DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and LAMB2

DIOPT Version :10

Sequence 1:NP_611082.2 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:NP_002283.3 Gene:LAMB2 / 3913 HGNCID:6487 Length:1798 Species:Homo sapiens


Alignment Length:985 Identity:175/985 - (17%)
Similarity:261/985 - (26%) Gaps:374/985 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   323 TSNKVQMH----ITRETNRLENISAAEPAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRC 383
            |..:.|.|    :..:|:..|   |..|.::..:.........|  .|...|..:.|......:|
Human   743 TFERYQCHEEGLVPSKTSPSE---ACAPLLISLSTLIYNGALPC--QCNPQGSLSSECNPHGGQC 802

  Fly   384 LCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPE-------SFDGIILLS 441
            ||..|..|..|.               |..|..:|          |.|.       |.:|  .||
Human   803 LCKPGVVGRRCD---------------LCAPGYYG----------FGPTGCQACQCSHEG--ALS 840

  Fly   442 GERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTK 506
            ...:..:|..:              |.:|...:|...           ..|.:|           
Human   841 SLCEKTSGQCL--------------CRTGAFGLRCDR-----------CQRGQW----------- 869

  Fly   507 VQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHP---LG- 567
                                                 ||..| |..|.|.|..:...|.   || 
Human   870 -------------------------------------GFPSC-RPCVCNGHADECNTHTGACLGC 896

  Fly   568 -DVINGFDIQDCSTDKCV-------RYPCQHGGKCLPS---------------------DQGAIC 603
             |...|   :.|  ::|:       |.|  :||:|.|.                     .|..:|
Human   897 RDHTGG---EHC--ERCIAGFHGDPRLP--YGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVC 954

  Fly   604 LCPIGFVGDLCEIRMDLQVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGP---- 664
            .|..|:.|    :|.:...|...|..   ..|.|...|  .|....:.|...|....::|.    
Human   955 HCRAGYTG----LRCEACAPGHFGDP---SRPGGRCQL--CECSGNIDPMDPDACDPHTGQCLRC 1010

  Fly   665 -EHRGDFIALYLNDGFVEFAFD----------LGSGPALVRSEHSL----SLGQWHTI------K 708
             .|.......:...||...|..          ||:.|....|....    |.||...:      .
Human  1011 LHHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPS 1075

  Fly   709 ISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQ-----------------NLFVGGVNHVDRLPL 756
            ..|.|                  ..||:|:...                 |.|.|          
Human  1076 CDRCA------------------PNFWNLTSGHGCQPCACHPSRARGPTCNEFTG---------- 1112

  Fly   757 DLKYKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESY----EC 817
                     .|..|....|.:.....|...|.....| |||   .|.......||...:    .|
Human  1113 ---------QCHCRAGFGGRTCSECQELHWGDPGLQC-HAC---DCDSRGIDTPQCHRFTGHCSC 1164

  Fly   818 RCSIHNERCNKAAE----VPPEQLP-------------ELALH----KSKVLETKDNGEAAKKVS 861
            |..:...||::.|.    :.|...|             :||..    :.:..|.:..|......|
Human  1165 RPGVSGVRCDQCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVLGAFES 1229

  Fly   862 GLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATA------------------ 908
            ...|.:  :|...:.....|.:|:.::|:.....||.......|||.                  
Human  1230 SFWHMQ--EKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFN 1292

  Fly   909 --GALSNEEIEDDIIFRLVQQQQQQ--------------KELKKQHQQT-------TTTAPATST 950
              .|||..| .|.:...|..:|..|              ..::..|.|:       .|:|.|..:
Human  1293 ANHALSGLE-RDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPS 1356

  Fly   951 TSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTS 1015
            ..|..:.|:.|......|.|.:.:.| :.|..|.|.:|..|         :..|:..|.|:.|..
Human  1357 PVSNSASARHRTEALMDAQKEDFNSK-HMANQRALGKLSAH---------THTLSLTDINELVCG 1411

  Fly  1016 LQQQEYGDAMAASQ----VPLAFEDASP--------GTPRSSD--------NNEDDENAFVFDES 1060
            ..    |||..|:.    .....||..|        |...::|        ...:.:.|.....|
Human  1412 AP----GDAPCATSPCGGAGCRDEDGQPRCGGLSCNGAAATADLALGRARHTQAELQRALAEGGS 1472

  Fly  1061 LFD-----ASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSD 1120
            :..     ....:|..||.|.|.|        .|::|..:.|     |.:||:    ::..|...
Human  1473 ILSRVAETRRQASEAQQRAQAALD--------KANASRGQVE-----QANQEL----QELIQSVK 1520

  Fly  1121 DYNDDELLTP 1130
            |:.:.|...|
Human  1521 DFLNQEGADP 1530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_611082.2 FXa_inhibition 53..82 CDD:464251
LamG 404..555 CDD:238058 20/157 (13%)
EGF 583..612 CDD:394967 11/56 (20%)
LamG 625..774 CDD:238058 29/190 (15%)
LamG 1205..1340 CDD:214598
LAMB2NP_002283.3 Laminin_N 47..281 CDD:459653
EGF_Lam 283..335 CDD:238012
Laminin_EGF 347..398 CDD:395007
Laminin_EGF 410..467 CDD:395007
EGF_Lam 469..520 CDD:238012
EGF_Lam 521..562 CDD:238012
Laminin_EGF 783..831 CDD:395007 15/74 (20%)
Laminin_EGF 831..879 CDD:395007 14/123 (11%)
EGF_Lam 876..921 CDD:238012 12/51 (24%)
EGF_Lam 926..984 CDD:238012 11/64 (17%)
Laminin_EGF 986..>1028 CDD:395007 7/41 (17%)
EGF_Lam 1037..1093 CDD:238012 12/73 (16%)
Laminin_EGF 1095..1143 CDD:395007 10/67 (15%)
Laminin_EGF 1143..1190 CDD:395007 10/49 (20%)
Domain II 1190..1409 42/231 (18%)
SMC_prok_B <1244..1593 CDD:274008 63/319 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1338..1364 5/25 (20%)
Domain alpha 1410..1442 7/35 (20%)
Domain I 1443..1798 20/105 (19%)
Smc <1449..>1786 CDD:440809 19/99 (19%)
cc_LAMB2_C 1727..1798 CDD:411970
Blue background indicates that the domain is not in the aligned region.

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