DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP2353 and agr-1

DIOPT Version :9

Sequence 1:	NP_001286474.1	Gene:	SP2353 / 36771	FlyBaseID:	FBgn0034070	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_001022152.3	Gene:	agr-1 / 3565243	WormBaseID:	WBGene00018304	Length:	1473	Species:	Caenorhabditis elegans

Alignment Length:	664	Identity:	130/664 - (19%)
Similarity:	237/664 - (35%)	Gaps:	168/664 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 QKQKSLNLQQQQQQQQKVNSNDYYISAESIN----------FNSESEG----QEQQDVADFKAAS 220
            :|:||    .|.:....:|| |:|.|.:.||          ...:.||    ...:|..|.:.:.
Worm   919 KKRKS----DQLELTTDINS-DWYFSRKDINRFSKLSMHIHLKEKREGILIRMVTEDKKDLQISH 978

  Fly   221 TMLPSSVPPTPSRSTTRATASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVY 285
                                       ..||...:..|.||       |.....:|:...::.
Worm   979 ---------------------------ENRRIVIKVGKARV-------DSLQTIAYNVSLELK-- 1007

  Fly   286 DDVNNNQLNLRRNSKSQTYQQTSNTNTAKNR------RKYPNVTSNKVQMHITRETNRLENISAA 344
              ...|:::.:.|.:.|.|......:::..|      .|:|.              |||.:|
Worm  1008 --WKRNEVHFKLNGEVQKYTFEDVLDSSVKRIYVGTDGKWPR--------------NRLNSI--- 1053

  Fly   345 EPAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRS 409
                ||.....|.....       |.|.........||.|                   :|.:..
Worm  1054 ----VGYLEIDDEPVRI-------DEIKPFYMAPEISRTL-------------------KFKENG 1088

  Fly   410 WLAFPALH-GAYKHVQLRIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGS 473
            ::.|..|. ...:..::.|.|:|...:||:.......|...||:|..:......|.::.|||:..
Worm  1089 FVQFENLQIDVRERTRVEIVFKPYRTNGILFYWSVPSDPHTDFIAFAMIDAKPHFVYELGSGLSY 1153

  Fly   474 VRSRETILLNEWNSVIIYRHRWDAWLVLNHG--TKVQGRSNGLFSRITFREPVFLGGI--GNITG 534
            :|. |.|.||.|::|.|.|...|..:.:|..  .|...:|......|:.::.:::|.:  |.|:.
Worm  1154 IRG-EPIPLNSWHTVRIERLAKDVSMFVNETLVKKHTSQSKNAHLDISKKDALYVGFVPEGIISH 1217

  Fly   535 LAKRLPLAEGFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDCS---TDKCVRYPCQHGGKCLP 596
            ..::|.:.  |.|.::....||...........:|::..|:.:.:   ..||       .|....
Worm  1218 KVRKLNVP--FEGELQELRINELPINLISGVSKEVMDKVDVMEINEKEISKC-------DGASFD 1273

  Fly   597 SDQGAICLCPIGFVGDLCEIRMDLQ------------VPAFNGSSF-LRYAPLGDSALIWLELKV 648
            .....:|.   ....|...|.::.|            |.:...|:| ..:..|....:||.|
Worm  1274 RKGSVVCR---QHENDARGIHINEQDALVFPNNVTFSVGSSKSSNFSFDFRTLKQFGVIWQE--- 1332

  Fly   649 TLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPAL--VRSEHSLSLGQWHTIKISR 711
                    |  .:|..:..|||:.:::.:|.:....:||:...|  :.:..:::...||::...|
Worm  1333 --------G--AWSQADEGGDFLLVFIEEGKLYVGVNLGADVHLKPISTNVTVADNHWHSVSFRR 1387

  Fly   712 TARLAVLKVDKHQEVLTISSNGFWHLSLDQN--LFVGGVN---HVDRLPLDLKYKPFFVGCIQRI 771
            ..|...|.||..:.:..::|.|  .::||.|  :::||.|   |.....|:|..|  ||||::.:
Worm  1388 KERKCELWVDSKKILHVVASPG--DVNLDSNGLVYLGGANPKKHKLLKSLNLSNK--FVGCVKNL 1448

  Fly   772 DINGHSLGIVAEAL 785
            .|.|..:.::.::|
Worm  1449 KIFGAEVNLLVDSL 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_001286474.1	FXa_inhibition	53..82	CDD:291342
		LamG	404..555	CDD:238058	36/155 (23%)
		EGF	583..612	CDD:278437	3/28 (11%)
		LamG	625..774	CDD:238058	38/156 (24%)
		LamG	1205..1340	CDD:214598
agr-1	NP_001022152.3	KAZAL	172..220	CDD:197624
		KAZAL	251..301	CDD:197624
		KAZAL	327..371	CDD:197624
		KAZAL	400..445	CDD:197624
		KAZAL	472..516	CDD:197624
		KAZAL	547..592	CDD:197624
		KAZAL	612..660	CDD:197624
		EGF_Lam	670..716	CDD:238012
		EGF_Lam	722..>759	CDD:238012
		KAZAL	<819..852	CDD:197624
		LamG	1081..1236	CDD:238058	37/176 (21%)
		LamG	1289..1450	CDD:238058	41/177 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17288at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920