DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and wb

DIOPT Version :9

Sequence 1:NP_001286474.1 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:1519 Identity:277/1519 - (18%)
Similarity:503/1519 - (33%) Gaps:407/1519 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 VLSSLSSASIAVGAIPEPEEAAFQGHCGHTSPCEQLCYEIHDGMYECDCIEGYELNKNGYSCQV- 84
            ||..:.:.||.||...:..:...|....|..|          |..|    :|..|.:.....|: 
  Fly  2044 VLEHVRNLSIRVGESHQELDELNQRISDHLDP----------GYLE----QGEGLLRLTVQRQIM 2094

  Fly    85 INATSNSLDG-------------------------RGKSDEDVLYQKGASFSAKLANDDGGKSMA 124
            :|...|.|||                         :.:.....|..:...::.|......|..:|
  Fly  2095 LNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIA 2159

  Fly   125 --------KSTFALSAAQSASPAGNEN----------GEDESGSEGDSYDYGELEDSNSETQEQK 171
                    ..|.|::.|:.||....|.          .:..|..|...:.....:....|..:|.
  Fly  2160 MLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQM 2224

  Fly   172 QKSL----NLQQQQQQQQKVNSNDYYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPPTPS 232
            .||.    .|.:|:||.:.:.|..|.....:.|.:.:.:|.                       |
  Fly  2225 HKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGL-----------------------S 2266

  Fly   233 RSTTRATASTTTTTTTTRRSPTRAPKQRV-DVDYGEGDGSDDYS-----YSYKSDMSVYDDVNNN 291
            ..:.|..|..:...........||..|:. |:.....:..:.:|     :..|..|: .::::..
  Fly  2267 DGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMA-QENISLT 2330

  Fly   292 QLNLRRNSKSQTYQQTSNTNTAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTD 356
            |.|||..:.|.:|.:    ..|:..::...|.:|.:...:.:   ..:.|:.|..|.....::.:
  Fly  2331 QTNLRLANVSLSYLE----QQAEKEQQVFEVWNNSMAQQLQQ---LRDQIAKARHAAEAIDVSLE 2388

  Fly   357 RSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYK 421
            ...|.|                                   ||:::           ||.:|...
  Fly  2389 SLGPKC-----------------------------------IRSYL-----------PASYGLST 2407

  Fly   422 HVQLRIEF----RPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGS------VRS 476
            ..::|:.|    ..||...|.|.|.|     |..:.|.|.|..|...::.|....:      |.:
  Fly  2408 SNKIRMSFALSNHLESSPLIHLASSE-----GRHITLELYKRRVRLVWNLGGTTATVTHPMVVHT 2467

  Fly   477 RETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGN------ITGL 535
            |:....:.|..|       :|...||.|:.|..|.|. :..:|...||.:.|..:      ....
  Fly  2468 RDPKYDDAWYHV-------EANRTLNLGSLVVRRMNN-YGELTPPNPVIITGSTDTEHTRFYQSR 2524

  Fly   536 AKRLPLAEGFAGCIRRFVAN----EHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLP 596
            :.|:.|. |||....:|...    .|..:....|||       :.:..|.:         |.|..
  Fly  2525 SDRISLG-GFASKDLQFTPGLNVVVHQVEVDNKPLG-------LWNFVTSE---------GSCGG 2572

  Fly   597 SDQGAICLCPIGFVGDLCEIRMDLQVPAFNGSSFLRYAPL-----GDSALIWLELKVTLKPEQAD 656
            |..||            .|.........|||   |.||.|     ..:......:::|.:....:
  Fly  2573 SMVGA------------KESSASSTARHFNG---LGYAQLMKTRPRPTRKNLFSVQMTFRTLDEN 2622

  Fly   657 GLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPAL-VRSEHSLSLGQWHTIKI--------SRT 712
            .|:..:..:.....:::.|:.|.:.|..|.|....| :.:....::|||  |||        .|:
  Fly  2623 ALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQW--IKIEAAREFSAKRS 2685

  Fly   713 ARLAVLKVDKHQEVL---TISSNGFWHLSLDQN---LFVGGV-----NHVDRLP-LDLKYKPFFV 765
            ....:|:|:..:.:.   |:..|  .||..|.:   .::|||     :...:.| .|   .| |:
  Fly  2686 TENGMLRVNNDRPISGAPTLPVN--IHLLPDLSKTVYYLGGVPPGFTSGTSKAPGAD---NP-FL 2744

