DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP2353 and hspg2

DIOPT Version :9

Sequence 1:	NP_001286474.1	Gene:	SP2353 / 36771	FlyBaseID:	FBgn0034070	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_021325650.1	Gene:	hspg2 / 565429	ZFINID:	ZDB-GENE-080807-4	Length:	3701	Species:	Danio rerio

Alignment Length:	1418	Identity:	308/1418 - (21%)
Similarity:	486/1418 - (34%)	Gaps:	469/1418 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSASIAVGAIPEPEEAAFQGHC-GHTSPCEQLCYE---IHDGMYECDCIEGYELNKN-------- 78
            :..|:.||.:       .:..| .|.:|  .|.||   |:..:.....::|.:|..|
Zfish  2617 NDVSVRVGEV-------IRLQCLAHGTP--PLRYEWTKINGSLPSTAQLQGGDLQINLAKENDAG 2672

  Fly    79 GYSCQVINATSNSLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASPAGNEN 143
            .|.|    ..||.:   |||:........:|.|.|::.....|::..:.....||:     |...
Zfish  2673 TYRC----VASNKV---GKSEALAKVSVRSSLSVKVSPQVEVKALGSAVEFTCAAK-----GGLQ 2725

  Fly   144 GE--DESGSEGDSYDYGE-------LEDSN--------SETQEQKQKSLNLQQQQQQQQKVN--- 188
            .|  .|.|....::...:       ||.||        :...|..|.|..|..|...:.|:|
Zfish  2726 IEWLKEGGVLPPNHHIKDGILRIENLEQSNEGIYTCRVTSQFEHAQDSAKLLIQALPKVKINVRT 2790

  Fly   189 SNDYYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPPTPSRSTTRATASTTTTTTTTRRSP 253
            |....:...|:.|...:.|..:..|...|..:        |.|.....|...
Zfish  2791 SVQTVMVGNSVEFECHAIGDPEPTVRWSKVGA--------PLPDHVEIRGNI------------- 2834

  Fly   254 TRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRR--------NSKSQTYQQTSNT 310
                 .|:|..:    .||...|...:...|..:.::..||::.        .||..|....:..
Zfish  2835 -----LRIDQVF----ESDSGQYRCTATNDVGSEHSHVVLNIQSLPQIAALPESKEVTIGSDAVL 2890

  Fly   311 NTAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTCNLDCGSDGICALE 375
            ....:....|.:|.:||:..:..:. |.:..:...|.|.    .:|..|..|
Zfish  2891 PCIASGYPVPTITWSKVENDLPPKC-RQDGHALTVPVVT----ESDAGTYVC------------- 2937

  Fly   376 ATAASSRCLCPFGKTGNGCQEDIRAHV-PRFAKR--SWLAFPALHGAYKHVQLRIEFRPESFDGI 437
             |||:.:     ||.....:.::...| |.|.:.  |:|..|.:..:||...::|.|||::.||:
Zfish  2938 -TAANKQ-----GKVEAFTRLNVHERVMPYFTQEPLSYLTLPTIKNSYKAFSIKITFRPDNVDGL 2996

  Fly   438 IL------LSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWD 496
            ||      .:|::.....||::..|..|..||.||.|||:.::|....|.|.|:::|.:||::..
Zfish  2997 ILYAGMIIYNGQKKTTGADFISFGLLGGRPEFRFDVGSGMATIRYPTPIKLGEFHTVHLYRNQTQ 3061

  Fly   497 AWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKF 561
            ..||::....|.|.|.|.|..:...|.:|:||..|.:.|||...|..||.|||::.:....:..|
Zfish  3062 GSLVVDGQAPVNGTSQGKFKGLDLNEELFVGGYPNYSMLAKTAGLKTGFVGCIKQLIIQGDEVIF 3126

  Fly   562 TEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKC-------------------------------- 594
            .:  |.....|  :.:|.|  |...|||:.|.|
Zfish  3127 KD--LDKSSTG--VSNCPT--CKDRPCQNDGTCEDSVASLYKCTCKRGFTGSNCQHHSSLHCHTE 3185

  Fly   595 ----------LPSDQGAICLCPIGFVGDLCEIRMD---LQVPAFNG-SSFLRYAPL----GDSAL 641
                      .||..|..|.|.:|..|:.|   ||   :..|.|:| .|::.|.||    .|
Zfish  3186 ACGPDATCINRPSGLGYDCRCHLGKSGNKC---MDGTLITTPLFDGEDSYIAYPPLTNIHND--- 3244

  Fly   642 IWLELKVTLKPEQADGLILYSGPEHR--GDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQW 704
              |.:::..||...|||:.:||.:..  .||:|:.:.:|.|||.::||:|.|::||:..:||.||
Zfish  3245 --LRIEMEFKPMDPDGLMFFSGGKKMKVEDFVAVSMVNGHVEFRYELGTGQAVLRSQEPVSLDQW 3307

