DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SP2353 and agrn

DIOPT Version :9

Sequence 1:NP_001286474.1 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:XP_021325504.1 Gene:agrn / 565373 ZFINID:ZDB-GENE-030131-1033 Length:2056 Species:Danio rerio


Alignment Length:1400 Identity:285/1400 - (20%)
Similarity:479/1400 - (34%) Gaps:526/1400 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 SSASIAVGAIPEPEEAAFQGHCGHTSPCEQLCYEIHDGMYECDCIEGYELNKNGYSCQVINATSN 90
            |..:.|.|..|:.:.||.... |...|....    ..|....|.:||.|:   .|:.::.:..|.
Zfish  1101 SCDNTAFGCCPDGKTAAVNSE-GTNCPSTMR----FSGFLHLDKVEGQEV---FYTPEMEDPKSE 1157

  Fly    91 SLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASPAGNENGEDESGSEGDS- 154
            ......:|.|..:            |:...||..:..|.....::.||:.:.....|:..:.|: 
Zfish  1158 LFGETARSIESAM------------NELFRKSDVQKDFQSVRVRNLSPSNSIIAHFEAHFDPDTR 1210

  Fly   155 YDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNSNDYYISAESINFNSESEGQEQQDVADFKAA 219
            ::.|::|.:..: |.:..|...:..::.:::.:..|:|.:                         
Zfish  1211 FNVGDIEGALLK-QLKASKDTGIVVKKPEEENIRINNYGL------------------------- 1249

  Fly   220 STMLPSSVPPTPSRSTTRATASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSV 284
                 |:||...:.:||.|:.:|.|||||| .||:.|                   |:       
Zfish  1250 -----STVPFFTTTTTTVASVTTPTTTTTT-MSPSSA-------------------YT------- 1282

  Fly   285 YDDVNNNQLNLRRNSKSQTYQQTSN----TNTAKNRRKYPNVTSNKVQMHITRETNRLENISAAE 345
                     .||..:..:.:.:|:.    |.||      |:|....|.:     .|||       
Zfish  1283 ---------TLRPITTRRPFTRTTTPAPATTTA------PHVPKTTVSL-----MNRL------- 1320

  Fly   346 PAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSW 410
                    .....:|..:..|...|.|  |.......|:||.|:.|..|::.|:..:|.|..:|:
Zfish  1321 --------GPHAHSPCDSQPCRHGGTC--EEDDNDFTCICPAGRGGAVCEKVIKYFIPSFGGKSY 1375

  Fly   411 LAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVR 475
            :||..:. ||..|::.:|||.....||:|.:|::.  ..||::|.|.:|:||..|:.|||..||.
Zfish  1376 MAFQTMK-AYHTVRIAMEFRASEMTGILLYNGQKS--KKDFLSLTLVEGYVELRFNTGSGTASVI 1437

  Fly   476 SRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGI--GNITGLAKR 538
            |:..:....|:.:::.|:|.:|.|.:::...|:|:|......:.....:|:||:  .....:.:|
Zfish  1438 SKVLVKPGRWHQLVVVRNRRNAMLSVDNEPSVEGQSPPGTDGLNLDTDLFIGGVLDDMSADVKER 1502

  Fly   539 LPLAEGFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKC--------- 594
            ..::.|..||||....|...|...|:. |.|:.|..|.:|..:.|:..||::|..|         
Zfish  1503 TSVSAGLVGCIRMLDVNNLVYNLQENG-GSVLYGSAIGECGNNPCLPNPCKNGASCQVKEAEIFH 1566

  Fly   595 --------------------------------LPSDQGAICLCPIGFVGDLCEIRMDLQVPAFNG 627
                                            || :.|..|.||:|..|..||...|      .|
Zfish  1567 CKCVNGFSGPTCADAHNPCDPNKCHPPSRCQVLP-EGGYKCECPMGREGRHCEKVSD------KG 1624

  Fly   628 SSFLRYAPLGDSALIWLELK----------------VTLKPEQADGLILYSG--PEHRGDFIALY 674
            .:|:.|. .|||   :||||                :.|....:.|:|.|:|  .:.:||||:|.
Zfish  1625 GAFIPYF-TGDS---FLELKGLHTYNQDLRQKFSMTIVLLANDSKGMIFYNGQKTDGKGDFISLS 1685