  Fly   766 GCIQRIDINGHSLGIVAEALGGSNIGNCPHAC--VARPCGPLAECVPQMESYECRCSIHNERCNK 828
            ||::.:.:||.:.    :.|..|:......:|  :....|.......::.|...|     :|.|.
  Fly  2745 GCMKDVQVNGETY----DPLESSSYYGVEPSCKNMITKAGFSGNGYLELPSQSLR-----KRSNT 2800

  Fly   829 A---AEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTS 890
            |   ..:.|:.|..||.:..::|...|    ||.:.|  :...|.....||....:..:....:|
  Fly  2801 ALVFRTLQPDCLLLLAAYPPEILGDYD----AKDIKG--NFSISLVDGQLHVWVNSGRSFIKMSS 2859

  Fly   891 TTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGP 955
            .::...:...........|......::|::           :|::..:...|..           
  Fly  2860 NSSQMNDGEFHVVHLIKTGRKLELMVDDEL-----------QEIRNLNGNPTVV----------- 2902

  Fly   956 SKAKPRLSGKHH---ASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFED-----NNDW 1012
              :.||.:|..:   |..||.:......|......:.....:.:|...:|.|||.:     |...
  Fly  2903 --SLPRDAGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFNNRTINFNDALTFANVQIGRNGPL 2965

  Fly  1013 VTSLQQQEYGDAMAASQVPLAFED--ASPGTPRSSDNNEDDENAFVFDESLFDASD----GTEEY 1071
            :.||:...| |.:..:: |:..:.  |||...:...:...:.|||.|.:.::..|.    ....:
  Fly  2966 MGSLKGGLY-DVLLKTE-PMIGKSFTASPEGCKRIGSYSYEPNAFKFGDDIYSYSQLKLPERHFW 3028

  Fly  1072 QRK-QLAQDMKRIMSNSNAHSS--------------------------HKKAEVQFPPQ------ 1103
            ||. .|:.|.:....|...:.|                          .::.|:|...:      
  Fly  3029 QRNFHLSFDFRSFYPNGMLYLSPGSKEKPKHYVALVLKDGQLVLVVRGRRREELQLTAKLNDGEW 3093

  Fly  1104 -------------GSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWS 1155
                         .|.|:|..::.||.        ::..|...|..::.|   ....||:....|
  Fly  3094 HRVTISCHDRKVTMSVEIGRTDQKTSA--------QMKLPKKIGASQLLL---VGGLPQSPVKVS 3147

  Fly  1156 ------------LLKKFDLSAEHQSQVQ-GVRKNFGACF----AGS----DSYFHYNDADTMSQV 1199
                        .|::..::...|...: |...|.|.||    .||    |:|..|.....:.:.
  Fly  3148 SDLYVRLEPFKGCLRRVSINNNTQDLARPGKHSNVGQCFPTVERGSYFPGDAYAIYKKNFNVGKY 3212

  Fly  1200 ISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDY--LSLGIEQGYLHFRYDLGSGEVDIRFNG- 1261
                :||....:|...:|::|      :..:.:.:  |||.:..|.:.|..|.|:| ..:|... 
  Fly  3213 ----LDLETEFRTSELSGILL------SVSDPNGFPALSLELHNGNIIFSCDPGNG-APMRVESS 3266

  Fly  1262 --TK--VSDGLWHRVRAIRNSQEGYLEVDGRKTV-TLRAPGKLRQLNTDTGLYVGGMPD---VGY 1318
              ||  :.|..||.:.|:.:.::..|.:|....| ::...|...::.|.:.||:||:|:   .|.
  Fly  3267 LPTKYALCDNKWHNISALYDGEQIVLRIDQLPAVISVGNQGNAGKVQTRSPLYIGGLPESAPSGS 3331

  Fly  1319 FTHQRYFSGIVGCISEIVLAGEMK 1342
            ...:..|.   |||..:.:..|.:
  Fly  3332 LISRENFK---GCIRHVSIRNERR 3352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_001286474.1 FXa_inhibition 53..82 CDD:291342 4/28 (14%)
LamG 404..555 CDD:238058 38/166 (23%)
EGF 583..612 CDD:278437 5/28 (18%)
LamG 625..774 CDD:238058 38/174 (22%)
LamG 1205..1340 CDD:214598 35/145 (24%)
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:278482
VSP 953..1414 CDD:146106
Laminin_EGF 974..1018 CDD:278482
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:278482
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771 43/259 (17%)
Laminin_II 2277..2400 CDD:283628 23/176 (13%)
LamG 2399..>2492 CDD:304605 25/115 (22%)
Laminin_G_2 2616..2755 CDD:280389 31/146 (21%)
Laminin_G_2 2804..2944 CDD:280389 24/169 (14%)
Laminin_G_2 3038..3169 CDD:280389 16/141 (11%)
LamG 3192..3347 CDD:238058 40/168 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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