Protein Alignment SP2353 and lamb2l

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_692838.6
• Gene: lamb2l / 553337
• ZFINID: ZDB-GENE-030131-4205
• Length: 1836
• Species: Danio rerio
• Alignment Length: 734
• Identity: 134/734 - (18%)
• Similarity: 237/734 - (32%)
• Gaps: 210/734 - (28%)

  Fly   564 HPLGDVINGFDIQDC--STDKCVRYPCQHGGKCLPSDQGAICLCPIGFVGD-------------- 612
            ||||.     :...|  :|..||   |:.|......|:     |..||.|:
Zfish  1178 HPLGS-----ETSQCDRTTGACV---CKDGASGQRCDE-----CARGFTGNFPKCVPCHPCFQLW 1229

  Fly   613 ---LCEIRMDL--------------QVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLIL 660
               :|::|.||              :||.           :.|..::.||.|:.    ||..|:.
Zfish  1230 DDVVCQVRRDLTHFRDIIAMILEKGEVPG-----------VSDKRILELEKKLA----QAQELVR 1279

  Fly   661 YSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVR-----SEHSLSLGQ---------------WH 705
            ....|...:.|:..::|...|.|...|....::|     ::|:..|.|               .|
Zfish  1280 DGDREGTFNLISQTVDDLRAEIALTDGRLMGVIRDLNVTTDHNNDLKQNLTALEKELKDLNNTLH 1344

  Fly   706 TIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQ----NLFVGGV-----------NHVDRLP 755
            .::......|.....::...||.     ::..||:.    |..|.|.           |..:.|.
Zfish  1345 QLRRELENYLTAGLAEQFANVLK-----YYQRSLNSEQRCNASVYGPQSPVEQSQDTRNRTEALL 1404

  Fly   756 LDLKYKPFFVGCIQRIDINGHSLG---------------IVAEALGGSNIGNCPHACVARPCGPL 805
            .|.|     ...::....|..||.               :..:..||...||...:|...|||.
Zfish  1405 KDKK-----DSLLRTATANNKSLSELEGKAHEINRKVHHLSNKVCGGHANGNVNGSCEESPCGG- 1463

  Fly   806 AEC-----VPQMESYECRCSI--------HNERCNKAAEVPPEQLPELALH-----------KSK 846
            |.|     |.:.....|..::        :.:..:|......|:|..:|..           |::
Zfish  1464 AGCRGSDGVLKCGGRGCNGTVGASVKALDNADEVHKNLTAVSEELQTMAKKLRDIATLTQTVKTQ 1528

  Fly   847 VLETKDNGEAAKKV---SGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATA 908
            ..||.|..:..|.:   |....|...:|.::......|...:....:........|..||
Zfish  1529 AKETLDKAQNKKDMFEKSNKMLKNFIQKIKDFLNEEGADPESIEKVAQQVLAISLPVNRT----- 1588

  Fly   909 GALSN--EEIEDDI--------IFRLVQQQ-QQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRL 962
             .:.|  |:|:|.|        :|....:| .:..:|.|:.|...|.|..   .|...:|.|..|
Zfish  1589 -VIVNLVEQIKDSIVNLTNVEGVFNHTSEQLAKVNDLLKKAQDAKTQADG---VSDNINKTKEAL 1649

  Fly   963 SGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAA 1027
            ....:|.|     |.....:..|..| .:.::.....|..:|..::|                 .
Zfish  1650 ETSQNAIK-----KAEEEMSTALKNL-KNIQNITAMVDDKLLNLDNN-----------------L 1691

  Fly  1028 SQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSS 1092
            :.|.:...:.|.|....  .|:.::|..:..|:...:.:.|.|      |:.::..:  :||.:.
Zfish  1692 TDVMMRLVNLSNGVDLL--KNKTEQNREMAKEAKAQSDNATRE------AEGLQEEL--TNAETL 1746

  Fly  1093 HKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEV-KLEQHTSSTPQTHTDWSL 1156
            :|:.:.:....|....|..|:...:...:..|  ||.....|.|.: |||:..:...|     .:
Zfish  1747 YKQLKEKVDSAGGTGEGNVNQKAIEMKKEAED--LLKKATMGMETLKKLERKFNKNEQ-----KM 1804

  Fly  1157 LKKFDLSAEHQSQVQGVRK 1175
            .::.|...:.:..|.|:|:
Zfish  1805 QQQRDELTDLEKNVTGIRE 1823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251
		LamG	404..555	CDD:238058
		EGF	583..612	CDD:394967	8/28 (29%)
		LamG	625..774	CDD:238058	30/183 (16%)
		LamG	1205..1340	CDD:214598
lamb2l	XP_692838.6	Laminin_N	32..266	CDD:459653
		EGF_Lam	267..320	CDD:238012
		EGF_Lam	332..384	CDD:238012
		Laminin_EGF	395..452	CDD:395007
		EGF_Lam	454..505	CDD:238012
		EGF_Lam	506..>545	CDD:238012
		EGF_Lam	816..861	CDD:214543
		Laminin_EGF	864..912	CDD:395007
		EGF_Lam	910..954	CDD:238012
		Laminin_EGF	960..1016	CDD:395007
		Laminin_EGF	1019..1063	CDD:395007
		Laminin_EGF	<1089..1129	CDD:395007
		EGF_Lam	1126..1168	CDD:238012
		Laminin_EGF	1175..1215	CDD:395007	14/49 (29%)
		COG4372	1245..>1436	CDD:443500	35/215 (16%)
		Mplasa_alph_rch	1492..>1818	CDD:275316	65/374 (17%)
		cc_LAMB_C	1766..1835	CDD:411969	14/65 (22%)