  Fly   675 LNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQ----EVLTISSNGFW 735
            ||||.:||.:|||.|||::||:..:.|.:|:|:.:.|.:|...:.::...    |......|...
Zfish  1686 LNDGILEFRYDLGKGPAVIRSKEKIKLNEWNTVNLERASRKGEISINGKDPVRGEAPKSRKNQHT 1750

  Fly   736 HLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCP-HACVA 799
            .|:|.::|||||.....::......|..|.|.||:|.:.|..:.....||..:::...| |.|..
Zfish  1751 DLNLKESLFVGGAPDFRKVARAAAIKDGFKGAIQKITLMGIPILKADNALSSTDVSMYPNHPCSK 1815

  Fly   800 RPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLA 864
            ..|.....|.||:.||||.|                                             
Zfish  1816 DVCENGGRCNPQLNSYECAC--------------------------------------------- 1835

  Fly   865 HKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQ 929
                  :|                                     ..|....:|.|..:      
Zfish  1836 ------RH-------------------------------------GFSGHHCQDTIFEK------ 1851

  Fly   930 QQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYES 994
                                  |:|                                        
Zfish  1852 ----------------------SAG---------------------------------------- 1854

  Fly   995 FQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDE 1059
                 |::.:.| |.:.::      ||.:.:..||:.....|                     .|
Zfish  1855 -----DTEAIAF-DGHTFI------EYHNGVTKSQLTNEIPD---------------------PE 1886

  Fly  1060 SLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYND 1124
            ||.:.||.:|    |.|                                                
Zfish  1887 SLENPSDQSE----KAL------------------------------------------------ 1899

  Fly  1125 DELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFH 1189
                                           |:.||:||                          
Zfish  1900 -------------------------------LVNKFELS-------------------------- 1907

  Fly  1190 YNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGE 1254
                                |:|.:.:|:|||:|: |.  |..||::|.|..|.:...|||||..
Zfish  1908 --------------------IRTEATHGLILWSGK-GV--ERSDYIALAIVDGRVQMTYDLGSKP 1949

  Fly  1255 VDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYF 1319
            |.:| :..:|:...|.|::|.|..::|.|:|.....||..:|....||:||..|::||:.::...
Zfish  1950 VVLR-STVRVNTNHWIRIKASRALRDGSLQVGNEAAVTGSSPLAATQLDTDGALWLGGLEELSVA 2013

  Fly  1320 TH--QRYFSGIVGCISEIVLAGEMKLNFDPNTLGT 1352
            ..  :.|.:|.:||:.::::.| ::|:...:.|.|
Zfish  2014 RRLPKAYSTGFIGCVKDVIVDG-VELHLVEDALNT 2047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_001286474.1 FXa_inhibition 53..82 CDD:291342 6/28 (21%)
LamG 404..555 CDD:238058 45/152 (30%)
EGF 583..612 CDD:278437 12/69 (17%)
LamG 625..774 CDD:238058 54/170 (32%)
LamG 1205..1340 CDD:214598 43/136 (32%)
agrnXP_021325504.1 NtA 43..146 CDD:308653
KAZAL 200..246 CDD:197624
KAZAL 276..321 CDD:197624
KAZAL_FS 353..393 CDD:238052
KAZAL 422..465 CDD:197624
KAZAL 494..539 CDD:197624
KAZAL 561..606 CDD:197624
KAZAL 626..671 CDD:197624
KAZAL 709..755 CDD:197624
Laminin_EGF 798..840 CDD:278482
Laminin_EGF 852..>888 CDD:278482
KAZAL 932..974 CDD:197624
SEA 1145..1228 CDD:307516 15/98 (15%)
EGF 1328..1356 CDD:306513 8/29 (28%)
LamG 1369..1519 CDD:238058 45/152 (30%)
Laminin_G_1 1663..1794 CDD:278483 44/130 (34%)
EGF_CA 1814..1845 CDD:238011 11/118 (9%)
Laminin_G_1 1908..2039 CDD:278483 44/135 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3509
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.