DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and AGRN

DIOPT Version :10

Sequence 1:NP_611082.2 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:NP_001292204.1 Gene:AGRN / 375790 HGNCID:329 Length:2068 Species:Homo sapiens


Alignment Length:1414 Identity:289/1414 - (20%)
Similarity:428/1414 - (30%) Gaps:551/1414 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 LSSLSSASIAVGAIPEPEEAAFQ---GHC--GHT-------SPCEQLCYEIHDGMYECDCIEGYE 74
            |..|..:|:|....|....:.:.   |.|  |.|       |.|.  ..::..|:.|.:.:||.|
Human  1085 LEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCP--ATKVFQGVLELEGVEGQE 1147

  Fly    75 LNKNGYSCQVINATSNSLDGRGKSDE---DVLYQ----KGASFSAKLANDDGGKSMA-------K 125
            |   .|:.::.:..|.......:|.|   |.|::    |....|.:|.:...|||:.       .
Human  1148 L---FYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFD 1209

  Fly   126 STFALSAAQSASPAGNENGEDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNSN 190
            .|.|..|...|...                        ..:.|..:::||.:::..|:..:....
Human  1210 PTTAFRAPDVARAL------------------------LRQIQVSRRRSLGVRRPLQEHVRFMDF 1250

  Fly   191 DYYISAESINFNSESEGQEQQDVADFKAASTMLPSS--VPPTPSRSTTRATASTTTTTTTTRRSP 253
            |::.:.    ....:.|............::.||||  .|..|..|.|....:.||...||||.|
Human  1251 DWFPAF----ITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPP 1311

  Fly   254 TRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNTAKNRRK 318
            |.||.:                                                     ...|| 
Human  1312 TTAPSR-----------------------------------------------------VPGRR- 1322

  Fly   319 YPNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRC 383
                                      .||........| |.|     |...|.|...|......|
Human  1323 --------------------------PPAPQQPPKPCD-SQP-----CFHGGTCQDWALGGGFTC 1355

  Fly   384 LCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLT 448
            .||.|:.|..|::.:.|.||.|..||:||||.|. ||..::|.:|||.....|::|.:|   :..
Human  1356 SCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLR-AYHTLRLALEFRALEPQGLLLYNG---NAR 1416

  Fly   449 G-DFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSN 512
            | ||:||.|..|.|:..||.|||...:.|...:...:|:.:.:.||.....|.::..|.|.|.|.
Human  1417 GKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESP 1481

  Fly   513 GLFSRITFREPVFLGGI--GNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHPLGDVINGFDI 575
            .....:.....:|:||:  .......:|..:..|..||||....|....:....| |....|..:
Human  1482 SGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGP-GAATRGSGV 1545

  Fly   576 QDCSTDKCVRYPCQHGG-----------------------------KCLPS------------DQ 599
            .:|....|:..|| |||                             .|.|:            :.
Human  1546 GECGDHPCLPNPC-HGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEG 1609

  Fly   600 GAICLCPIGFVGDLCEIR--MDLQVP---AFNGSSFLRY-------APLGDSALIWLELKVTLKP 652
            ||.|.||:|..|..|:..  .|...|   .|||.|.|..       ..||:.    :.|:|....
Human  1610 GAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEK----MALEVVFLA 1670

  Fly   653 EQADGLILYSG--PEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARL 715
            ....||:||:|  .:.:|||::|.|.|..:||.:|||.|.|::||...::||.|..:.:.|..|.
Human  1671 RGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRK 1735

  Fly   716 AVLKVDKHQEVLTIS--SNGFWH--LSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGH 776
            ..|:|.....||..|  |....|  |:|.:.|:|||.....:|.........|.|.||.:.:.|.
Human  1736 GALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGR 1800

  Fly   777 SLGIVAEALGGSNIGN-CPHACV---ARPCGPLAECVPQMESYECRC--SIHNERCNKAAEVPPE 835
            .|......|...::.: ..|.|.   ..||...|.|||:..:|.|.|  ......|.|       
Human  1801 QLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEK------- 1858

  Fly   836 QLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPS 900
                                      ||..|                                  
Human  1859 --------------------------GLVEK---------------------------------- 1863

  Fly   901 ERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGK 965
                                                               |:|           
Human  1864 ---------------------------------------------------SAG----------- 1866

  Fly   966 HHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAASQV 1030
                                              |.|.|.| |...:|      ||.:|:..|::
Human  1867 ----------------------------------DVDTLAF-DGRTFV------EYLNAVTESEL 1890

  Fly  1031 PLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKK 1095
                                                                             
Human  1891 ----------------------------------------------------------------- 1890

  Fly  1096 AEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLKKF 1160
                           |||               .||                |:|....:|..:.
Human  1891 ---------------ANE---------------IPV----------------PETLDSGALHSEK 1909

  Fly  1161 DLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQ 1225
            .|.:.|                                       ..|.::|.:..|::||:|: 
Human  1910 ALQSNH---------------------------------------FELSLRTEATQGLVLWSGK- 1934

  Fly  1226 GTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKT 1290
              ..|..||::|.|..|:|...|:|||..|.:| :...|:...|.||.|.|..:||.|:|.....
Human  1935 --ATERADYVALAIVDGHLQLSYNLGSQPVVLR-STVPVNTNRWLRVVAHREQREGSLQVGNEAP 1996

  Fly  1291 VTLRAPGKLRQLNTDTGLYVGGMPD--VGYFTHQRYFSGIVGCISEIVL 1337
            ||..:|....||:||..|::||:|:  ||....:.|.:|.|||:.::|:
Human  1997 VTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVV 2045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_611082.2 FXa_inhibition 53..82 CDD:464251 8/28 (29%)
LamG 404..555 CDD:238058 48/153 (31%)
EGF 583..612 CDD:394967 14/69 (20%)
LamG 625..774 CDD:238058 52/161 (32%)
LamG 1205..1340 CDD:214598 48/135 (36%)
AGRNNP_001292204.1 NtA 31..146 CDD:460825
KAZAL 196..242 CDD:197624
KAZAL 272..317 CDD:197624
KAZAL_FS 349..389 CDD:412159
KAZAL_FS 421..461 CDD:238052
KAZAL 489..534 CDD:197624
KAZAL 554..599 CDD:197624
KAZAL 619..664 CDD:197624
KAZAL 704..750 CDD:197624
Laminin_EGF 793..835 CDD:395007
Laminin_EGF 847..>883 CDD:395007
KAZAL 922..969 CDD:197624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 995..1096 4/10 (40%)
SEA 1130..1254 CDD:214554 27/150 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1334 22/136 (16%)
EGF 1333..1363 CDD:394967 11/35 (31%)
Laminin_G_1 1400..1531 CDD:395008 37/133 (28%)
EGF_CA 1555..1585 CDD:238011 5/30 (17%)
Laminin_G_1 1668..1803 CDD:395008 44/134 (33%)
EGF_CA 1825..1857 CDD:238011 9/31 (29%)
Laminin_G_1 1921..2051 CDD:395008 47/129 (36%)
Blue background indicates that the domain is not in the aligned region.

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