  Fly   705 HTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQ 769
            |.:...|..:...|.||..:|:...|......|::...:::|||..:|.||........|.|||.
Zfish  3308 HRVVAERLNKDGSLTVDHAKEITRSSPGKAQGLNIHTPMYLGGVPSMDILPKPANVSMLFDGCIG 3372

  Fly   770 RIDINGHSLGIVAEALGGSNIGNC--PHACVARPCGPLAECVPQME-SYECRCS--IHNERCNKA 829
            .:.|||..:.:.........|..|  ...|..|||.....|:...| .|:|.|:  ...:||
Zfish  3373 EVFINGKKVDLSYSFTESRAISQCNDDSPCDRRPCLHAGTCMATAEYEYQCFCAEGYEGDRC--- 3434

  Fly   830 AEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTT 894
                 |.:.|...|.|:.    .||.:..               |.|...||
Zfish  3435 -----EIVKESCRHSSQC----QNGGSCV---------------NNHCVCPA------------- 3462

  Fly   895 TTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAK 959
                           ..|....|                   :.|:::.:....|...||.:.:
Zfish  3463 ---------------GYSGRHCE-------------------KGQESSFSEAMWSLEGSGGNDS- 3492

  Fly   960 PRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDA 1024
                                         |..|.::          |.||              .
Zfish  3493 -----------------------------PIEYSAY----------FHDN--------------G 3504

  Fly  1025 MAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNA 1089
            ..|...|: |..::|.:|
Zfish  3505 YLALPKPM-FPRSAPDSP----------------------------------------------- 3521

  Fly  1090 HSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDW 1154
                                                          |.::||.:|:|     .|.
Zfish  3522 ----------------------------------------------ETIELEINTAS-----KDG 3535

  Fly  1155 SLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVI 1219
            .:|            .|||..      ||:                     |||    |.::..|
Zfish  3536 LIL------------WQGVES------AGA---------------------LNL----HKKHANI 3557

  Fly  1220 LWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLE 1284
            ...|.||   :..|::|||::.|:|.|.|.|||||..| .:|..|:|..||::.|:|..:.|||:
Zfish  3558 KELGDQG---KGKDFISLGLQNGHLVFSYQLGSGEAQI-VSGEPVNDRQWHKITAVRTGKHGYLQ 3618

  Fly  1285 VDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVL 1337
            :||......::.||...:||...:|:||.||:...|..:|.||:.||:..:.|
Zfish  3619 IDGGSVQRGQSQGKSIMVNTKGNIYLGGAPDMQALTGGKYSSGMTGCVKNLSL 3671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_001286474.1	FXa_inhibition	53..82	CDD:291342	8/39 (21%)
		LamG	404..555	CDD:238058	54/158 (34%)
		EGF	583..612	CDD:278437	12/70 (17%)
		LamG	625..774	CDD:238058	50/155 (32%)
		LamG	1205..1340	CDD:214598	50/133 (38%)
hspg2	XP_021325650.1	SEA	84..198	CDD:321958
		LDLa	216..251	CDD:238060
		LDLa	277..311	CDD:238060
		LDLa	317..351	CDD:238060
		LDLa	360..395	CDD:238060
		Ig_Perlecan_like	413..490	CDD:143220
		Laminin_B	598..732	CDD:306547
		EGF_Lam	766..814	CDD:238012
		EGF_Lam	831..869	CDD:238012
		Laminin_EGF	871..923	CDD:278482
		Laminin_B	991..1125	CDD:306547
		Laminin_EGF	1159..1206	CDD:278482
		EGF_Lam	1208..1261	CDD:238012
		Laminin_EGF	1272..1315	CDD:278482
		Laminin_B	1536..1671	CDD:306547
		EGF_Lam	1705..1754	CDD:238012
		EGF_Lam	1755..1811	CDD:238012
		IG_like	1823..1903	CDD:214653
		Ig_Perlecan_like	1911..1996	CDD:143231
		I-set	2025..2109	CDD:254352
		I-set	2119..2231	CDD:254352
		I-set	2241..2309	CDD:333254
		Ig_3	2333..2407	CDD:316449
		Ig_3	2427..2500	CDD:316449
		I-set	2517..2606	CDD:254352
		I-set	2610..2693	CDD:333254	20/91 (22%)
		I-set	2699..2778	CDD:333254	16/83 (19%)
		I-set	2785..2867	CDD:254352	18/111 (16%)
		I-set	2871..2954	CDD:254352	18/106 (17%)
		LamG	2961..3119	CDD:238058	54/157 (34%)
		EGF_CA	<3146..3175	CDD:238011	5/28 (18%)
		LamG	3226..3377	CDD:238058	50/155 (32%)
		EGF	3402..3433	CDD:306513	9/30 (30%)
		EGF_CA	3441..3470	CDD:238011	9/75 (12%)
		LamG	3497..3671	CDD:238058	69/343 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17288at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920