Protein Alignment SP2353 and Lama2

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_063120697.1
• Gene: Lama2 / 309368
• RGDID: 1308889
• Length: 3225
• Species: Rattus norvegicus
• Alignment Length: 1492
• Identity: 278/1492 - (18%)
• Similarity: 477/1492 - (31%)
• Gaps: 529/1492 - (35%)

  Fly    90 NSLDGRGKSD----EDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASPAGNEN------- 143
            |.|.|..::.    |..|.:|.|.:..||  ||....:.::|.....|...|.|..:|
  Rat  1860 NKLFGEPRAQNEEMEKDLREKLAEYQNKL--DDAWDLLREATKKTKDADRLSAANQKNMTILETK 1922

  Fly   144 GEDESGS---------EGDS---------------YDY------------GELEDSNSE-TQEQK 171
            .|...||         ||:.               .||            .||.|...: .||.|
  Rat  1923 KEAIEGSKRQIENTLKEGNDILDEANRLAGEITSVIDYVEDIKTKLPPMSEELSDKIDDLAQEIK 1987

  Fly   172 QKSLNLQQQQQQQQKVNSND-------YYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPP 229
            .:.|..:..|.:......||       ....|::|:||:.:..:...::.|:...:..:......
  Rat  1988 DRRLAEKVFQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFRAYSNIKDYIDEAEKVAREAKE 2052

  Fly   230 TPSRSTTRATASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSD-MSVYDDVNNNQL 293
            ....:|..||            ||....|:       :..||...|:...:: ..:.:||..|..
  Rat  2053 LAHEATKLAT------------SPQGLLKE-------DAKGSLQKSFRILNEAKKLANDVKENHN 2098

  Fly   294 NLRRNSKSQTYQQTSN----------TNTAKNRRKYPNVTSNKVQ-------------------- 328
            :|   |..:|..:|::          .:|.......||.|:.|:|
  Rat  2099 DL---SGLKTRLETADLRNSGLLGALNDTMDKLSAIPNDTAAKLQAVKEKAREANDTAKAVLAQV 2160

  Fly   329 --MH-----ITRETNRLENISAAEPAVV--GAAMTTDRSTPTCNLDCGSDGIC------------ 372
              :|     :.:..|:|.:..|...|||  .:....|......||:..:|.:.
  Rat  2161 KDLHQNLDGLKQNYNKLADSVAKTNAVVKDPSKNIADAGATVRNLEQEADRLIDKLKPIKELEDN 2225

  Fly   373 ----------ALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRI 427
                      .:......:..:.....:|..|   ||.:.|...|          |:|.::.:.:
  Rat  2226 LKKNISEIKELINQARKQANSIKVSVSSGGDC---IRTYKPEIKK----------GSYNNIVVHV 2277

  Fly   428 EFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVII-- 490
              :....|.::...|....:  ||:|:.:.||.|.|.:|.|||||.|         |:..:.|
  Rat  2278 --KTAVADNLLFYLGSAKFI--DFLAIEMRKGKVSFLWDVGSGVGRV---------EYPDLTIDD 2329

  Fly   491 -YRHRWDAWLVLNHGTKVQGRSNGLFSR--------------------------ITFREPVFLGG 528
             |.:|.:|        ...||:..:..|                          :.....:|:||
  Rat  2330 SYWYRIEA--------SRTGRNGSISVRALDGPKASMVPSTHHSVSPPGYTILDVDANAMLFVGG 2386

  Fly   529 IGNITGLAKRLPLAE--GFAGCIRRFVANEHDYKFTEHPLGDVINGF-----DIQDCSTDKCVRY 586
               :||..|:.....  .|.||:       .:..|...|:|  :..|     |.:.|:....|.
  Rat  2387 ---LTGKIKKADAVRVTTFTGCM-------GETYFDNKPIG--LWNFREKEGDCKGCTVSPQVE- 2438

  Fly   587 PCQHGGKCLPSDQGAICLCPIGFVGDLCEIRMDLQVPAFNGSSF------LRYAPLGDSALIWLE 645
                      ..:|.|                     .|:|..:      :|:.|...:.:.
  Rat  2439 ----------DSEGTI---------------------QFDGEGYALVSRPIRWYPNISTVMF--- 2469

