.|||:.:.: .|
Zfish  1839 DMYEQERKAIGGPLTISS----------PLYIGGVPPGVTHPALNKHSLLHGFGGCIRDVRLARG 1893

  Fly   776 HSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESYECRCS----IHNERCNKAAEVPPEQ 836
            ..:.:.|.:.....:.             |..|:....|..||.:    ::..|...|.::..:.
Zfish  1894 PVVSLAAVSSSAVRVN-------------LDGCLSADTSVNCRGNDSILVYTGRDRSAEDLTLQP 1945

  Fly   837 LPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSE 901
            ..|   :..:|:.:.:.|    .:.|...:..|::                    |...:..|..
Zfish  1946 FTE---YLYRVMASGEGG----WIGGPWQRGRSRE--------------------TVPQSVLPPS 1983

  Fly   902 RTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKH 966
            |     .|:::...:|        ...::..|::...::....|.:....||.|..|        
Zfish  1984 R-----VGSVNGSSVE--------VSWEEPAEVRGVIEKYVLKAYSRDRPSSSPISA-------- 2027

  Fly   967 HASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAASQVP 1031
             ...|..||                     |...|.:..|...:..:|:..|      ...|:.|
Zfish  2028 -TFPHSQHL---------------------TGTLSGLAPFSSYSITLTACTQ------AGCSESP 2064

  Fly  1032 LAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKA 1096
            .|   ....||:.:........|..:..||                          :.|.:|   
Zfish  2065 FA---TGFNTPQEAPEEVPPPAAVSYPNSL--------------------------SVHWNH--- 2097

  Fly  1097 EVQFPPQGS----QEVGTANEDTSQY---SDDYNDDE---------LLTPVMQGG--EEVKLEQH 1143
                ||:.:    |.:...| :|..|   |..:|..:         ||:...:.|  ...::...
Zfish  2098 ----PPKPNGIIIQYILYKN-NTVLYRGNSTSFNITDVGVFTPHKLLLSACTEAGCTNSTQVTLF 2157

  Fly  1144 TSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACF-------AGSDSYFHYNDAD-----TM 1196
            |...|.|:.:..:|...|..:.|......|..|....|       .|.:....||.::     |:
Zfish  2158 TGQLPPTYVEPPILTVLDARSIHIQWAAPVEVNGLLEFYTLHQWALGEEPLIVYNSSELFQDYTV 2222

  Fly  1197 SQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHD-------DYLSLGIEQGYLHFRYDLGSGE 1254
            ..::..|..| .:|...:..|..|.......|||..       :.|||....  ||.     |..
Zfish  2223 RNLVPGSTYL-FQIAACTGGGCTLSDPSTARTEESSPEEVPAPNILSLSPHS--LHL-----SWT 2279

  Fly  1255 VDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLR-QLNTDTGLYVG------- 1311
            ...:.||...|.|||.....::||.....||......:|.:   .| |..|..|..:|       
Zfish  2280 PPRKPNGVISSYGLWMDGTLVQNSSLMASEVGDLSPWSLHS---FRVQACTAQGCALGPLVESRT 2341

  Fly  1312 -GMPDVGYFT 1320
             .||.||:.|
Zfish  2342 LEMPPVGHVT 2351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_001286474.1 FXa_inhibition 53..82 CDD:291342 10/31 (32%)
LamG 404..555 CDD:238058 43/188 (23%)
EGF 583..612 CDD:278437 5/28 (18%)
LamG 625..774 CDD:238058 39/169 (23%)
LamG 1205..1340 CDD:214598 34/132 (26%)
ush2aXP_009291422.1 Laminin_G_3 160..297 CDD:290121
Laminin_N 307..528 CDD:295486
EGF_Lam 529..577 CDD:238012
EGF_Lam 586..638 CDD:238012
Laminin_EGF 653..703 CDD:278482
Laminin_EGF 706..756 CDD:278482
EGF_Lam 759..797 CDD:214543
Laminin_EGF 808..857 CDD:278482
EGF_Lam 859..912 CDD:238012
EGF_Lam 913..963 CDD:238012
EGF_Lam 965..1014 CDD:238012
EGF_Lam 1015..1064 CDD:238012 14/41 (34%)
FN3 1177..1253 CDD:238020 11/75 (15%)
FN3 1264..1375 CDD:238020 23/119 (19%)
FN3 1386..1469 CDD:214495 16/99 (16%)
LamG 1537..1699 CDD:238058 43/183 (23%)
LamG 1737..1890 CDD:238058 41/192 (21%)
FN3 1981..2071 CDD:238020 21/141 (15%)
FN3 2163..2253 CDD:238020 16/90 (18%)
FN3 2258..2341 CDD:238020 22/92 (24%)
FN3 2352..2443 CDD:238020 290/1570 (18%)
FN3 2447..2544 CDD:238020
FN3 2547..2633 CDD:238020
FN3 2635..2733 CDD:238020
FN3 2743..2807 CDD:238020
FN3 2830..2932 CDD:238020
fn3 2939..3014 CDD:278470
FN3 3032..>3099 CDD:238020
FN3 3542..3611 CDD:238020
FN3 3615..3701 CDD:238020
fn3 3718..3784 CDD:278470
FN3 3801..3887 CDD:238020
FN3 3908..3971 CDD:238020
FN3 3996..4086 CDD:238020
FN3 4186..4284 CDD:238020
fn3 4288..4366 CDD:278470
FN3 4382..4465 CDD:238020
FN3 4470..4553 CDD:238020
FN3 4555..4653 CDD:238020
FN3 4679..4753 CDD:238020
fn3 4760..4830 CDD:278470
FN3 4864..4955 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3509
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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