Protein Alignment SP2353 and eys

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_001027571.3
• Gene: eys / 3771890
• FlyBaseID: FBgn0031414
• Length: 2176
• Species: Drosophila melanogaster
• Alignment Length: 1347
• Identity: 277/1347 - (20%)
• Similarity: 448/1347 - (33%)
• Gaps: 370/1347 - (27%)

  Fly   221 TMLPSSVPPTPSRSTTRATASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVY 285
            |..|.::||||..:.:..|....|:......:|...|
  Fly   944 TQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPP---------------------------- 980

  Fly   286 DDVNNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAVVG 350
                             |..||.           |:||.:      :.|......:|.......|
  Fly   981 -----------------TASQTK-----------PSVTES------SEEVEGTNTVSTGGRGSGG 1011

  Fly   351 AAMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPA 415
            .............|.|.:.|.|.  .|:..|||:|.|.:.|..|:..|......|:..|:::
  Fly  1012 VPEEKAGDVDCIKLGCYNGGTCV--TTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVS--- 1071

  Fly   416 LHGAYK--------------HVQLRIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFD 466
             |..||              |:||::  |..:.:|:|:|:..:....|.:|||.|.||.::|.|.
  Fly  1072 -HRIYKDIGGHESLDAVLPMHIQLKV--RTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFS 1133

  Fly   467 CGSGVGSVRSRETILLNEWNSVIIYRH---------------RWDAWLVLNHGTKVQGRS----N 512
            ||        .:|:||:|..:.:...|               ..:|.|::|....:.|..    .
  Fly  1134 CG--------LQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLK 1190

  Fly   513 GLFSRITFREPVF-----LGGIGNI-TGLAKRLPLAE---GFAGCIRRFVANEHDYKFTEHPLGD 568
            .|..|:...|.:.     |||.... .||...||.|:   ||.||:.....|..    .....||
  Fly  1191 LLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQ----AREIFGD 1251

  Fly   569 VINGFDIQDCSTDKCVRYPCQHGGKCLPSD----------------------------------- 598
            .::||.|.:|.:..|:..||::|..|:..:
  Fly  1252 ALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDN 1316

  Fly   599 -------------QGAICLCPIGFVGDLCEIRMDLQVPAFNG-----SSFLRYA---PLGDSALI 642
                         .|.:||||:|..|..||..:::.:|:|:|     |||:.|.   ||..|
  Fly  1317 PCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYS--- 1378

  Fly   643 WLELKVTLKPEQAD--GLILYSGP----EHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSL 701
             |||...:.|:...  .|:.:.|.    :.:.|.:|:....|::...::||:||..:.::..:..
  Fly  1379 -LELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDF 1442

  Fly   702 -----GQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGG--VNHVDRLPLDLK 759
                 ...:.||:.|..|.|.|.||....:...|......:.:...|::||  :.:.:.||.||.
  Fly  1443 RLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLP 1507

  Fly   760 YKPFFVGCIQRIDINGHSLGI-VAEALG--GSNIGNC------PHAC------------------ 797
            ....|.|||..:.:....:.: :.|..|  |..:|.|      .|||
  Fly  1508 LHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQ 1572

  Fly   798 -------VARPCGPL----------AECVPQMESYECRCSIHNERCNKAAEVPPEQLPELAL-HK 844
                   .|:|..|.          |.|||.:..|||.|.:  .|..|..|.....|.:::| .:
  Fly  1573 EGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPV--GRTGKNCEEVIRSLSDVSLTGR 1635

  Fly   845 SKVLETK-----DNGE--AAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSER 902
            ...|..:     |.|:  .||:...::::..:||   |..|.|.|:.::..........|.....
  Fly  1636 RSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKK---LMPPKPITTPSSHFVMKLLNEVEKQRSF 1697

  Fly   903 TEEATAGALSNEE--------IEDD----------IIFRLVQQQQQQK----ELKKQHQQTTTTA 945
            :.....|:.|.||        ||..          :.|..:...|.:|    .|..|       .
  Fly  1698 SPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQ-------G 1755

  Fly   946 PATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNN 1010
            .......||||.....:......:..|.|....|...|.|:.......|....|.:::|...|:.
  Fly  1756 GVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSL 1820

  Fly  1011 DWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQ 1075
            .::..|:........|.|..|:.|.....|...|......:|...|...::.|. |||
  Fly  1821 LYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDC-DGT------- 1877

  Fly  1076 LAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDD------YNDDELL------ 1128
             |.......|..:.....|.......|:      .|..|..:||:.      .|:...|
  Fly  1878 -ACGGDSCESGGHCWLDEKLQPHCICPE------YAKGDRCEYSETCKLIPCKNNGRCLRSGRCS 1935

  Fly  1129 TPVMQGGEEVKLEQHTSSTPQTHTDWSLL---KKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHY 1190
            .|...||...::.....:||....:..|:   .:..:..:.:               |...|...
  Fly  1936 CPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRR---------------GPSLYVRP 1985

  Fly  1191 NDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYD-LGSGE 1254
            .:|          |.::|...|...:|::||     :..|...:|.||:|.|:|....: |||..
  Fly  1986 REA----------IQVSLNFSTIEPDGLLLW-----SEHERSKFLGLGLEAGHLKLASNLLGSTN 2035

  Fly  1255 VDIRFNGTK-VSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTG----------- 1307
            ..:|...:. ::||.||....:.:.....|::||....|.|.|...|.|.:.|.
  Fly  2036 DTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNS 2100

  Fly  1308 -----------LYVGGMPD---VGYFTHQRYFSGIVGCISEIVLAGE 1340
                       .|:||.|:   |...|..|:|....||:.:|....|
  Fly  2101 SKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAE 2147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251
		LamG	404..555	CDD:238058	47/192 (24%)
		EGF	583..612	CDD:394967	11/76 (14%)
		LamG	625..774	CDD:238058	42/169 (25%)
		LamG	1205..1340	CDD:214598	40/161 (25%)
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011
		EGF_CA	220..256	CDD:238011
		EGF_CA	<270..298	CDD:238011
		EGF_CA	301..336	CDD:238011
		EGF	342..371	CDD:394967
		EGF_CA	378..413	CDD:238011
		Laminin_G_2	1096..1244	CDD:460494	40/157 (25%)
		EGF_CA	1314..1346	CDD:238011	7/31 (23%)
		LamG	1355..1521	CDD:238058	42/169 (25%)
		EGF	1549..1578	CDD:394967	3/28 (11%)
		EGF_CA	1585..1621	CDD:238011	11/37 (30%)
		Laminin_G_2	1723..1856	CDD:460494	25/139 (18%)
		LamG	1956..2144	CDD:238058	45/217 (21%)