  Fly   646 LKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKIS 710
               ..:...::.|::|.......||:::.|:||.|:.::|||||.|.|.|..:.:.|:|.:..:|
  Rat  2470 ---KFRTFSSNALLMYLATRDLKDFMSVELSDGHVKVSYDLGSGMASVVSNQNHNDGKWKSFTLS 2531

  Fly   711 R---TARLAVLKVDKHQE--VLTISSNGFWHLSL--DQNLFVGGVNHVDRLP----LDLKYKP-- 762
            |   .|.::::.:|.:||  :.|.||...:.|.|  |..::.||      ||    |.:|.:|
  Rat  2532 RIQKQANISIVDIDSNQEENIATSSSGNNFGLDLKADDKIYFGG------LPTLRNLSMKARPEV 2590

  Fly   763 ---FFVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESYECRCSIHNE 824
               .:.||::.|:|:.....|::.                          |........||:.|.
  Rat  2591 NVKKYSGCLKDIEISRTPYNILSS--------------------------PNYVGVTKGCSLENV 2629

  Fly   825 RCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTT 889
               .....|.....|||                                       |.|....|.
  Rat  2630 ---YTVSFPKPGFVELA---------------------------------------AVSIDVGTE 2652

  Fly   890 STTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTT---------- 944
            ...:.:|...|......:.|.|:..                    :::.:|||..
  Rat  2653 INLSFSTRNESGIILLGSGGTLTPP--------------------RRKRRQTTQAYYAIFLNKGR 2697

  Fly   945 -----APATSTTSSGPSKAKPRLSGKHHASKHEHHL-KPNAAFTRKLSRLPTHYES--------- 994
                 :..|.|......|.:|.|.  |...:|..|: :....||.::.....|.::
  Rat  2698 LEVHLSSGTRTMRKIVIKPEPNLF--HDGREHSVHVERTRGVFTVQVDENRRHMQNLTEEQPIEV 2760

  Fly   995 -----------FQTNPDSDILTFEDN--NDWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSD 1046
                       ||.:|..:|..|:..  |..:.|:       .|..:| |:||::|..|......
  Rat  2761 KKLFVGGAPPEFQPSPLRNIPAFQGCVWNLVINSI-------PMDFAQ-PIAFKNADIGRCAYQK 2817

  Fly  1047 NNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTA 1111
            ..|::::|.                                       .|||...||
  Rat  2818 PREEEDDAV---------------------------------------PAEVTVQPQ-------- 2835

  Fly  1112 NEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKN 1176
                              ||              .||........:......||.:.......|.
  Rat  2836 ------------------PV--------------PTPAFPFPAPTMVHGPCVAESEPAFLSGSKQ 2868

  Fly  1177 FGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQ 1241
            ||   ...:|:......||.   :...:.:.|.::|.:|:|::.:..|    ..|.|:.::.:..
  Rat  2869 FG---LSRNSHIALAFDDTK---VKNRLTIELEVRTEAESGLLFYMAR----INHADFATVQLRN 2923

  Fly  1242 GYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDT 1306
            |:.:|.||||||:..... .|:::||.||:::..|..|||.|.||.....|: :|.|...|:...
  Rat  2924 GFPYFSYDLGSGDTSTMI-PTRINDGQWHKIKITRVKQEGILSVDDASNQTI-SPKKADILDVVG 2986

  Fly  1307 GLYVGGMPDVGYFTHQ----RYFSGIVGCISEIVLAGEMKLNFDPNT----LGT-EHNVETG 1359
            .|||||:| :.|.|.:    .|  .:.||:..:.:. :..::.|..|    :|| ..|.|.|
  Rat  2987 ILYVGGLP-INYTTRRIGPVTY--SLDGCVRNLYME-QAPVDLDQPTSSFHVGTCFANAEKG 3044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251
		LamG	404..555	CDD:238058	36/181 (20%)
		EGF	583..612	CDD:394967	3/28 (11%)
		LamG	625..774	CDD:238058	44/170 (26%)
		LamG	1205..1340	CDD:214598	42/138 (30%)
Lama2	XP_063120697.1	None